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    Zfp54 zinc finger protein 54 [ Mus musculus (house mouse) ]

    Gene ID: 22712, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Zfp54provided by MGI
    Official Full Name
    zinc finger protein 54provided by MGI
    Primary source
    MGI:MGI:99201
    See related
    Ensembl:ENSMUSG00000023882 AllianceGenome:MGI:99201
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Zfp76; KRAB10; Zfp-54; mszf83; 2810034D10Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; frenulum; genitourinary system; liver; and spleen. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in bladder adult (RPKM 1.9), testis adult (RPKM 1.3) and 24 other tissues See more
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    Genomic context

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    See Zfp54 in Genome Data Viewer
    Location:
    17 A3.2; 17 11.4 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (21643489..21655646)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (21423227..21435384)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 677 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E7494 Neighboring gene zinc finger protein 677 Neighboring gene crumbs homolog 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_42007 Neighboring gene STARR-positive B cell enhancer ABC_E9941 Neighboring gene STARR-positive B cell enhancer ABC_E8655 Neighboring gene zinc finger protein 51 Neighboring gene STARR-seq mESC enhancer starr_42008 Neighboring gene STARR-seq mESC enhancer starr_42009 Neighboring gene predicted gene, 52290

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Localization and differential expression of the Krüppel-associated box zinc finger proteins 1 and 54 in early mouse development. Albertsen M, et al. DNA Cell Biol, 2010 Oct. PMID 20624068
    2. Molecular characterization of Zfp54, a zinc-finger-containing gene that is deleted in the embryonic lethal mutation tw18. Shannon M, et al. Mamm Genome, 1999 Jul. PMID 10384051
    3. A cluster of related zinc finger protein genes is deleted in the mouse embryonic lethal mutation tw18. Crossley PH, et al. Proc Natl Acad Sci U S A, 1991 Sep 15. PMID 1680234, Free PMC Article
    4. Physical analysis of the region deleted in the tw18 allele of the mouse tcl-4 complementation group. Barclay J, et al. Genomics, 1996 Aug 15. PMID 8812414
    5. Emergence of the ZNF91 Krüppel-associated box-containing zinc finger gene family in the last common ancestor of anthropoidea. Bellefroid EJ, et al. Proc Natl Acad Sci U S A, 1995 Nov 7. PMID 7479878, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Taken together, this suggests a role for ZFP1 and ZFP54 in transcriptional regulation in early development.
      Title: Localization and differential expression of the Krüppel-associated box zinc finger proteins 1 and 54 in early mouse development.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC91117

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 54
    Names
    Krueppel-associated box protein 10
    clone 18
    zinc finger protein 76

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001379356.1 → NP_001366285.1  zinc finger protein 54 isoform 1

      Status: VALIDATED

      Source sequence(s)
      CT009594, CT010433
      UniProtKB/Swiss-Prot
      E9PW05, O88631, Q66JT2, Q6R5P4
      Related
      ENSMUSP00000132983.2, ENSMUST00000165230.8
      Conserved Domains (4) summary
      COG5048
      Location:98 → 504
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:491 → 571
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:469 → 489
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:12 → 52
      KRAB; KRAB box

    2. NM_001379357.1 → NP_001366286.1  zinc finger protein 54 isoform 1

      Status: VALIDATED

      Source sequence(s)
      CT009594, CT010433
      UniProtKB/Swiss-Prot
      E9PW05, O88631, Q66JT2, Q6R5P4
      Conserved Domains (4) summary
      COG5048
      Location:98 → 504
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:491 → 571
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:469 → 489
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:12 → 52
      KRAB; KRAB box

    3. NM_001379358.1 → NP_001366287.1  zinc finger protein 54 isoform 1

      Status: VALIDATED

      Source sequence(s)
      CT009594, CT010433
      UniProtKB/Swiss-Prot
      E9PW05, O88631, Q66JT2, Q6R5P4
      Conserved Domains (4) summary
      COG5048
      Location:98 → 504
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:491 → 571
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:469 → 489
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:12 → 52
      KRAB; KRAB box

    4. NM_001379359.1 → NP_001366288.1  zinc finger protein 54 isoform 2

      Status: VALIDATED

      Source sequence(s)
      CT009594, CT010433
      Conserved Domains (4) summary
      COG5048
      Location:138 → 544
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:531 → 611
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:509 → 529
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:52 → 92
      KRAB; KRAB box

    5. NM_011760.2 → NP_035890.2  zinc finger protein 54 isoform 1

      See identical proteins and their annotated locations for NP_035890.2

      Status: VALIDATED

      Source sequence(s)
      CT009594, CT010433
      Consensus CDS
      CCDS37462.1
      UniProtKB/Swiss-Prot
      E9PW05, O88631, Q66JT2, Q6R5P4
      Related
      ENSMUSP00000007884.9, ENSMUST00000007884.15
      Conserved Domains (4) summary
      COG5048
      Location:98 → 504
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:491 → 571
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:469 → 489
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:12 → 52
      KRAB; KRAB box

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      21643489..21655646
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030249760.1 → XP_030105620.1  zinc finger protein 54 isoform X1

      Conserved Domains (3) summary
      COG5048
      Location:21 → 427
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:414 → 494
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:392 → 412
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E9PW05.1 GenPept UniProtKB/Swiss-Prot:E9PW05

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