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    Dl dorsal [ Apis mellifera (honey bee) ]

    Gene ID: 406086, updated on 20-Nov-2023

    Summary

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    Gene symbol
    Dl
    Gene description
    dorsal
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Apis mellifera
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea; Anthophila; Apidae; Apis
    Also known as
    GB19066; GB19537; GB30211; GB44031
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    Genomic context

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    Location:
    chromosome: LG4
    Exon count:
    16
    Annotation release Status Assembly LG Location
    104 current Amel_HAv3.1 (GCF_003254395.2) LG4 NC_037641.1 (11095375..11108126)
    103 previous assembly Amel_4.5 (GCF_000002195.4) LG4 NC_007073.3 (10569657..10580396, complement)

    Linkage Group LG4 - NC_037641.1Genomic Context describing neighboring genes Neighboring gene vacuolar protein sorting-associated protein 35 Neighboring gene apoptosis-resistant E3 ubiquitin protein ligase 1 Neighboring gene leucine-rich repeat-containing protein 26 Neighboring gene keratin, type II cytoskeletal 74 Neighboring gene acidic leucine-rich nuclear phosphoprotein 32 family member B Neighboring gene uncharacterized LOC107964291 Neighboring gene ribosomal protein L36A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Silencing of Apis mellifera dorsal genes reveals their role in expression of the antimicrobial peptide defensin-1. Lourenço AP, et al. Insect Mol Biol, 2018 Oct. PMID 29663584
    2. Differential expression of endogenous plant cell wall degrading enzyme genes in the stick insect (Phasmatodea) midgut. Shelomi M, et al. BMC Genomics, 2014 Oct 21. PMID 25331961, Free PMC Article
    3. Insights into social insects from the genome of the honeybee Apis mellifera. Honeybee Genome Sequencing Consortium. Nature, 2006 Oct 26. PMID 17073008, Free PMC Article
    4. ProtoBee: hierarchical classification and annotation of the honey bee proteome. Kaplan N, et al. Genome Res, 2006 Nov. PMID 17065614, Free PMC Article
    5. Finding the missing honey bee genes: lessons learned from a genome upgrade. Elsik CG, et al. BMC Genomics, 2014 Jan 30. PMID 24479613, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. regulates expression of defensin-1 but not abaecin
      Title: Silencing of Apis mellifera dorsal genes reveals their role in expression of the antimicrobial peptide defensin-1.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cellular response to stress IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in non-canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in response to cytokine IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dorsal protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001011577.1 → NP_001011577.1  dorsal protein isoform A

      See identical proteins and their annotated locations for NP_001011577.1

      Status: VALIDATED

      Source sequence(s)
      AY268030
      UniProtKB/TrEMBL
      A0A7M6UE89, A0A8B6WYX4, A0A8U1BWE7, Q86DH7
      Conserved Domains (2) summary
      cd07887
      Location:45 → 218
      RHD-n_Dorsal_Dif; N-terminal sub-domain of the Rel homology domain (RHD) of the arthropod protein Dorsal
      pfam16179
      Location:224 → 325
      RHD_dimer; Rel homology dimerization domain

    2. NM_001171006.1 → NP_001164477.1  dorsal protein isoform B

      See identical proteins and their annotated locations for NP_001164477.1

      Status: VALIDATED

      Source sequence(s)
      AY268031
      UniProtKB/TrEMBL
      A0A7M7GZM9, A0A7M7LP21, A0A8B6Z3J8, A0A8B6Z3K0, Q86DH6
      Conserved Domains (2) summary
      cd07887
      Location:45 → 218
      RHD-n_Dorsal_Dif; N-terminal sub-domain of the Rel homology domain (RHD) of the arthropod protein Dorsal
      pfam16179
      Location:225 → 325
      RHD_dimer; Rel homology dimerization domain

    RefSeqs of Annotated Genomes: Apis mellifera Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Amel_HAv3.1 Primary Assembly

    Genomic

    1. NC_037641.1 Reference Amel_HAv3.1 Primary Assembly

      Range
      11095375..11108126
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006566999.3 → XP_006567062.1  dorsal protein isoform X1

      See identical proteins and their annotated locations for XP_006567062.1

      UniProtKB/TrEMBL
      A0A7M7GZM9, A0A7M7LP21, A0A8B6Z3J8, A0A8B6Z3K0, Q86DH6
      Conserved Domains (2) summary
      cd07887
      Location:45 → 218
      RHD-n_Dorsal_Dif; N-terminal sub-domain of the Rel homology domain (RHD) of the arthropod protein Dorsal
      pfam16179
      Location:225 → 325
      RHD_dimer; Rel homology dimerization domain

    2. XM_006567000.3 → XP_006567063.1  dorsal protein isoform X1

      See identical proteins and their annotated locations for XP_006567063.1

      UniProtKB/TrEMBL
      A0A7M7GZM9, A0A7M7LP21, A0A8B6Z3J8, A0A8B6Z3K0, Q86DH6
      Conserved Domains (2) summary
      cd07887
      Location:45 → 218
      RHD-n_Dorsal_Dif; N-terminal sub-domain of the Rel homology domain (RHD) of the arthropod protein Dorsal
      pfam16179
      Location:225 → 325
      RHD_dimer; Rel homology dimerization domain

    3. XM_006566998.3 → XP_006567061.1  dorsal protein isoform X1

      See identical proteins and their annotated locations for XP_006567061.1

      UniProtKB/TrEMBL
      A0A7M7GZM9, A0A7M7LP21, A0A8B6Z3J8, A0A8B6Z3K0, Q86DH6
      Conserved Domains (2) summary
      cd07887
      Location:45 → 218
      RHD-n_Dorsal_Dif; N-terminal sub-domain of the Rel homology domain (RHD) of the arthropod protein Dorsal
      pfam16179
      Location:225 → 325
      RHD_dimer; Rel homology dimerization domain

    4. XM_006567002.3 → XP_006567065.1  dorsal protein isoform X2

      UniProtKB/TrEMBL
      A0A7M7GZU8, A0A8B6Z574
      Conserved Domains (2) summary
      cd07887
      Location:45 → 218
      RHD-n_Dorsal_Dif; N-terminal sub-domain of the Rel homology domain (RHD) of the arthropod protein Dorsal
      pfam16179
      Location:224 → 325
      RHD_dimer; Rel homology dimerization domain

    5. XM_006566997.3 → XP_006567060.1  dorsal protein isoform X1

      See identical proteins and their annotated locations for XP_006567060.1

      UniProtKB/TrEMBL
      A0A7M7GZM9, A0A7M7LP21, A0A8B6Z3J8, A0A8B6Z3K0, Q86DH6
      Conserved Domains (2) summary
      cd07887
      Location:45 → 218
      RHD-n_Dorsal_Dif; N-terminal sub-domain of the Rel homology domain (RHD) of the arthropod protein Dorsal
      pfam16179
      Location:225 → 325
      RHD_dimer; Rel homology dimerization domain
    Nucleotide Protein Strain
    Heading Accession and Version

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