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    NP nucleoprotein [ Zaire ebolavirus ]

    Gene ID: 911830, updated on 18-Aug-2023

    Summary

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    Gene symbol
    NP
    Gene description
    nucleoprotein
    Locus tag
    ZEBOVgp1
    Gene type
    protein coding
    RNA name
    nucleoprotein
    RefSeq status
    PROVISIONAL
    Organism
    Zaire ebolavirus (isolate: Ebola virus/H.sapiens-tc/COD/1976/Yambuku-Mayinga)
    Lineage
    Viruses; ssRNA viruses; ssRNA negative-strand viruses; Mononegavirales; Filoviridae; Ebolavirus
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    Genomic context

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    Sequence:
    NC_002549.1 (56..3026)

    NC_002549.1Genomic Context describing neighboring genes Neighboring gene polymerase complex protein Neighboring gene matrix protein Neighboring gene second secreted glycoprotein;small secreted glycoprotein;spike glycoprotein Neighboring gene minor nucleoprotein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002549.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cryo-EM structure of the Ebola virus nucleoprotein-RNA complex. Kirchdoerfer RN, et al. Acta Crystallogr F Struct Biol Commun, 2019 May 1. PMID 31045563, Free PMC Article
    2. Cryo-EM structure of the Ebola virus nucleoprotein-RNA complex at 3.6 Å resolution. Sugita Y, et al. Nature, 2018 Nov. PMID 30333622
    3. Characterization of the Ebola virus nucleoprotein-RNA complex. Noda T, et al. J Gen Virol, 2010 Jun. PMID 20164259, Free PMC Article
    4. Enzyme-linked immunosorbent assays for detection of antibodies to Ebola and Marburg viruses using recombinant nucleoproteins. Saijo M, et al. J Clin Microbiol, 2001 Jan. PMID 11136739, Free PMC Article
    5. Analysis of linear B-cell epitopes of the nucleoprotein of ebola virus that distinguish ebola virus subtypes. Niikura M, et al. Clin Diagn Lab Immunol, 2003 Jan. PMID 12522044, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results revealed that SMYD3 was a novel host factor recruited by NP to supporting Ebola virus mRNA transcription through increasing the binding of VP30 to NP.
      Title: Host factor SMYD3 is recruited by Ebola virus nucleoprotein to facilitate viral mRNA transcription.
    2. Molecular structure of the Ebola virus nucleoprotein-RNA complex has been reported.
      Title: Cryo-EM structure of the Ebola virus nucleoprotein-RNA complex.
    3. Data show that the recombinant Ebolavirus nucleoprotein (NP) and the viral matrix protein VP40, which binds with NP, were acetylated by human histone acetyltransferases.
      Title: Acetylation of lysine residues in the recombinant nucleoprotein and VP40 matrix protein of Zaire Ebolavirus by eukaryotic histone acetyltransferases.
    4. structure of a recombinant Ebola virus nucleoprotein-RNA complex expressed in mammalian cells without chemical fixation, at near-atomic resolution using single-particle cryo-electron microscopy
      Title: Cryo-EM structure of the Ebola virus nucleoprotein-RNA complex at 3.6 Å resolution.
    5. Comparison of the percentage of disorder (PID) in nucleocapsid proteins VP30 and NP reveals high correlation between nucleocapsid PIDs and the case-fatality rates of Ebola virus .
      Title: Detection of links between Ebola nucleocapsid and virulence using disorder analysis.
    6. The authors found that the recombinant NP helix is associated with non-viral RNA, which is not protected from RNase digestion and that the morphology of the helix changes depending on the environmental salt concentration.
      Title: Characterization of the Ebola virus nucleoprotein-RNA complex.
    7. enhance our understanding of Ebola virus assembly and in so doing move us closer to the identification of targets for the development of antiviral compounds to combat Ebola virus infection
      Title: Mapping of the VP40-binding regions of the nucleoprotein of Ebola virus.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    regulatory

    • Loc: 3015-3026 regulatory_class = polyA_signal_sequence
    • Loc: 56-67 regulatory_class = other

    General protein information

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    Preferred Names
    nucleoprotein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002549.1 Reference assembly

      Range
      56..3026
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_066243.1 nucleoprotein [Zaire ebolavirus]

      See identical proteins and their annotated locations for NP_066243.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P18272, Q773N6, Q8JS64, Q9DQD3, Q9YMG4
      UniProtKB/TrEMBL
      A0A0E3KX27, A0A1L7B882, L7QHU5
      Conserved Domains (1) summary
      pfam05505
      Location:19 → 734
      Ebola_NP; Ebola nucleoprotein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    AAD14590.1

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