U.S. flag

An official website of the United States government

  • Create RSS
  • Save search
  • Advanced
  • Help
Format

Send to:

Choose Destination
    • Showing Current items.

    tax p40 [ Human T-cell leukemia virus type I ]

    Gene ID: 1491938, updated on 18-Aug-2023

    Summary

    Go to the top of the page Help
    Gene symbol
    tax
    Gene description
    p40
    Locus tag
    HTLV1gp7
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Human T-cell leukemia virus type I
    Lineage
    Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes; Ortervirales; Retroviridae; Orthoretrovirinae; Deltaretrovirus
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_001436.1 (4829..8008)

    NC_001436.1Genomic Context describing neighboring genes Neighboring gene Pr gag-pro Neighboring gene Pr gag-pro-pol Neighboring gene Pr55 Neighboring gene Neighboring gene Neighboring gene p27 Neighboring gene protein-coding

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001436.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Tax is involved in up-regulation of HMGB1 expression levels by interaction with C/EBP. Zhang CG, et al. Asian Pac J Cancer Prev, 2013. PMID 23534754
    2. Suppression of HTLV-1 replication by Tax-mediated rerouting of the p13 viral protein to nuclear speckles. Andresen V, et al. Blood, 2011 Aug 11. PMID 21677314, Free PMC Article
    3. Move or die: the fate of the Tax oncoprotein of HTLV-1. Lodewick J, et al. Viruses, 2011 Jun. PMID 21994756, Free PMC Article
    4. Activation of LTRs from different human endogenous retrovirus (HERV) families by the HTLV-1 tax protein and T-cell activators. Toufaily C, et al. Viruses, 2011 Nov. PMID 22163338, Free PMC Article
    5. Tax-dependent displacement of nucleosomes during transcriptional activation of human T-cell leukemia virus type 1. Lemasson I, et al. J Biol Chem, 2006 May 12. PMID 16547351

    See all (179) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Coevolution of HTLV-1-HBZ, Tax, and proviral load with host IRF-1 and CCNA-2 in HAM/TSP patients.
      Title: Coevolution of HTLV-1-HBZ, Tax, and proviral load with host IRF-1 and CCNA-2 in HAM/TSP patients.
    2. Interplay between innate immunity and the viral oncoproteins Tax and HBZ in the pathogenesis and therapeutic response of HTLV-1 associated adult T cell leukemia.
      Title: Interplay between innate immunity and the viral oncoproteins Tax and HBZ in the pathogenesis and therapeutic response of HTLV-1 associated adult T cell leukemia.
    3. Polymorphisms in HTLV-1 Tax-responsive elements in HTLV-1-associated myelopathy/tropical spastic paraparesis patients are associated with reduced proviral load but not with disease progression.
      Title: Polymorphisms in HTLV-1 Tax-responsive elements in HTLV-1-associated myelopathy/tropical spastic paraparesis patients are associated with reduced proviral load but not with disease progression.
    4. Evaluating mRNA expression of tax, B chain of PDGF and PDGF-beta receptors as well as HTLV-I proviral load in ATL patients and healthy carriers.
      Title: Evaluating mRNA expression of tax, B chain of PDGF and PDGF-β receptors as well as HTLV-I proviral load in ATL patients and healthy carriers.
    5. Tax Induces the Recruitment of NF-kappaB to Unintegrated HIV-1 DNA To Rescue Viral Gene Expression and Replication.
      Title: Tax Induces the Recruitment of NF-κB to Unintegrated HIV-1 DNA To Rescue Viral Gene Expression and Replication.
    6. A novel positive feedback-loop between the HTLV-1 oncoprotein Tax and NF-kappaB activity in T-cells.
      Title: A novel positive feedback-loop between the HTLV-1 oncoprotein Tax and NF-κB activity in T-cells.
    7. Adult T-cell leukemia-lymphoma as a viral disease: Subtypes based on viral aspects.
      Title: Adult T-cell leukemia-lymphoma as a viral disease: Subtypes based on viral aspects.
    8. Intragenic recruitment of NF-kappaB drives splicing modifications upon activation by the oncogene Tax of HTLV-1.
      Title: Intragenic recruitment of NF-κB drives splicing modifications upon activation by the oncogene Tax of HTLV-1.
    9. These findings suggest that both Tax and HBZ can alter the expression of EOS through undetermined mechanisms, and dysregulated expression of EOS in peripheral blood mononuclear leukocytes of HTLV-1 infected individuals may contribute to the pathological progression of HTLV-1-associated diseases.
      Title: EOS, an Ikaros family zinc finger transcription factor, interacts with the HTLV-1 oncoprotein Tax and is downregulated in peripheral blood mononuclear cells of HTLV-1-infected individuals, irrespective of clinical statuses.
    10. These findings allude to a mechanism whereby NF-kappaB-signaling regulates tubulin dynamics and mitotic instability through the modulation of p65(RelA)-Stathmin/Op-18 interactions, and support the notion that p30(II) enhances the survival of Tax-expressing HTLV-1-transformed cells.
      Title: The human T-cell leukemia virus type-1 tax oncoprotein dissociates NF-κB p65(RelA)-Stathmin complexes and causes catastrophic mitotic spindle damage and genomic instability.
    Submit: New GeneRIF Correction See all GeneRIFs (171)

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    General protein information

    Go to the top of the page Help
    Preferred Names
    p40

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001436.1 Reference assembly

      Range
      4829..8008
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_057864.1 p40 [Human T-cell leukemia virus type I]

      See identical proteins and their annotated locations for NP_057864.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O56231, P14079
      UniProtKB/TrEMBL
      A0A1D8I0X7, A0A1Y1C906, A0A1Y1CA82
      Conserved Domains (1) summary
      pfam02959
      Location:3 → 224
      Tax; HTLV Tax
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.