CXCL8 C-X-C motif chemokine ligand 8 [Oryctolagus cuniculus (rabbit)] - Gene

Summary

Gene symbol: CXCL8
Gene description: C-X-C motif chemokine ligand 8
See related: Ensembl:ENSOCUG00000011835
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Oryctolagus cuniculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
Also known as: IL8
Orthologs: human all
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Genomic context

Location:: chromosome: 15

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2023_02	current	UM_NZW_1.0 (GCF_009806435.1)	15	NC_067388.1 (73265161..73267893, complement)

Chromosome 15 - NC_067388.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_067388.1 Chromosome 15 Reference UM_NZW_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

At the 2-wk time point, interleukin 8 gene expression was comparable in intervertebral discs injected with chondrocytes in controls, whereas its expression in IVDs injected with saline increased 50-fold
Title: Allogeneic Articular Chondrocyte Transplantation Downregulates Interleukin 8 Gene Expression in the Degenerating Rabbit Intervertebral Disk In Vivo.
Data show that the serum levels of mast cell tryptase, monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8) decreased significantly in Dachengqi decoction treatment group.
Title: [Dachengqi decoction reduces the serum levels of mast cell tryptase and inflammatory cytokines in rabbits with post-cardiac arrest syndrome].
The JNK pathway plays an important role in mechanical ventilation-stimulated TNF-alpha expression in alveolar macrophages, but the injury-stimulated IL-8 expression may be regulated by other signaling pathways.
Title: Role of the JNK pathway on the expression of inflammatory factors in alveolar macrophages under mechanical ventilation.
IL-8 and IL-1ra showed correlation with the severity of colitis. These observations should significantly further understandings on the role of neutrophils and monocytes in the immunopathogenesis of ulcerative colitis
Title: Correlation of neutrophil and monocyte derived interleukin-1 receptor antagonist and interleukin-8 with colitis severity in the rabbit.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables CXCR chemokine receptor binding	IEA Inferred from Electronic Annotation more info	PubMed
enables chemokine activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cellular response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info	PubMed
involved_in chemokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in neutrophil chemotaxis	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: interleukin-8

Names: C-X-C motif chemokine 8; IL-8; NAP-1; PF1; RPF1; chemokine (C-X-C motif) ligand 8; neutrophil attractant/activation protein-1; permeability factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001082293.1 → NP_001075762.1 interleukin-8 precursor

See identical proteins and their annotated locations for NP_001075762.1

Status: PROVISIONAL

Source sequence(s)

M57439

UniProtKB/Swiss-Prot

P19874

UniProtKB/TrEMBL

A0A0N7F226, A0A0N9HLR8, A0A0N9HPG6

Related

ENSOCUP00000018795.1, ENSOCUT00000030077.3

Conserved Domains (1) summary

cd00273
Location:31 → 94

Chemokine_CXC; Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members ...