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    S large envelope protein;middle envelope protein;small envelope protein [ Hepatitis B virus ]

    Gene ID: 944569, updated on 11-Sep-2024

    Summary

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    Gene symbol
    S
    Gene description
    large envelope protein;middle envelope protein;small envelope protein
    Locus tag
    HBVgp2
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Hepatitis B virus (strain: ayw)
    Lineage
    Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes; Blubervirales; Hepadnaviridae; Orthohepadnavirus
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    Genomic context

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    Sequence:
    NC_003977.2 (2850..3182)
    NC_003977.2 (1..837)

    NC_003977.2Genomic Context describing neighboring genes Neighboring gene polymerase Neighboring gene X protein Neighboring gene capsid protein;pre-capsid protein Neighboring gene polymerase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003977.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The correlation of hepatitis B virus pre-S mutation with mitochondrial D-loop mutations and common deletions in hepatocellular carcinoma. Gwak GY, et al. Hepatogastroenterology, 2011 Mar-Apr. PMID 21661424
    2. S gene mutations of HBV in children with HBV-associated glomerulonephritis. Lu H, et al. Virol J, 2012 Mar 5. PMID 22390814, Free PMC Article
    3. Expression and purification of hepatitis B surface antigen S from Escherichia coli; a new simple method. Elghanam MS, et al. BMC Res Notes, 2012 Mar 1. PMID 22381042, Free PMC Article
    4. Differential pattern of pre-S mutations/deletions and its association with hepatitis B virus genotypes in Eastern India. Biswas A, et al. Infect Genet Evol, 2012 Mar. PMID 22266243
    5. Aberrant cyclin A expression and centrosome overduplication induced by hepatitis B virus pre-S2 mutants and its implication in hepatocarcinogenesis. Wang LH, et al. Carcinogenesis, 2012 Feb. PMID 22159224

    See all (168) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Impact of preS1 Evaluation in the Management of Chronic Hepatitis B Virus Infection.
      Title: Impact of preS1 Evaluation in the Management of Chronic Hepatitis B Virus Infection.
    2. Role of S protein transmembrane domain mutations in the development of occult hepatitis B virus infection.
      Title: Role of S protein transmembrane domain mutations in the development of occult hepatitis B virus infection.
    3. 5' preS1 Mutations To Prevent Large Envelope Protein Expression from Hepatitis B Virus Genotype A or Genotype D Markedly Increase Polymerase-Envelope Fusion Protein.
      Title: 5' preS1 Mutations To Prevent Large Envelope Protein Expression from Hepatitis B Virus Genotype A or Genotype D Markedly Increase Polymerase-Envelope Fusion Protein.
    4. Mutations in the HBV PreS/S gene related to hepatocellular carcinoma in Vietnamese chronic HBV-infected patients.
      Title: Mutations in the HBV PreS/S gene related to hepatocellular carcinoma in Vietnamese chronic HBV-infected patients.
    5. Hepatitis B Virus Small Envelope Protein Promotes Hepatocellular Carcinoma Angiogenesis via Endoplasmic Reticulum Stress Signaling To Upregulate the Expression of Vascular Endothelial Growth Factor A.
      Title: Hepatitis B Virus Small Envelope Protein Promotes Hepatocellular Carcinoma Angiogenesis via Endoplasmic Reticulum Stress Signaling To Upregulate the Expression of Vascular Endothelial Growth Factor A.
    6. Identification and Mapping of HBsAg Loss-Related B-Cell Linear Epitopes in Chronic HBV Patients by Peptide Array.
      Title: Identification and Mapping of HBsAg Loss-Related B-Cell Linear Epitopes in Chronic HBV Patients by Peptide Array.
    7. A nuanced role of the small loop of hepatitis B virus small envelope protein in virion morphogenesis and secretion.
      Title: A nuanced role of the small loop of hepatitis B virus small envelope protein in virion morphogenesis and secretion.
    8. In vitro expression of precore proteins of hepatitis B virus subgenotype A1 is affected by HBcAg, and can affect HBsAg secretion.
      Title: In vitro expression of precore proteins of hepatitis B virus subgenotype A1 is affected by HBcAg, and can affect HBsAg secretion.
    9. Identification of mutations in the S gene of hepatitis B virus in HIV positive Mexican patients with occult hepatitis B virus infection.
      Title: Identification of mutations in the S gene of hepatitis B virus in HIV positive Mexican patients with occult hepatitis B virus infection.
    10. Novel hepatitis B virus surface antigen mutations associated with occult genotype B hepatitis B virus infection affect HBsAg detection.
      Title: Novel hepatitis B virus surface antigen mutations associated with occult genotype B hepatitis B virus infection affect HBsAg detection.
    Submit: New GeneRIF Correction See all GeneRIFs (165)

    General protein information

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    Preferred Names
    large envelope protein;middle envelope protein;small envelope protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003977.2 Reference assembly

      Range
      2850..3182, 1..837
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. YP_009173869.1 large envelope protein [Hepatitis B virus]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P03138
      UniProtKB/TrEMBL
      A0A1B2G2T6, A0A1B2G2Z6, A6H2L9, C9WDA2, H6UMZ0, H6UN06, H6UN97, H6UNA1, H6UNA5, Q2F515, Q6XJW4

    2. YP_009173870.1 middle envelope protein [Hepatitis B virus]

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A1B2G2R7, A0A1B2G2T0, A6H2M0, Q6XJW3, Q8QXP8

    3. YP_009173871.1 small envelope protein [Hepatitis B virus]

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2P1E6B6, A0A7T1TSE3, H9NDB4, H9NDB9, H9NDC2, H9NDC9, I7KLX5, L7QB85, L7QCH8, O12647, O12922, Q5G8I3, Q69600
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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