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    CAL K-box region and MADS-box transcription factor family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 839172, updated on 15-Oct-2023

    Summary

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    Gene symbol
    CAL
    Gene description
    K-box region and MADS-box transcription factor family protein
    Primary source
    Araport:AT1G26310
    Locus tag
    AT1G26310
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AGAMOUS-like 10; AGL10; CAL1; CAULIFLOWER; F28B23.25; F28B23_25; MADS3
    Summary
    Floral homeotic gene encoding a MADS domain protein homologous to AP1. Enhances the flower to shoot transformation in ap1 mutants.
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    Genomic context

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    Location:
    chromosome: 1
    Exon count:
    8
    Sequence:
    Chromosome: 1; NC_003070.9 (9099994..9103644, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Phosphatidylinositol 3- and 4-kinase family protein Neighboring gene BSD domain-containing protein Neighboring gene uncharacterized protein Neighboring gene Zinc-binding dehydrogenase family protein Neighboring gene DNA binding protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Redundant regulation of meristem identity and plant architecture by FRUITFULL, APETALA1 and CAULIFLOWER. Ferrándiz C, et al. Development, 2000 Feb. PMID 10648231
    2. Gains and Losses of Cis-regulatory Elements Led to Divergence of the Arabidopsis APETALA1 and CAULIFLOWER Duplicate Genes in the Time, Space, and Level of Expression and Regulation of One Paralog by the Other. Ye L, et al. Plant Physiol, 2016 Jun. PMID 27208240, Free PMC Article
    3. Unique and redundant functional domains of APETALA1 and CAULIFLOWER, two recently duplicated Arabidopsis thaliana floral MADS-box genes. Alvarez-Buylla ER, et al. J Exp Bot, 2006. PMID 16893974
    4. Molecular basis of the cauliflower phenotype in Arabidopsis. Kempin SA, et al. Science, 1995 Jan 27. PMID 7824951
    5. Transcription Factor Interplay between LEAFY and APETALA1/CAULIFLOWER during Floral Initiation. Goslin K, et al. Plant Physiol, 2017 Jun. PMID 28385730, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LFY and AP1/CAL act as part of an incoherent feed-forward loop, a network motif where two interconnected pathways or transcription factors act in opposite directions on a target gene, to control the establishment of a stable developmental program for the formation of flowers.
      Title: Transcription Factor Interplay between LEAFY and APETALA1/CAULIFLOWER during Floral Initiation.
    2. the differences between the Arabidopsis (Arabidopsis thaliana) APETALA1 (AP1) and CAULIFLOWER (CAL) duplicate genes in the time, space, and level of expression were determined by the presence or absence of functionally important transcription factor-binding sites (TFBSs) in regulatory regions.
      Title: Gains and Losses of Cis-regulatory Elements Led to Divergence of the Arabidopsis APETALA1 and CAULIFLOWER Duplicate Genes in the Time, Space, and Level of Expression and Regulation of One Paralog by the Other.
    3. Expression of the transcription factor CAL is activated by LFY and the meristem identity regulator LMI1.
      Title: The LEAFY target LMI1 is a meristem identity regulator and acts together with LEAFY to regulate expression of CAULIFLOWER.
    4. The unique and redundant functions of the APETALA1 and CAULIFLOWER genes have been mapped to the four protein domains that characterize type-II MADS-domain proteins.
      Title: Unique and redundant functional domains of APETALA1 and CAULIFLOWER, two recently duplicated Arabidopsis thaliana floral MADS-box genes.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_102395.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within floral meristem determinacy IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of flower development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    K-box region and MADS-box transcription factor family protein
    NP_564243.1
    • CAULIFLOWER (CAL); FUNCTIONS IN: DNA binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: positive regulation of flower development, floral meristem determinacy; LOCATED IN: nucleus; EXPRESSED IN: 12 plant structures; EXPRESSED DURING: 4 anthesis, F mature embryo stage, petal differentiation and expansion stage, E expanded cotyledon stage, D bilateral stage; CONTAINS InterPro DOMAIN/s: Transcription factor, MADS-box (InterPro:IPR002100), Transcription factor, K-box (InterPro:IPR002487); BEST Arabidopsis thaliana protein match is: K-box region and MADS-box transcription factor family protein (TAIR:AT1G69120.1); Has 8035 Blast hits to 8024 proteins in 979 species: Archae - 8; Bacteria - 30; Metazoa - 829; Fungi - 313; Plants - 6634; Viruses - 0; Other Eukaryotes - 221 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      9099994..9103644 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_102395.3 → NP_564243.1  K-box region and MADS-box transcription factor family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_564243.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C0SUX4, Q39081, Q9C675, Q9S779, Q9S780, Q9SBG8, Q9SBG9, Q9SBH0, Q9SBH1, Q9SBH2, Q9SBH3, Q9SBH4, Q9SBH5, Q9SBH6
      UniProtKB/TrEMBL
      A0A178W9U9, A0A5S9VWQ3, A0A654EI44
      Conserved Domains (2) summary
      cd00265
      Location:2 → 79
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
      pfam01486
      Location:85 → 175
      K-box; K-box region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q39081.3

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