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    L RNA-dependent RNA polymerase [ Zaire ebolavirus ]

    Gene ID: 911824, updated on 18-Aug-2023

    Summary

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    Gene symbol
    L
    Gene description
    RNA-dependent RNA polymerase
    Locus tag
    ZEBOVgp7
    Gene type
    protein coding
    RNA name
    polymerase
    RefSeq status
    PROVISIONAL
    Organism
    Zaire ebolavirus (isolate: Ebola virus/H.sapiens-tc/COD/1976/Yambuku-Mayinga)
    Lineage
    Viruses; ssRNA viruses; ssRNA negative-strand viruses; Mononegavirales; Filoviridae; Ebolavirus
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    Genomic context

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    Sequence:
    NC_002549.1 (11501..18282)

    NC_002549.1Genomic Context describing neighboring genes Neighboring gene polymerase complex protein Neighboring gene matrix protein Neighboring gene second secreted glycoprotein;small secreted glycoprotein;spike glycoprotein Neighboring gene minor nucleoprotein Neighboring gene membrane-associated protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002549.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ebola virus inhibits induction of genes by double-stranded RNA in endothelial cells. Harcourt BH, et al. Virology, 1998 Dec 5. PMID 9875327
    2. The complete nucleotide sequence of the Popp (1967) strain of Marburg virus: a comparison with the Musoke (1980) strain. Bukreyev AA, et al. Arch Virol, 1995. PMID 7487490
    3. Remdesivir targets a structurally analogous region of the Ebola virus and SARS-CoV-2 polymerases. Lo MK, et al. Proc Natl Acad Sci U S A, 2020 Oct 27. PMID 33028676, Free PMC Article
    4. DNA topoisomerase 1 facilitates the transcription and replication of the Ebola virus genome. Takahashi K, et al. J Virol, 2013 Aug. PMID 23658456, Free PMC Article
    5. The L-VP35 and L-L interaction domains reside in the amino terminus of the Ebola virus L protein and are potential targets for antivirals. Trunschke M, et al. Virology, 2013 Jul 5. PMID 23582637, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Remdesivir targets a structurally analogous region of the Ebola virus and SARS-CoV-2 polymerases.
      Title: Remdesivir targets a structurally analogous region of the Ebola virus and SARS-CoV-2 polymerases.
    2. Authors found that the phosphodiester bridge-cleaving and recombination activities of TOP1 are required for the polymerase activity of Ebola virus L protein.
      Title: DNA topoisomerase 1 facilitates the transcription and replication of the Ebola virus genome.
    3. A core binding domain spanning amino acids 280-370 of L was sufficient to mediate weak interaction with VP35, while the entire N-terminus up to amino acid 380 was required for strong VP35-L binding.
      Title: The L-VP35 and L-L interaction domains reside in the amino terminus of the Ebola virus L protein and are potential targets for antivirals.
    Submit: New GeneRIF Correction

    General gene information

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    regulatory

    • Loc: 11501-11512 regulatory_class = other
    • Loc: 11508-11518 regulatory_class = polyA_signal_sequence
    • Loc: 18272-18282 regulatory_class = polyA_signal_sequence

    General protein information

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    Preferred Names
    RNA-dependent RNA polymerase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002549.1 Reference assembly

      Range
      11501..18282
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_066251.1 RNA-dependent RNA polymerase [Zaire ebolavirus]

      See identical proteins and their annotated locations for NP_066251.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O39794, Q05318, Q773N0, Q8JS59, Q9DQD1
      UniProtKB/TrEMBL
      A0A0E3KN53, A0A0U3A3F9, A9QPM4, L7QHR8
      Conserved Domains (3) summary
      TIGR04198
      Location:1215 → 2204
      paramyx_RNAcap; mRNA capping enzyme, paramyxovirus family
      pfam00946
      Location:10 → 1089
      Mononeg_RNA_pol; Mononegavirales RNA dependent RNA polymerase
      pfam14318
      Location:1105 → 1357
      Mononeg_mRNAcap; Mononegavirales mRNA-capping region V
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    AAD14589.1

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