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    etv1 ETS variant transcription factor 1 [ Danio rerio (zebrafish) ]

    Gene ID: 563876, updated on 2-Nov-2024

    Summary

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    Official Symbol
    etv1provided by ZNC
    Official Full Name
    ETS variant transcription factor 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070104-1
    See related
    Ensembl:ENSDARG00000101959 AllianceGenome:ZFIN:ZDB-GENE-070104-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in cell differentiation and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in brain; lens placode; posterior pancreatic bud; and trigeminal ganglion. Orthologous to human ETV1 (ETS variant transcription factor 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See etv1 in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (34173973..34214286, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (34318831..34356391, complement)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene von Willebrand factor D and EGF domains Neighboring gene si:dkey-30e9.6 Neighboring gene ADP-ribosylation factor-like 4aa Neighboring gene uncharacterized LOC137487770 Neighboring gene diacylglycerol kinase, beta Neighboring gene alkylglycerol monooxygenase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Validating in utero electroporation for the rapid analysis of gene regulatory elements in the murine telencephalon. Langevin LM, et al. Dev Dyn, 2007 May. PMID 17377980
    2. Divergence in regulation of the PEA3 family of ETS transcription factors. Roussigné M, et al. Gene Expr Patterns, 2006 Oct. PMID 16516559
    3. Transcriptional enhancement of Smn levels in motoneurons is crucial for proper axon morphology in zebrafish. Spiró Z, et al. Sci Rep, 2016 Jun 7. PMID 27273160, Free PMC Article
    4. LIN28B regulates transcription and potentiates MYCN-induced neuroblastoma through binding to ZNF143 at target gene promotors. Tao T, et al. Proc Natl Acad Sci U S A, 2020 Jul 14. PMID 32601179, Free PMC Article
    5. Function of strawberry notch family genes in the zebrafish brain development. Takano A, et al. Kobe J Med Sci, 2011 Feb 2. PMID 21937870

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. er81 embryonic expression regulation does not require FGF signalling.
      Title: Divergence in regulation of the PEA3 family of ETS transcription factors.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ETS translocation variant 1
    Names
    ETS transcription factor Er81
    er81
    ets variant gene 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001030182.1 → NP_001025353.1  ETS translocation variant 1

      See identical proteins and their annotated locations for NP_001025353.1

      Status: PROVISIONAL

      Source sequence(s)
      AY997531
      UniProtKB/TrEMBL
      Q4VCI4
      Related
      ENSDARP00000145233.1, ENSDART00000191945.1
      Conserved Domains (2) summary
      smart00413
      Location:338 → 388
      ETS; erythroblast transformation specific domain
      pfam04621
      Location:1 → 330
      ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      34173973..34214286 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005157634.5 → XP_005157691.1  ETS translocation variant 1 isoform X1

      See identical proteins and their annotated locations for XP_005157691.1

      UniProtKB/TrEMBL
      A0A8M2B3T7, B3DIF9
      Related
      ENSDARP00000129920.1, ENSDART00000167052.3
      Conserved Domains (2) summary
      smart00413
      Location:333 → 417
      ETS; erythroblast transformation specific domain
      pfam04621
      Location:1 → 332
      ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain

    2. XM_005157635.5 → XP_005157692.1  ETS translocation variant 1 isoform X2

      See identical proteins and their annotated locations for XP_005157692.1

      UniProtKB/TrEMBL
      A0A8M2B3T9
      Conserved Domains (2) summary
      smart00413
      Location:293 → 377
      ETS; erythroblast transformation specific domain
      pfam04621
      Location:21 → 292
      ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain

    3. XM_009291802.4 → XP_009290077.1  ETS translocation variant 1 isoform X2

      See identical proteins and their annotated locations for XP_009290077.1

      UniProtKB/TrEMBL
      A0A8M2B3T9
      Conserved Domains (2) summary
      smart00413
      Location:293 → 377
      ETS; erythroblast transformation specific domain
      pfam04621
      Location:21 → 292
      ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version

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