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    N ORF9a protein;nucleocapsid protein [ SARS coronavirus Tor2 ]

    Gene ID: 1489678, updated on 6-Jun-2024

    Summary

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    Gene symbol
    N
    Gene description
    ORF9a protein;nucleocapsid protein
    Locus tag
    sars9a
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    SARS coronavirus Tor2 (isolate: Tor2, nat-host: Homo sapiens; patient #2 with severe acute respiratory syndrome (SARS))
    Lineage
    Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes; Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae; Betacoronavirus; Sarbecovirus
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    Genomic context

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    Sequence:
    NC_004718.3 (28120..29388)

    NC_004718.3Genomic Context describing neighboring genes Neighboring gene ORF7a protein Neighboring gene ORF7b protein Neighboring gene ORF8a protein Neighboring gene ORF8b protein Neighboring gene ORF9b protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_004718.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transient oligomerization of the SARS-CoV N protein--implication for virus ribonucleoprotein packaging. Chang CK, et al. PLoS One, 2013. PMID 23717688, Free PMC Article
    2. SARS-CoV nucleocapsid protein antagonizes IFN-β response by targeting initial step of IFN-β induction pathway, and its C-terminal region is critical for the antagonism. Lu X, et al. Virus Genes, 2011 Feb. PMID 20976535, Free PMC Article
    3. The SR-rich motif in SARS-CoV nucleocapsid protein is important for virus replication. Tylor S, et al. Can J Microbiol, 2009 Mar. PMID 19370068
    4. Thermostability of the N-terminal RNA-binding domain of the SARS-CoV nucleocapsid protein: experiments and numerical simulations. Fang HJ, et al. Biophys J, 2009 Mar 4. PMID 19254548, Free PMC Article
    5. Multiple nucleic acid binding sites and intrinsic disorder of severe acute respiratory syndrome coronavirus nucleocapsid protein: implications for ribonucleocapsid protein packaging. Chang CK, et al. J Virol, 2009 Mar. PMID 19052082, Free PMC Article

    See all (74) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Using in vitro pull-down experiments and density glycerol gradients, the authors found that at least 3 regions distributed over its entire length mediate the self-interaction of mouse hepatitis virus (MHV) and severe acute respiratory syndrome coronavirus (SARS-CoV) N protein.
      Title: Coronavirus nucleocapsid proteins assemble constitutively in high molecular oligomers.
    2. The severe acute respiratory syndrome coronavirus N protein was found to bind to the SPRY domain of the tripartite motif protein 25 (TRIM25) E3 ubiquitin ligase, thereby interfering with the association between TRIM25 and retinoic acid-inducible gene I (RIG-I) and inhibiting TRIM25-mediated RIG-I ubiquitination and activation.
      Title: The Severe Acute Respiratory Syndrome Coronavirus Nucleocapsid Inhibits Type I Interferon Production by Interfering with TRIM25-Mediated RIG-I Ubiquitination.
    3. Electrostatic repulsion acts as a switch to regulate SARS virus N protein oligomerization.
      Title: Transient oligomerization of the SARS-CoV N protein--implication for virus ribonucleoprotein packaging.
    4. These results suggest that SARS coronavirus could reduce pyruvate kinase activity via its nucleocapsid protein, and this may in turn cause disease.
      Title: SARS-CoV nucleocapsid protein interacts with cellular pyruvate kinase protein and inhibits its activity.
    5. The co-localization of SARS-CoVN and CXCL16 in the cytoplasm of HEK293FT cells was also shown using confocal laser scanning microscopy.
      Title: Cxcl16 interact with SARS-CoV N protein in and out cell.
    6. The HLA-A 2402 complexed with SARSV N1 showed a novel host strategy to present an immunodominant CTL epitope by intrachain hydrogen bond as a featured epitope.
      Title: Novel immunodominant peptide presentation strategy: a featured HLA-A*2402-restricted cytotoxic T-lymphocyte epitope stabilized by intrachain hydrogen bonds from severe acute respiratory syndrome coronavirus nucleocapsid protein.
    7. SARS-CoV N interacts with MAP19 and increased the expression of MAP19 in cells.
      Title: [Study on interaction between SARS-CoV N and MAP19].
    8. SARS-CoV N protein specifically modulates transcription of the FGL2 gene to cause fibrosis and vascular thrombosis.
      Title: Severe acute respiratory syndrome coronavirus nucleocapsid protein does not modulate transcription of the human FGL2 gene.
    9. SR-rich motif is critical for effective virus replication.
      Title: The SR-rich motif in SARS-CoV nucleocapsid protein is important for virus replication.
    10. thermostability of the N-terminal RNA-binding domain (RBD) of the N protein; results showed the thermal-induced unfolding-folding transition of the RBD follows a two-state model with a reversibility >90%
      Title: Thermostability of the N-terminal RNA-binding domain of the SARS-CoV nucleocapsid protein: experiments and numerical simulations.
    Submit: New GeneRIF Correction See all GeneRIFs (45)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

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    Preferred Names
    ORF9a protein;nucleocapsid protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004718.3 Reference assembly

      Range
      28120..29388
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. YP_009825061.1 nucleocapsid protein [SARS coronavirus Tor2]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P59595, Q7T3Z4, Q7TA14, Q7TF99, Q80E50
      UniProtKB/TrEMBL
      A0A2D1PX79, A0A2D1PXA5, A0A2D1PXH1, A0A3G5BJ14, A2TGS3, B8Q8R0, B8Q8S2, B8Q8T3, B8Q8U4, B8Q8V5, B8Q8W6, C4P6R7, D2E1E2, D2E1F7, D2E230, D2E275, D2E2E7, D2E2N5, D3KDN4, Q19QW0, Q1EFM2, Q1EFN5, Q1T6X0, Q3S2B5, Q3ZTD1, Q5DIB8, Q5Y179, Q692D7, Q6GYQ2, Q6JH33, Q6JH41, Q6QJ37, Q6R7X9, Q6RCV8, Q6RCW9, Q6RCY0, Q6RCZ1, Q6RD02, Q6RD13, Q6RD24, Q6RD35, Q6RD46, Q6RD57, Q6S8C7, Q6S8E1, Q6TPE0, Q6UUW1, Q6UZE8, Q6UZF2, Q6V583, Q6VA71, Q6VA82, Q6VA93, U5WIP0, U5WLN3
      Conserved Domains (1) summary
      pfam00937
      Location:41 → 392
      Corona_nucleoca; Coronavirus nucleocapsid protein

    2. YP_009825063.1 ORF9a protein [SARS coronavirus Tor2]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q7TLC7
      UniProtKB/TrEMBL
      A0A1W6S794, C4P6R9, D2E1E4, D2E1F9, D2E218, D2E232, D2E277, D3KDN6, J9TE29, Q3S2B3, Q3ZTB5, Q3ZTC9, Q3ZTE2, Q4JDQ6, Q6S8C5, Q6S8D9, Q7TEP3
      Conserved Domains (1) summary
      cl38891
      Location:1 → 70
      SARS-CoV_ORF9c; accessory protein ORF9c (also referred to as ORF14) from Severe acute respiratory syndrome-associated coronavirus and related coronaviruses
    Nucleotide Protein
    Heading Accession and Version

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