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    PDGFB platelet derived growth factor subunit B [ Oryctolagus cuniculus (rabbit) ]

    Gene ID: 100358772, updated on 8-Mar-2024

    Summary

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    Gene symbol
    PDGFB
    Gene description
    platelet derived growth factor subunit B
    See related
    Ensembl:ENSOCUG00000038923
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Oryctolagus cuniculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
    Orthologs
    human mouse all
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    Genomic context

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    See PDGFB in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_02 current UM_NZW_1.0 (GCF_009806435.1) 4 NC_067377.1 (91740161..91755847)

    Chromosome 4 - NC_067377.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA U83B Neighboring gene small nucleolar RNA U83B Neighboring gene ribosomal protein L3 Neighboring gene chromobox 7 Neighboring gene DNA dC->dU-editing enzyme APOBEC-3H Neighboring gene uncharacterized LOC103348386

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_067377.1 Chromosome 4 Reference UM_NZW_1.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Platelet-derived growth factor-β expression in rabbit models of cerebral vasospasm following subarachnoid hemorrhage. Cui HK, et al. Mol Med Rep, 2014 Sep. PMID 24969827
    2. Expression of platelet-derived growth factor-B mRNA during vaginal vs. dermal incisional wound healing in the rabbit. Abramov Y, et al. Eur J Obstet Gynecol Reprod Biol, 2012 Jun. PMID 22464204
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PDGF-beta was expressed as early as 3 h post-Subarachnoid hemorrhage. It was evident after 1 day and reached a peak in 7 days, suggesting that PDGF-beta is involved in the early stages of cerebral vasospasm.
      Title: Platelet-derived growth factor-β expression in rabbit models of cerebral vasospasm following subarachnoid hemorrhage.
    2. PDGF-B mRNA expression significantly correlates with incisional vaginal and cutaneous wound closure.
      Title: Expression of platelet-derived growth factor-B mRNA during vaginal vs. dermal incisional wound healing in the rabbit.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables platelet-derived growth factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in platelet-derived growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of MAP kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of protein autophosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    platelet-derived growth factor subunit B
    Names
    platelet-derived growth factor beta polypeptide

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_009806435.1-RS_2023_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference UM_NZW_1.0 Primary Assembly

    Genomic

    1. NC_067377.1 Reference UM_NZW_1.0 Primary Assembly

      Range
      91740161..91755847
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_051845885.1 → XP_051701845.1  platelet-derived growth factor subunit B isoform X1

    2. XM_051845886.1 → XP_051701846.1  platelet-derived growth factor subunit B isoform X2

    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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