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    Nit2 nitrilase family, member 2 [ Mus musculus (house mouse) ]

    Gene ID: 52633, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Nit2provided by MGI
    Official Full Name
    nitrilase family, member 2provided by MGI
    Primary source
    MGI:MGI:1261838
    See related
    Ensembl:ENSMUSG00000022751 AllianceGenome:MGI:1261838
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D16Ertd502e; 1190017B19Rik
    Summary
    Predicted to enable omega-amidase activity. Predicted to be involved in asparagine metabolic process; glutamine metabolic process; and oxaloacetate metabolic process. Located in mitochondrion. Orthologous to human NIT2 (nitrilase family member 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in liver adult (RPKM 44.0), kidney adult (RPKM 21.9) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nit2 in Genome Data Viewer
    Location:
    16 C1.1; 16 34.22 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (56977028..56987695, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (57156665..57167332, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 45A2 Neighboring gene STARR-positive B cell enhancer ABC_E1927 Neighboring gene translocase of outer mitochondrial membrane 70A Neighboring gene STARR-seq mESC enhancer starr_41078 Neighboring gene STARR-positive B cell enhancer ABC_E8637 Neighboring gene predicted gene, 16892 Neighboring gene TBC1 domain family, member 23 Neighboring gene STARR-positive B cell enhancer ABC_E11617 Neighboring gene STARR-positive B cell enhancer mm9_chr16:57231379-57231680 Neighboring gene STARR-seq mESC enhancer starr_41080 Neighboring gene STARR-seq mESC enhancer starr_41081 Neighboring gene STARR-seq mESC enhancer starr_41082 Neighboring gene transmembrane protein 30C Neighboring gene STARR-seq mESC enhancer starr_41083 Neighboring gene predicted gene, 26800

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Molecular identification of omega-amidase, the enzyme that is functionally coupled with glutamine transaminases, as the putative tumor suppressor Nit2. Jaisson S, et al. Biochimie, 2009 Sep. PMID 19596042
    2. Functional proteomic and structural insights into molecular recognition in the nitrilase family enzymes. Barglow KT, et al. Biochemistry, 2008 Dec 23. PMID 19053248, Free PMC Article
    3. Crystal structure of the worm NitFhit Rosetta Stone protein reveals a Nit tetramer binding two Fhit dimers. Pace HC, et al. Curr Biol, 2000 Jul 27-Aug 10. PMID 10959838
    4. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
    5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data conclude that mammalian nitrilase 2 is omega-amidase.
      Title: Molecular identification of omega-amidase, the enzyme that is functionally coupled with glutamine transaminases, as the putative tumor suppressor Nit2.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 2-oxoglutaramate amidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables omega-amidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables omega-amidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables omega-amidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in asparagine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in asparagine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in asparagine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glutamine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glutamine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in oxaloacetate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in oxaloacetate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in oxaloacetate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    omega-amidase NIT2
    Names
    Nit protein 2
    nitrilase homolog 2
    NP_075664.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023175.1 → NP_075664.1  omega-amidase NIT2

      See identical proteins and their annotated locations for NP_075664.1

      Status: PROVISIONAL

      Source sequence(s)
      AF284573
      Consensus CDS
      CCDS37363.1
      UniProtKB/Swiss-Prot
      Q9CTG9, Q9JHW2
      Related
      ENSMUSP00000023432.9, ENSMUST00000023432.10
      Conserved Domains (1) summary
      cd07572
      Location:5 → 265
      nit; Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      56977028..56987695 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JHW2.1 GenPept UniProtKB/Swiss-Prot:Q9JHW2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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