bark bark beetle [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: barkprovided by FlyBase
Official Full Name: bark beetleprovided by FlyBase
Primary source: FLYBASE:FBgn0031571
Locus tag: Dmel_CG3921
See related: AllianceGenome:FB:FBgn0031571
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: aka; Aka; Bark; CG3921; Dmel\CG3921
Summary: Predicted to enable carbohydrate binding activity. Involved in cell-cell junction organization; open tracheal system development; and response to endoplasmic reticulum stress. Located in lateral plasma membrane; septate junction; and tricellular tight junction. Is expressed in several structures, including embryonic/larval tracheal system; epithelium; gut section; spermatozoon; and yolk nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: 24C4-24C5; 2-11 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (3787167..3802726)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (3787167..3802726)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Transmembrane Proteins M6 and Anakonda Cooperate to Initiate Tricellular Junction Assembly in Epithelia of Drosophila.
Title: The Transmembrane Proteins M6 and Anakonda Cooperate to Initiate Tricellular Junction Assembly in Epithelia of Drosophila.
Interplay between Anakonda, Gliotactin, and M6 for Tricellular Junction Assembly and Anchoring of Septate Junctions in Drosophila Epithelium.
Title: Interplay between Anakonda, Gliotactin, and M6 for Tricellular Junction Assembly and Anchoring of Septate Junctions in Drosophila Epithelium.
Disentanglement of the neighbour cells from the midbody, and the midbody movement, are impaired in the absence of the Gliotactin (Gli) and Anakonda (Aka) TCJ proteins.
Title: Tricellular junction proteins promote disentanglement of daughter and neighbour cells during epithelial cytokinesis.
Study describes the identification and functional characterisation of the putative scavenger receptor-like protein Bark beetle (Bark; CG3921) Bark is required for septate junction (SJ) maturation in developing epithelial cells, in addition Bark controls epithelial cell adhesion within the SJ compartment.
Title: Bark beetle controls epithelial morphogenesis by septate junction maturation in Drosophila.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables carbohydrate binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in cell-cell junction maintenance	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell junction maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in liquid clearance, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of tube length, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to endoplasmic reticulum stress	HMP more info	PubMed
involved_in tricellular tight junction assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in lateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in septate junction	IDA Inferred from Direct Assay more info	PubMed
located_in septate junction	IMP Inferred from Mutant Phenotype more info	PubMed
located_in tricellular tight junction	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: bark beetle

Names: CG3921-PA; CG3921-PB; CG3921-PC; anakonda; bark-PA; bark-PB; bark-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

3787167..3802726

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001258935.3 → NP_001245864.1 bark beetle, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245864.1

Status: REVIEWED

UniProtKB/Swiss-Prot

M9NDE3, Q9VQV1

Conserved Domains (5) summary

smart00034
Location:2604 → 2699

CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)

smart00202
Location:1071 → 1175

SR; Scavenger receptor Cys-rich

cd00041
Location:459 → 552

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

pfam00530
Location:1076 → 1174

SRCR; Scavenger receptor cysteine-rich domain

pfam13229
Location:579 → 752

Beta_helix; Right handed beta helix region
NM_134964.4 → NP_608808.1 bark beetle, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_608808.1

Status: REVIEWED

UniProtKB/Swiss-Prot

M9NDE3

Related

FBpp0077185

Conserved Domains (5) summary

smart00034
Location:2596 → 2691

CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)

smart00202
Location:1071 → 1175

SR; Scavenger receptor Cys-rich

cd00041
Location:459 → 552

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

pfam00530
Location:1076 → 1174

SRCR; Scavenger receptor cysteine-rich domain

pfam13229
Location:579 → 752

Beta_helix; Right handed beta helix region
NM_001258936.2 → NP_001245865.1 bark beetle, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245865.1

Status: REVIEWED

UniProtKB/Swiss-Prot

M9NDE3, Q9VQV1

Conserved Domains (5) summary

smart00034
Location:2604 → 2699

CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)

smart00202
Location:1071 → 1175

SR; Scavenger receptor Cys-rich

cd00041
Location:459 → 552

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

pfam00530
Location:1076 → 1174

SRCR; Scavenger receptor cysteine-rich domain

pfam13229
Location:579 → 752

Beta_helix; Right handed beta helix region