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    POLY polyprotein [ Dengue virus 2 ]

    Gene ID: 1494449, updated on 5-Feb-2024

    Summary

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    Gene symbol
    POLY
    Gene description
    polyprotein
    Locus tag
    DENV_gp1
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Dengue virus 2 (strain: 16681)
    Lineage
    Viruses; Riboviria; Flaviviridae; Flavivirus
    Also known as
    polyprotein gene
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    Genomic context

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    Sequence:
    NC_001474.2 (97..10272)

    NC_001474.2Genomic Context describing neighboring genes

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001474.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dengue virus NS5 degrades ERC1 during infection to antagonize NF-kB activation. Gonzalez Lopez Ledesma MM, et al. Proc Natl Acad Sci U S A, 2023 Jun 6. PMID 37252973, Free PMC Article
    2. The Dengue virus protease NS2B3 cleaves cyclic GMP-AMP synthase to suppress cGAS activation. Bhattacharya M, et al. J Biol Chem, 2023 Mar. PMID 36754281, Free PMC Article
    3. Determinants in Nonstructural Protein 4A of Dengue Virus Required for RNA Replication and Replication Organelle Biogenesis. Cortese M, et al. J Virol, 2021 Oct 13. PMID 34379504, Free PMC Article
    4. Novel insights into the function of an N-terminal region of DENV2 NS4B for the optimal helicase activity of NS3. Lu H, et al. Virus Res, 2021 Apr 2. PMID 33485995
    5. Mutations in the cytoplasmic domain of dengue virus NS4A affect virus fitness and interactions with other non-structural proteins. Tan MJA, et al. J Gen Virol, 2020 Sep. PMID 32589122

    See all (280) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification of a critical role for ZIKV capsid alpha3 in virus assembly and its genetic interaction with M protein.
      Title: Identification of a critical role for ZIKV capsid α3 in virus assembly and its genetic interaction with M protein.
    2. DENV-2 NS1 promotes AMPK-LKB1 interaction to activate AMPK/ERK/mTOR signaling pathway to induce autophagy.
      Title: DENV-2 NS1 promotes AMPK-LKB1 interaction to activate AMPK/ERK/mTOR signaling pathway to induce autophagy.
    3. Dengue virus NS5 degrades ERC1 during infection to antagonize NF-kB activation.
      Title: Dengue virus NS5 degrades ERC1 during infection to antagonize NF-kB activation.
    4. The Dengue virus protease NS2B3 cleaves cyclic GMP-AMP synthase to suppress cGAS activation.
      Title: The Dengue virus protease NS2B3 cleaves cyclic GMP-AMP synthase to suppress cGAS activation.
    5. Novel insights into the function of an N-terminal region of DENV2 NS4B for the optimal helicase activity of NS3.
      Title: Novel insights into the function of an N-terminal region of DENV2 NS4B for the optimal helicase activity of NS3.
    6. Mapping of molecular interactions between human E3 ligase TRIM69 and Dengue virus NS3 protease using hydrogen-deuterium exchange mass spectrometry.
      Title: Mapping of molecular interactions between human E3 ligase TRIM69 and Dengue virus NS3 protease using hydrogen-deuterium exchange mass spectrometry.
    7. Dengue and Zika Virus Capsid Proteins Contain a Common PEX19-Binding Motif.
      Title: Dengue and Zika Virus Capsid Proteins Contain a Common PEX19-Binding Motif.
    8. Determinants in Nonstructural Protein 4A of Dengue Virus Required for RNA Replication and Replication Organelle Biogenesis.
      Title: Determinants in Nonstructural Protein 4A of Dengue Virus Required for RNA Replication and Replication Organelle Biogenesis.
    9. Dengue and Zika virus capsid proteins bind to membranes and self-assemble into liquid droplets with nucleic acids.
      Title: Dengue and Zika virus capsid proteins bind to membranes and self-assemble into liquid droplets with nucleic acids.
    10. Mutations in the cytoplasmic domain of dengue virus NS4A affect virus fitness and interactions with other non-structural proteins.
      Title: Mutations in the cytoplasmic domain of dengue virus NS4A affect virus fitness and interactions with other non-structural proteins.
    Submit: New GeneRIF Correction See all GeneRIFs (113)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    regulatory

    • Loc: 134-144 regulatory_class = other

    stem_loop

    • Loc: 116-132

    General protein information

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    Preferred Names
    polyprotein
    Names
    anchored capsid protein ancC
    capsid protein C
    membrane glycoprotein precursor prM
    membrane glycoprotein M
    envelope protein E
    nonstructural protein NS1
    nonstructural protein NS2A
    nonstructural protein NS2B
    nonstructural protein NS3
    nonstructural protein NS4A
    protein 2K
    nonstructural protein NS4B
    RNA-dependent RNA polymerase NS5
    protein pr
    NP_056776.2
    • contains structural proteins, C-prM/M-E and non-structural proteins, NS1-NS2A/B-NS3-NS4A/B-NS5

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001474.2 Reference assembly

      Range
      97..10272
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_056776.2 polyprotein [Dengue virus 2]

