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    sp3a sp3a transcription factor [ Danio rerio (zebrafish) ]

    Gene ID: 558652, updated on 2-Nov-2024

    Summary

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    Official Symbol
    sp3aprovided by ZNC
    Official Full Name
    sp3a transcription factorprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070410-111
    See related
    Ensembl:ENSDARG00000001549 AllianceGenome:ZFIN:ZDB-GENE-070410-111
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    sp3; zgc:162922
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Is expressed in brain. Orthologous to human SP3 (Sp3 transcription factor). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See sp3a in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (2762268..2780249)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (2755434..2774229)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103911600 Neighboring gene sp9 transcription factor Neighboring gene cell division cycle associated 7a Neighboring gene mitogen-activated protein kinase kinase kinase 20a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Tuba1a gene expression is regulated by KLF6/7 and is necessary for CNS development and regeneration in zebrafish. Veldman MB, et al. Mol Cell Neurosci, 2010 Apr. PMID 20123021, Free PMC Article
    2. Transcriptional study reveals a potential leptin-dependent gene regulatory network in zebrafish brain. Ahi EP, et al. Fish Physiol Biochem, 2021 Aug. PMID 34236575, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC162922

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in anatomical structure morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transcription factor Sp3a
    Names
    sp3 transcription factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001089498.1 → NP_001082967.1  transcription factor Sp3a

      See identical proteins and their annotated locations for NP_001082967.1

      Status: PROVISIONAL

      Source sequence(s)
      BC139667
      UniProtKB/TrEMBL
      A0A8M1NEE1, A4QP61
      Related
      ENSDARP00000001137.8, ENSDART00000001795.9
      Conserved Domains (5) summary
      COG5048
      Location:536 → 607
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:523 → 545
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:581 → 603
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:567 → 590
      zf-H2C2_2; Zinc-finger double domain
      cl01416
      Location:113 → 218
      Fimbrial; Fimbrial protein

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      2762268..2780249
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005167417.5 → XP_005167474.1  transcription factor Sp3a isoform X1

      UniProtKB/TrEMBL
      A0A286YA94, A0A8M2BFG3
      Related
      ENSDARP00000143885.2, ENSDART00000177563.2
      Conserved Domains (5) summary
      COG5048
      Location:548 → 619
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:535 → 557
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:593 → 615
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:579 → 602
      zf-H2C2_2; Zinc-finger double domain
      cl01416
      Location:125 → 230
      Fimbrial; Fimbrial protein

    2. XM_005167418.5 → XP_005167475.1  transcription factor Sp3a isoform X2

      UniProtKB/TrEMBL
      A0A8M2BEX0
      Conserved Domains (5) summary
      COG5048
      Location:515 → 586
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:502 → 524
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:560 → 582
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:546 → 569
      zf-H2C2_2; Zinc-finger double domain
      cl01416
      Location:125 → 230
      Fimbrial; Fimbrial protein

    RNA

    1. XR_011016726.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version

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