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    Mfsd4b5 major facilitator superfamily domain containing 4B5 [ Mus musculus (house mouse) ]

    Gene ID: 215928, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Mfsd4b5provided by MGI
    Official Full Name
    major facilitator superfamily domain containing 4B5provided by MGI
    Primary source
    MGI:MGI:2446139
    See related
    Ensembl:ENSMUSG00000038528 AllianceGenome:MGI:2446139
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Naglt1c
    Summary
    Predicted to enable D-glucose transmembrane transporter activity. Orthologous to human MFSD4B (major facilitator superfamily domain containing 4B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in kidney adult (RPKM 30.0) and placenta adult (RPKM 3.9) See more
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    Genomic context

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    See Mfsd4b5 in Genome Data Viewer
    Location:
    10 B1; 10 21.37 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (39834057..39862642, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (39958061..39986646, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene major facilitator superfamily domain containing 4B2 Neighboring gene major facilitator superfamily domain containing 4B3, pseudogene Neighboring gene neutrophil immunoglobulin-like receptor 1 Neighboring gene STARR-positive B cell enhancer ABC_E5125 Neighboring gene STARR-seq mESC enhancer starr_26408 Neighboring gene major facilitator superfamily domain containing 4B1 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene solute carrier family 16 (monocarboxylic acid transporters), member 10 Neighboring gene STARR-seq mESC enhancer starr_26410 Neighboring gene predicted gene, 25613

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables D-glucose transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables D-glucose transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    sodium-dependent glucose transporter 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001489.3 → NP_001001489.1  sodium-dependent glucose transporter 1 isoform b

      See identical proteins and their annotated locations for NP_001001489.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate splice site in the 3' region, resulting in a novel 3' coding region and shorter 3' UTR, compared to variant 1. The encoded isoform (b) is shorter and has a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AC168279, AK085266
      Consensus CDS
      CCDS23791.1
      UniProtKB/TrEMBL
      Q8C3P4, Q8VC53
      Related
      ENSMUSP00000130944.2, ENSMUST00000164566.8

    2. NM_001113385.1 → NP_001106856.1  sodium-dependent glucose transporter 1 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AC168279, AI527856, AK085266
      Consensus CDS
      CCDS48542.1
      UniProtKB/TrEMBL
      E9PYY6
      Related
      ENSMUSP00000126439.2, ENSMUST00000170579.9
      Conserved Domains (2) summary
      cd06174
      Location:38 → 445
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:41 → 408
      MFS_1; Major Facilitator Superfamily

    3. NM_001113388.2 → NP_001106859.1  sodium-dependent glucose transporter 1 isoform c

      See identical proteins and their annotated locations for NP_001106859.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has an alternate 3' terminal exon, compared to variant 1. The encoded isoform (c) is shorter and has a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AK085266, AK165493
      Consensus CDS
      CCDS48541.1
      UniProtKB/TrEMBL
      Q3TN71, Q8VC53
      Related
      ENSMUSP00000073304.6, ENSMUST00000073618.13

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      39834057..39862642 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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