hey2 hes-related family bHLH transcription factor with YRPW motif 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: hey2provided by ZNC
Official Full Name: hes-related family bHLH transcription factor with YRPW motif 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-000526-1
See related: Ensembl:ENSDARG00000013441 AllianceGenome:ZFIN:ZDB-GENE-000526-1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: grl; zgc:136746
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within with a positive effect on cardiac muscle cell proliferation. Acts upstream of or within cardiac muscle tissue regeneration; circulatory system development; and negative regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in several structures, including alar plate midbrain region; cardiovascular system; hematopoietic system; mesoderm; and nervous system. Orthologous to human HEY2 (hes related family bHLH transcription factor with YRPW motif 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (39588815..39596338, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (39686180..39693703, complement)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These data suggest a previously unappreciated role for Hey2 in controlling the proliferative capacity of cardiac progenitors.
Title: Hey2 regulates the size of the cardiac progenitor pool during vertebrate heart development.
essential role for Hey2 upstream of Notch in hematopoietic stem cell formation
Title: Hey2 acts upstream of Notch in hematopoietic stem cell specification in zebrafish embryos.
The snrk-1 gene acts downstream or parallel to notch and upstream of gridlock during artery-vein specification
Title: Snrk-1 is involved in multiple steps of angioblast development and acts via notch signaling pathway in artery-vein specification in vertebrates.
Forms a complex with Gata5 through the carboxyl region and can repress Gata5-mediated transcription.
Title: Vertebrate heart growth is regulated by functional antagonism between Gridlock and Gata5.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Notch signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within Notch signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within Notch signaling pathway involved in arterial endothelial cell fate commitment	IMP Inferred from Mutant Phenotype more info
involved_in anterior/posterior pattern specification	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within artery development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within artery morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within blood vessel development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within blood vessel development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within blood vessel morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within_positive_effect cardiac muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cardiac muscle tissue regeneration	IMP Inferred from Mutant Phenotype more info
involved_in circulatory system development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within dorsal aorta morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of DNA-templated transcription	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of neurogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within vasculogenesis	IMP Inferred from Mutant Phenotype more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: hairy/enhancer-of-split related with YRPW motif protein 2

Names: Herp2; gridlock; hairy/enhancer-of-split related with YRPW motif 2; protein gridlock

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131622.2 → NP_571697.2 hairy/enhancer-of-split related with YRPW motif protein 2

See identical proteins and their annotated locations for NP_571697.2

Status: VALIDATED

Source sequence(s)

AF237948, BC114263

UniProtKB/Swiss-Prot

Q24JW1, Q9I9L0

Related

ENSDARP00000002357.2, ENSDART00000023531.5

Conserved Domains (2) summary

cd00083
Location:49 → 105

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

pfam07527
Location:125 → 162

Hairy_orange; Hairy Orange