G attachment glycoprotein [Henipavirus nipahense] - Gene

Summary

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Gene symbol: G
Gene description: attachment glycoprotein
Locus tag: Nvgp5
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Henipavirus nipahense
Lineage: Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina; Monjiviricetes; Mononegavirales; Paramyxoviridae; Orthoparamyxovirinae; Henipavirus
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Genomic context

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Sequence:: NC_002728.1 (8710..11255)

NC_002728.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_002728.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

G and the fusion protein F are both crucial glycoproteins located on the surface of the virus envelope. [review]
Title: [Research Progress in Enveloped Glycoproteins and the Membrane-fusion Mechanism of Nipah Virus].
the binding of the viral attachment protein G to its host receptor ephrinB2 was studied and showed monomeric and dimeric receptors activate distinct conformational changes in G.
Title: Monomeric ephrinB2 binding induces allosteric changes in Nipah virus G that precede its full activation.
Using both coimmunoprecipitation and flow-cytometric strategies, we found a bidentate interaction between Nipah virus (NiV) G and F, where both the stalk and head regions of NiV G interact with F. This is a new structural-biological finding for the paramyxoviruses. Additionally, our studies disclosed regions of the NiV G and F glycoproteins dispensable for the G and F interactions.
Title: Multiple Strategies Reveal a Bidentate Interaction between the Nipah Virus Attachment and Fusion Glycoproteins.
Data suggest that fusion of Nipah viruses with host cells is facilitated by two of viral membrane proteins, the G protein and the F protein; G head domain binds to human ephrins B2 and B3 altering conformational density of entire G head domain.
Title: Discerning intersecting fusion-activation pathways in the Nipah virus using machine learning.
Authors identified a G stalk C-terminal region (amino acids 159 to 163) that is important for multiple G functions, including G tetramerization, conformational integrity, G-F interactions, receptor-induced conformational changes in G, and F triggering.
Title: Nipah virus attachment glycoprotein stalk C-terminal region links receptor binding to fusion triggering.
These findings are consistent with a general mechanism of paramyxovirus fusion activation in which the stalk domain of the receptor binding protein is responsible for F activation.
Title: Identification of a region in the stalk domain of the nipah virus receptor binding protein that is critical for fusion activation.
These findings suggest that the G-F interaction is not mediated entirely by the stalk domain of G.
Title: Individual N-glycans added at intervals along the stalk of the Nipah virus G protein prevent fusion but do not block the interaction with the homologous F protein.
Cysteine cluster in the G protein is involved in stabilizing a unique microdomain critical for triggering fusion.
Title: Cysteines in the stalk of the nipah virus G glycoprotein are located in a distinct subdomain critical for fusion activation.
Results indicated that the G-H loop of ephrin-B2 was indeed critical for the interaction between ephrin-B2 and Nipah virus-G.
Title: Mutations in the G-H loop region of ephrin-B2 can enhance Nipah virus binding and infection.
The authors conclude that distribution of Nipah virus F and G glycoproteins is responsible for lateral virus spread in both, epithelial and endothelial cell monolayers.
Title: Nipah virus infection and glycoprotein targeting in endothelial cells.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

General protein information

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Preferred Names: attachment glycoprotein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_002728.1 Reference assembly

Range

8710..11255

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NP_112027.1 attachment glycoprotein [Henipavirus nipahense]

See identical proteins and their annotated locations for NP_112027.1

Status: PROVISIONAL

UniProtKB/Swiss-Prot

Q4KTA8, Q5K4D8, Q9IH62

UniProtKB/TrEMBL

A0A1L7B8G8, A0A857UX53

Conserved Domains (1) summary

cd15468
Location:188 → 601

HeV-G; Glycoprotein G, or hemagglutinin-neuraminidase of Hendravirus and Nipah virus