      See identical proteins and their annotated locations for NP_056776.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A173DS53, D0EPS0, O09234
      Conserved Domains (17) summary
      cd12149
      Location:585 → 674
      Flavi_E_C; Immunoglobulin-like domain III (C-terminal domain) of Flavivirus envelope glycoprotein E
      TIGR04240
      Location:679 → 775
      flavi_E_stem; flavivirus envelope glycoprotein E, stem/anchor domain
      smart00487
      Location:1657 → 1800
      DEXDc; DEAD-like helicases superfamily
      pfam01003
      Location:5 → 114
      Flavi_capsid; Flavivirus capsid protein C
      pfam00869
      Location:282 → 576
      Flavi_glycoprot; Flavivirus glycoprotein, central and dimerization domains
      pfam00948
      Location:777 → 1130
      Flavi_NS1; Flavivirus non-structural Protein NS1
      pfam00949
      Location:1494 → 1642
      Peptidase_S7; Peptidase S7, Flavivirus NS3 serine protease
      pfam00972
      Location:2742 → 3380
      Flavi_NS5; Flavivirus RNA-directed RNA polymerase
      pfam01002
      Location:1349 → 1475
      Flavi_NS2B; Flavivirus non-structural protein NS2B
      pfam01004
      Location:207 → 280
      Flavi_M; Flavivirus envelope glycoprotein M
      pfam01005
      Location:1138 → 1342
      Flavi_NS2A; Flavivirus non-structural protein NS2A
      pfam01349
      Location:2244 → 2484
      Flavi_NS4B; Flavivirus non-structural protein NS4B
      pfam01350
      Location:2098 → 2240
      Flavi_NS4A; Flavivirus non-structural protein NS4A
      pfam01570
      Location:126 → 204
      Flavi_propep; Flavivirus polyprotein propeptide
      pfam01728
      Location:2546 → 2713
      FtsJ; FtsJ-like methyltransferase
      pfam07652
      Location:1660 → 1805
      Flavi_DEAD; Flavivirus DEAD domain
      cl21455
      Location:1830 → 1939
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NP_739581.2 anchored capsid protein ancC

      UniProtKB/TrEMBL
      A0A0K0WW33, I4AY88
      Conserved Domains (1) summary
      pfam01003
      Location:5 → 114
      Flavi_capsid; Flavivirus capsid protein C

    3. NP_739591.2 capsid protein C

      UniProtKB/TrEMBL
      A0A0K0WW33, W0GCK5
      Conserved Domains (1) summary
      pfam01003
      Location:5 → 100
      Flavi_capsid; Flavivirus capsid protein C

    4. NP_739582.2 membrane glycoprotein precursor prM

      UniProtKB/TrEMBL
      Q66346
      Conserved Domains (2) summary
      pfam01004
      Location:93 → 166
      Flavi_M; Flavivirus envelope glycoprotein M
      pfam01570
      Location:12 → 90
      Flavi_propep; Flavivirus polyprotein propeptide

    5. NP_739592.2 membrane glycoprotein M

      Conserved Domains (1) summary
      cl03065
      Location:2 → 75
      Flavi_M; Flavivirus envelope glycoprotein M

    6. NP_739583.2 envelope protein E

      UniProtKB/TrEMBL
      A0A2H5CUH3, Q88631
      Conserved Domains (3) summary
      cd12149
      Location:305 → 394
      Flavi_E_C; Immunoglobulin-like domain III (C-terminal domain) of Flavivirus envelope glycoprotein E
      TIGR04240
      Location:399 → 495
      flavi_E_stem; flavivirus envelope glycoprotein E, stem/anchor domain
      pfam00869
      Location:2 → 296
      Flavi_glycoprot; Flavivirus glycoprotein, central and dimerization domains

    7. NP_739584.2 nonstructural protein NS1

      UniProtKB/TrEMBL
      H6UUY8, Q04040
      Conserved Domains (1) summary
      pfam00948
      Location:2 → 352
      Flavi_NS1; Flavivirus non-structural Protein NS1

    8. NP_739585.2 nonstructural protein NS2A

      UniProtKB/TrEMBL
      A0A3Q9SYF8, A0A3T0NKL3, A0A3T0NKP0
      Conserved Domains (1) summary
      pfam01005
      Location:11 → 215
      Flavi_NS2A; Flavivirus non-structural protein NS2A

    9. NP_739586.2 nonstructural protein NS2B

      UniProtKB/TrEMBL
      A0A1L2BPD3
      Conserved Domains (1) summary
      pfam01002
      Location:4 → 130
      Flavi_NS2B; Flavivirus non-structural protein NS2B

    10. NP_739587.2 nonstructural protein NS3

      Conserved Domains (4) summary
      smart00487
      Location:182 → 325
      DEXDc; DEAD-like helicases superfamily
      pfam00949
      Location:19 → 167
      Peptidase_S7; Peptidase S7, Flavivirus NS3 serine protease
      pfam07652
      Location:185 → 330
      Flavi_DEAD; Flavivirus DEAD domain
      cl21455
      Location:355 → 464
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    11. NP_739588.2 nonstructural protein NS4A

      UniProtKB/TrEMBL
      V5TI10
      Conserved Domains (1) summary
      pfam01350
      Location:5 → 127
      Flavi_NS4A; Flavivirus non-structural protein NS4A

    12. NP_739593.2 protein 2K

    13. NP_739589.2 nonstructural protein NS4B

      UniProtKB/TrEMBL
      V5THH8
      Conserved Domains (1) summary
      pfam01349
      Location:1 → 241
      Flavi_NS4B; Flavivirus non-structural protein NS4B

    14. NP_739590.2 RNA-dependent RNA polymerase NS5

      Conserved Domains (2) summary
      pfam00972
      Location:251 → 889
      Flavi_NS5; Flavivirus RNA-directed RNA polymerase
      pfam01728
      Location:55 → 222
      FtsJ; FtsJ-like methyltransferase

    15. YP_009164954.1 protein pr

      Conserved Domains (1) summary
      pfam01570
      Location:12 → 90
      Flavi_propep; Flavivirus polyprotein propeptide
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    AAB58782.1

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