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    pepO endopeptidase PepO [ Streptococcus pseudopneumoniae IS7493 ]

    Gene ID: 45218829, updated on 4-Apr-2024

    Summary

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    Gene symbol
    pepO
    Gene description
    endopeptidase PepO
    Locus tag
    SPPN_RS07935
    Gene type
    protein coding
    Organism
    Streptococcus pseudopneumoniae IS7493 (strain: IS7493)
    Lineage
    Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae; Streptococcus
    Old locus tag
    SPPN_08030
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    Genomic context

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    Sequence:
    NC_015875.1 (1544511..1546403, complement)

    NC_015875.1Genomic Context describing neighboring genes Neighboring gene LPXTG cell wall anchor domain-containing protein Neighboring gene recombinase family protein Neighboring gene ThiF family adenylyltransferase Neighboring gene MFS transporter Neighboring gene metal ABC transporter ATP-binding protein Neighboring gene metal ABC transporter permease

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_015875.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Endopeptidase PepO Regulates the SpeB Cysteine Protease and Is Essential for the Virulence of Invasive M1T1 Streptococcus pyogenes. Brouwer S, et al. J Bacteriol, 2018 Apr 15. PMID 29378883, Free PMC Article
    2. Streptococcus pneumoniae Endopeptidase O (PepO) Elicits a Strong Innate Immune Response in Mice via TLR2 and TLR4 Signaling Pathways. Zhang H, et al. Front Cell Infect Microbiol, 2016. PMID 26973817, Free PMC Article
    3. Streptococcus pneumoniae endopeptidase O (PepO) is a multifunctional plasminogen- and fibronectin-binding protein, facilitating evasion of innate immunity and invasion of host cells. Agarwal V, et al. J Biol Chem, 2013 Mar 8. PMID 23341464, Free PMC Article
    4. Whole-genome sequence of Streptococcus pseudopneumoniae isolate IS7493. Shahinas D, et al. J Bacteriol, 2011 Nov. PMID 21994930, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General protein information

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    Preferred Names
    endopeptidase PepO

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_015875.1 Reference assembly

      Range
      1544511..1546403 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. WP_014017316.1 endopeptidase PepO [Streptococcus pseudopneumoniae]

      See identical proteins and their annotated locations for WP_014017316.1

      UniProtKB/TrEMBL
      A0A2N9ZXS9
      Conserved Domains (1) summary
      COG3590
      Location:1 → 630
      PepO; Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein
    Heading Accession and Version

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