nr2c1 nuclear receptor subfamily 2, group C, member 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: nr2c1provided by ZNC
Official Full Name: nuclear receptor subfamily 2, group C, member 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-041210-198
See related: Ensembl:ENSDARG00000045527 AllianceGenome:ZFIN:ZDB-GENE-041210-198
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: TR2; zgc:110672; si:dkey-183c16.2
Summary: Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Predicted to be involved in cell differentiation and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be located in PML body. Is expressed in telencephalon. Orthologous to human NR2C1 (nuclear receptor subfamily 2 group C member 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	4	NC_007115.7 (25839277..25858638, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	4	NC_007115.6 (25850363..25869770, complement)

Chromosome 4 - NC_007115.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclear receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in PML body	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: nuclear receptor subfamily 2 group C member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001020622.1 → NP_001018458.1 nuclear receptor subfamily 2 group C member 1

See identical proteins and their annotated locations for NP_001018458.1

Status: PROVISIONAL

Source sequence(s)

BC095365

UniProtKB/TrEMBL

Q503E0

Related

ENSDARP00000131714.2, ENSDART00000159528.2

Conserved Domains (2) summary

cd06952
Location:365 → 586

NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2

cd06967
Location:108 → 194

NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007115.7 Reference GRCz11 Primary Assembly

Range

25839277..25858638 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005164817.5 → XP_005164874.1 nuclear receptor subfamily 2 group C member 1 isoform X1

UniProtKB/TrEMBL

A0A0R4IBB8, A0A8M2BC63, Q5RH32

Related

ENSDARP00000109984.2, ENSDART00000128968.4

Conserved Domains (2) summary

cd06952
Location:365 → 586

NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2

cd06967
Location:108 → 194

NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers