U.S. flag

An official website of the United States government

  • Create RSS
  • Save search
  • Advanced
  • Help
Format

Send to:

Choose Destination
    • Showing Current items.

    L RNA-dependent RNA polymerase [ Zaire ebolavirus ]

    Gene ID: 911824, updated on 18-Aug-2023

    Summary

    Go to the top of the page Help
    Gene symbol
    L
    Gene description
    RNA-dependent RNA polymerase
    Locus tag
    ZEBOVgp7
    Gene type
    protein coding
    RNA name
    polymerase
    RefSeq status
    PROVISIONAL
    Organism
    Zaire ebolavirus (isolate: Ebola virus/H.sapiens-tc/COD/1976/Yambuku-Mayinga)
    Lineage
    Viruses; ssRNA viruses; ssRNA negative-strand viruses; Mononegavirales; Filoviridae; Ebolavirus
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_002549.1 (11501..18282)

    NC_002549.1Genomic Context describing neighboring genes Neighboring gene polymerase complex protein Neighboring gene matrix protein Neighboring gene second secreted glycoprotein;small secreted glycoprotein;spike glycoprotein Neighboring gene minor nucleoprotein Neighboring gene membrane-associated protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_002549.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The complete nucleotide sequence of the Popp (1967) strain of Marburg virus: a comparison with the Musoke (1980) strain. Bukreyev AA, et al. Arch Virol, 1995. PMID 7487490
    2. Ebola virus inhibits induction of genes by double-stranded RNA in endothelial cells. Harcourt BH, et al. Virology, 1998 Dec 5. PMID 9875327
    3. DNA topoisomerase 1 facilitates the transcription and replication of the Ebola virus genome. Takahashi K, et al. J Virol, 2013 Aug. PMID 23658456, Free PMC Article
    4. The L-VP35 and L-L interaction domains reside in the amino terminus of the Ebola virus L protein and are potential targets for antivirals. Trunschke M, et al. Virology, 2013 Jul 5. PMID 23582637, Free PMC Article
    5. Remdesivir targets a structurally analogous region of the Ebola virus and SARS-CoV-2 polymerases. Lo MK, et al. Proc Natl Acad Sci U S A, 2020 Oct 27. PMID 33028676, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Remdesivir targets a structurally analogous region of the Ebola virus and SARS-CoV-2 polymerases.
      Title: Remdesivir targets a structurally analogous region of the Ebola virus and SARS-CoV-2 polymerases.
    2. Authors found that the phosphodiester bridge-cleaving and recombination activities of TOP1 are required for the polymerase activity of Ebola virus L protein.
      Title: DNA topoisomerase 1 facilitates the transcription and replication of the Ebola virus genome.
    3. A core binding domain spanning amino acids 280-370 of L was sufficient to mediate weak interaction with VP35, while the entire N-terminus up to amino acid 380 was required for strong VP35-L binding.
      Title: The L-VP35 and L-L interaction domains reside in the amino terminus of the Ebola virus L protein and are potential targets for antivirals.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    regulatory

    • Loc: 11501-11512 regulatory_class = other
    • Loc: 11508-11518 regulatory_class = polyA_signal_sequence
    • Loc: 18272-18282 regulatory_class = polyA_signal_sequence

    General protein information

    Go to the top of the page Help
    Preferred Names
    RNA-dependent RNA polymerase

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002549.1 Reference assembly

      Range
      11501..18282
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_066251.1 RNA-dependent RNA polymerase [Zaire ebolavirus]

      See identical proteins and their annotated locations for NP_066251.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O39794, Q05318, Q773N0, Q8JS59, Q9DQD1
      UniProtKB/TrEMBL
      A0A0E3KN53, A0A0U3A3F9, A9QPM4, L7QHR8
      Conserved Domains (3) summary
      TIGR04198
      Location:1215 → 2204
      paramyx_RNAcap; mRNA capping enzyme, paramyxovirus family
      pfam00946
      Location:10 → 1089
      Mononeg_RNA_pol; Mononegavirales RNA dependent RNA polymerase
      pfam14318
      Location:1105 → 1357
      Mononeg_mRNAcap; Mononegavirales mRNA-capping region V
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    AAD14589.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.