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    sp1 sp1 transcription factor [ Danio rerio (zebrafish) ]

    Gene ID: 324109, updated on 2-Nov-2024

    Summary

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    Official Symbol
    sp1provided by ZNC
    Official Full Name
    sp1 transcription factorprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-2829
    See related
    Ensembl:ENSDARG00000088347 AllianceGenome:ZFIN:ZDB-GENE-030131-2829
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fc18h09; zgc:85950; wu:fc18h09
    Summary
    Enables DNA-binding transcription factor activity and double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Is expressed in brain; liver; spinal cord; and testis. Orthologous to human SP1 (Sp1 transcription factor). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See sp1 in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (19668..28490, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (6642..28130, complement)

    Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene myg1 exonuclease Neighboring gene proline rich 13 Neighboring gene collagen, type II, alpha 1b Neighboring gene integrin, alpha 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A hierarchic gene expression of copper homeostatic genes was demonstrated between atp7a, sp1 and sod1 in zebrafish.
      Title: Zebrafish sod1 and sp1 expression are modulated by the copper ATPase gene atp7a in response to intracellular copper status.
    2. zebrafish Sp1-like protein is structurally and functionally comparable to human Sp1
      Title: Zebrafish Sp1-like protein is structurally and functionally comparable to human Sp1.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in anatomical structure morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transcription factor Sp1
    Names
    Sp1-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212662.2 → NP_997827.2  transcription factor Sp1

      Status: VALIDATED

      Source sequence(s)
      CK139903, FP326665
      UniProtKB/TrEMBL
      A0A8M1PHF3, F1QW97
      Related
      ENSDARP00000110200.1, ENSDART00000124104.2
      Conserved Domains (4) summary
      COG5048
      Location:465 → 547
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:452 → 474
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:510 → 532
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:496 → 519
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007122.7 Reference GRCz11 Primary Assembly

      Range
      19668..28490 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021479551.2 → XP_021335226.1  transcription factor Sp1 isoform X1

      UniProtKB/TrEMBL
      A0A8M6Z917
      Conserved Domains (3) summary
      sd00017
      Location:429 → 451
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:487 → 509
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:473 → 496
      zf-H2C2_2; Zinc-finger double domain

    2. XM_017358202.2 → XP_017213691.1  transcription factor Sp1 isoform X1

      UniProtKB/TrEMBL
      A0A8M6Z917
      Conserved Domains (3) summary
      sd00017
      Location:429 → 451
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:487 → 509
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:473 → 496
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version

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