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    LOC126859860 CDK7 strongly-dependent group 2 enhancer GRCh37_chr6:161025992-161027191 [ Homo sapiens (human) ]

    Gene ID: 126859860, updated on 10-Oct-2023

    Summary

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    Gene symbol
    LOC126859860
    Gene description
    CDK7 strongly-dependent group 2 enhancer GRCh37_chr6:161025992-161027191
    Gene type
    biological region
    Feature type(s)
    regulatory: enhancer
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 2 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on CDK7. [provided by RefSeq, Sep 2022]
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    Genomic context

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    Location:
    chromosome: 6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (160604960..160606159)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (161857942..161859141)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr6:160907332-160908531 Neighboring gene lipoprotein(a) like 2 (pseudogene) Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17759 Neighboring gene uncharacterized LOC124901454 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17760 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17761 Neighboring gene lipoprotein(a) Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:161106525-161107079 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17762 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr6:161158745-161159944 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25403 Neighboring gene plasminogen Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17764 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17763 Neighboring gene plasminogen-like protein B Neighboring gene NANOG hESC enhancer GRCh37_chr6:161200290-161200791 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25404 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25405 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25406 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_91154 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:161262159-161263358 Neighboring gene uncharacterized LOC112267969 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:161298543-161299475 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:161303800-161304432 Neighboring gene MPRA-validated peak6293 silencer Neighboring gene MPRA-validated peak6294 silencer Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:161309865-161310670 Neighboring gene MPRA-validated peak6295 silencer

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_084361.1 

      Range
      101..1300
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      160604960..160606159
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      161857942..161859141
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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