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PCNX3 pecanex 3 [ Homo sapiens (human) ]

Gene ID: 399909, updated on 2-Nov-2024

Summary

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Official Symbol
PCNX3provided by HGNC
Official Full Name
pecanex 3provided by HGNC
Primary source
HGNC:HGNC:18760
See related
Ensembl:ENSG00000197136 MIM:617657; AllianceGenome:HGNC:18760
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PCNXL3
Summary
Predicted to be located in membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis (RPKM 9.4), spleen (RPKM 6.0) and 25 other tissues See more
Orthologs
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Genomic context

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See PCNX3 in Genome Data Viewer
Location:
11q13.1
Exon count:
37
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (65615776..65637439)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (65608472..65631609)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (65383247..65404910)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene potassium two pore domain channel subfamily K member 7 Neighboring gene mitogen-activated protein kinase kinase kinase 11 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3544 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:65380127-65381014 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3545 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:65381903-65382789 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4994 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4995 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4996 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3546 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:65404393-65405183 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3547 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4997 Neighboring gene microRNA 4690 Neighboring gene signal-induced proliferation-associated 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3548 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4998 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4999 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:65421552-65422052 Neighboring gene microRNA 4489 Neighboring gene RELA proto-oncogene, NF-kB subunit Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3549 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3550 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5000 Neighboring gene RELA divergent transcript

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. ENTREP/FAM189A2 encodes a new ITCH ubiquitin ligase activator that is downregulated in breast cancer. Tsunoda T, et al. EMBO Rep, 2022 Feb 3. PMID 34927784, Free PMC Article
  2. Novel interactors and a role for supervillin in early cytokinesis. Smith TC, et al. Cytoskeleton (Hoboken), 2010 Jun. PMID 20309963, Free PMC Article
  3. A Hypoxia-Induced SCFFBXL1 E3 Ligase Ubiquitinates and Degrades the MEN1 Tumor Suppressor to Promote Colorectal Cancer Tumorigenesis. Zeng J, et al. Cancer Res Treat, 2022 Apr. PMID 34237211, Free PMC Article
  4. Engagement of the G3BP2-TRIM25 Interaction by Nucleocapsid Protein Suppresses the Type I Interferon Response in SARS-CoV-2-Infected Cells. Yang Z, et al. Vaccines (Basel), 2022 Nov 29. PMID 36560452, Free PMC Article
  5. Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer. Mavaddat N, et al. Cancer Epidemiol Biomarkers Prev, 2009 Jan. PMID 19124506, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
  2. Observational study of gene-disease association. (HuGE Navigator)
    Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Discovery and refinement of loci associated with lipid levels.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • FLJ22427

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
pecanex-like protein 3
Names
pecanex homolog 3
pecanex homolog protein 3
pecanex-like 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032223.4 → NP_115599.2  pecanex-like protein 3

    See identical proteins and their annotated locations for NP_115599.2

    Status: VALIDATED

    Source sequence(s)
    AP001362, KF455405
    Consensus CDS
    CCDS44650.1
    UniProtKB/Swiss-Prot
    Q6MZN8, Q9H6A9
    Related
    ENSP00000347931.3, ENST00000355703.4
    Conserved Domains (1) summary
    pfam05041
    Location:1570 → 1795
    Pecanex_C; Pecanex protein (C-terminus)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    65615776..65637439
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011545024.3 → XP_011543326.1  pecanex-like protein 3 isoform X1

    See identical proteins and their annotated locations for XP_011543326.1

    Conserved Domains (1) summary
    pfam05041
    Location:1583 → 1808
    Pecanex_C; Pecanex protein (C-terminus)

  2. XM_006718549.5 → XP_006718612.1  pecanex-like protein 3 isoform X3

    Conserved Domains (1) summary
    pfam05041
    Location:1577 → 1802
    Pecanex_C; Pecanex protein (C-terminus)

  3. XM_005273987.6 → XP_005274044.1  pecanex-like protein 3 isoform X2

    Conserved Domains (2) summary
    pfam05041
    Location:1582 → 1807
    Pecanex_C; Pecanex protein (C-terminus)
    cl21589
    Location:419 → 626
    Relaxase; Relaxase/Mobilization nuclease domain

  4. XM_047426937.1 → XP_047282893.1  pecanex-like protein 3 isoform X4

  5. XM_047426938.1 → XP_047282894.1  pecanex-like protein 3 isoform X5

  6. XM_011545025.4 → XP_011543327.1  pecanex-like protein 3 isoform X6

    Conserved Domains (2) summary
    pfam05041
    Location:1583 → 1808
    Pecanex_C; Pecanex protein (C-terminus)
    cl21589
    Location:419 → 622
    Relaxase; Relaxase/Mobilization nuclease domain

  7. XM_047426939.1 → XP_047282895.1  pecanex-like protein 3 isoform X7

  8. XM_011545028.4 → XP_011543330.1  pecanex-like protein 3 isoform X8

    Conserved Domains (2) summary
    PHA03247
    Location:194 → 629
    PHA03247; large tegument protein UL36; Provisional
    COG1289
    Location:850 → 1043
    YccC; Uncharacterized membrane protein YccC [Function unknown]

  9. XM_005273990.6 → XP_005274047.1  pecanex-like protein 3 isoform X9

    Conserved Domains (2) summary
    PHA03247
    Location:194 → 629
    PHA03247; large tegument protein UL36; Provisional
    COG1289
    Location:850 → 1043
    YccC; Uncharacterized membrane protein YccC [Function unknown]

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    65608472..65631609
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054368754.1 → XP_054224729.1  pecanex-like protein 3 isoform X1

  2. XM_054368756.1 → XP_054224731.1  pecanex-like protein 3 isoform X3

  3. XM_054368755.1 → XP_054224730.1  pecanex-like protein 3 isoform X2

  4. XM_054368757.1 → XP_054224732.1  pecanex-like protein 3 isoform X4

  5. XM_054368758.1 → XP_054224733.1  pecanex-like protein 3 isoform X5

  6. XM_054368759.1 → XP_054224734.1  pecanex-like protein 3 isoform X6

  7. XM_054368760.1 → XP_054224735.1  pecanex-like protein 3 isoform X7

  8. XM_054368761.1 → XP_054224736.1  pecanex-like protein 3 isoform X8

  9. XM_054368762.1 → XP_054224737.1  pecanex-like protein 3 isoform X9

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H6A9.2 GenPept UniProtKB/Swiss-Prot:Q9H6A9

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