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Rasgrp3 RAS, guanyl releasing protein 3 [ Mus musculus (house mouse) ]

Gene ID: 240168, updated on 2-Nov-2024

Summary

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Official Symbol
Rasgrp3provided by MGI
Official Full Name
RAS, guanyl releasing protein 3provided by MGI
Primary source
MGI:MGI:3028579
See related
Ensembl:ENSMUSG00000071042 AllianceGenome:MGI:3028579
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm327
Summary
Enables guanyl-nucleotide exchange factor activity; kinase binding activity; and small GTPase binding activity. Acts upstream of or within Ras protein signal transduction. Located in perinuclear region of cytoplasm. Part of guanyl-nucleotide exchange factor complex. Is expressed in cerebral cortex ventricular layer; embryo; and thymus primordium. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human RASGRP3 (RAS guanyl releasing protein 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in lung adult (RPKM 6.2), heart adult (RPKM 3.5) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Rasgrp3 in Genome Data Viewer
Location:
17 E2; 17 46.55 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (75742849..75836049)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (75435870..75529054)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31818 Neighboring gene STARR-seq mESC enhancer starr_43233 Neighboring gene latent transforming growth factor beta binding protein 1 Neighboring gene STARR-seq mESC enhancer starr_43235 Neighboring gene ribosomal protein L19 pseudogene Neighboring gene STARR-seq mESC enhancer starr_43238 Neighboring gene STARR-positive B cell enhancer ABC_E9966 Neighboring gene STARR-seq mESC enhancer starr_43240 Neighboring gene STARR-positive B cell enhancer ABC_E10971 Neighboring gene STARR-seq mESC enhancer starr_43241 Neighboring gene STARR-positive B cell enhancer ABC_E4226 Neighboring gene STARR-seq mESC enhancer starr_43242 Neighboring gene STARR-positive B cell enhancer ABC_E8697 Neighboring gene STARR-positive B cell enhancer ABC_E9443 Neighboring gene STARR-positive B cell enhancer ABC_E5628 Neighboring gene STARR-positive B cell enhancer ABC_E7558 Neighboring gene STARR-positive B cell enhancer ABC_E143 Neighboring gene predicted gene, 53979 Neighboring gene family with sequence similarity 98, member A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. RasGRP3 limits Toll-like receptor-triggered inflammatory response in macrophages by activating Rap1 small GTPase. Tang S, et al. Nat Commun, 2014 Aug 14. PMID 25118589, Free PMC Article
  2. The Ras activator RasGRP3 mediates diabetes-induced embryonic defects and affects endothelial cell migration. Randhawa PK, et al. Circ Res, 2011 May 13. PMID 21474816, Free PMC Article
  3. RasGRP1 and RasGRP3 Are Required for Efficient Generation of Early Thymic Progenitors. Golec DP, et al. J Immunol, 2016 Sep 1. PMID 27465532
  4. RasGRP1 and RasGRP3 regulate B cell proliferation by facilitating B cell receptor-Ras signaling. Coughlin JJ, et al. J Immunol, 2005 Dec 1. PMID 16301621
  5. RasGRP1, but not RasGRP3, is required for efficient thymic β-selection and ERK activation downstream of CXCR4. Golec DP, et al. PLoS One, 2013. PMID 23308188, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RasGRP3 is specifically required for GNAQ/GNA11-driven Ras activation and tumorigenesis.
    Title: GNA11 Q209L Mouse Model Reveals RasGRP3 as an Essential Signaling Node in Uveal Melanoma.
  2. RasGRP1/3-deficient progenitors show impaired migration toward the CCR9 ligand, CCL25, suggesting that RasGRP1 and RasGRP3 may regulate progenitor entry into the thymus through a CCR9-dependent mechanism.
    Title: RasGRP1 and RasGRP3 Are Required for Efficient Generation of Early Thymic Progenitors.
  3. RasGRP3 limits inflammatory response by activating Rap1 on low-intensity pathogen infection, setting a threshold for preventing excessive inflammatory response.
    Title: RasGRP3 limits Toll-like receptor-triggered inflammatory response in macrophages by activating Rap1 small GTPase.
  4. RasGRP1, but not RasGRP3, is required for thymocyte positive selection and invariant natural killer T cell selection.
    Title: RasGRP1, but not RasGRP3, is required for efficient thymic β-selection and ERK activation downstream of CXCR4.
  5. Expressed in developing blood vessels, Rasgrp3 contributes to the incidence of cardiovascular defects found in embryos from diabetic mothers.
    Title: The Ras activator RasGRP3 mediates diabetes-induced embryonic defects and affects endothelial cell migration.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Clone Names

  • MGC74365, MGC79207

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within Ras protein signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
part_of guanyl-nucleotide exchange factor complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ras guanyl-releasing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166493.2 → NP_001159965.1  ras guanyl-releasing protein 3

    See identical proteins and their annotated locations for NP_001159965.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC118018, CT010501
    Consensus CDS
    CCDS37695.1
    UniProtKB/TrEMBL
    Q69ZX7, Q6NZH9
    Related
    ENSMUSP00000129393.2, ENSMUST00000164192.9
    Conserved Domains (4) summary
    cd06224
    Location:11 → 126
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    smart00147
    Location:148 → 384
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00029
    Location:495 → 544
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam13499
    Location:428 → 478
    EF-hand_7; EF-hand domain pair

  2. NM_001360103.1 → NP_001347032.1  ras guanyl-releasing protein 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    CT010501
    Consensus CDS
    CCDS37695.1
    UniProtKB/TrEMBL
    Q69ZX7, Q6NZH9
    Conserved Domains (4) summary
    cd06224
    Location:11 → 126
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    smart00147
    Location:148 → 384
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00029
    Location:495 → 544
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam13499
    Location:428 → 478
    EF-hand_7; EF-hand domain pair

  3. NM_001411230.1 → NP_001398159.1  ras guanyl-releasing protein 3

    Status: VALIDATED

    Source sequence(s)
    AC118018, CT010501
    UniProtKB/TrEMBL
    Q6NZH9

  4. NM_207246.4 → NP_997129.1  ras guanyl-releasing protein 3

    See identical proteins and their annotated locations for NP_997129.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    BC066069, BY123705, CJ131259
    Consensus CDS
    CCDS37695.1
    UniProtKB/TrEMBL
    Q69ZX7, Q6NZH9
    Related
    ENSMUSP00000092828.5, ENSMUST00000095204.6
    Conserved Domains (4) summary
    cd06224
    Location:11 → 126
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    smart00147
    Location:148 → 384
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00029
    Location:495 → 544
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam13499
    Location:428 → 478
    EF-hand_7; EF-hand domain pair

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    75742849..75836049
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524273.4 → XP_006524336.1  ras guanyl-releasing protein 3 isoform X2

    See identical proteins and their annotated locations for XP_006524336.1

    UniProtKB/TrEMBL
    Q69ZX7
    Conserved Domains (4) summary
    cd06224
    Location:11 → 126
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    smart00147
    Location:148 → 384
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd00029
    Location:494 → 543
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam13499
    Location:427 → 477
    EF-hand_7; EF-hand domain pair
Nucleotide Protein Strain
Heading Accession and Version

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