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    GOLGA8O golgin A8 family member O [ Homo sapiens (human) ]

    Gene ID: 728047, updated on 2-Nov-2024

    Summary

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    Official Symbol
    GOLGA8Oprovided by HGNC
    Official Full Name
    golgin A8 family member Oprovided by HGNC
    Primary source
    HGNC:HGNC:44406
    See related
    Ensembl:ENSG00000206127 AllianceGenome:HGNC:44406
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to be involved in Golgi organization. Predicted to be located in Golgi apparatus. Predicted to be active in Golgi cis cisterna; Golgi cisterna membrane; and cis-Golgi network. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in thyroid (RPKM 29.8), testis (RPKM 14.9) and 23 other tissues See more
    Orthologs
    all
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    Genomic context

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    See GOLGA8O in Genome Data Viewer
    Location:
    15q13.3
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (32441914..32461984, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (30238452..30258301, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (32734115..32747835, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene 15q13.2-13.3 gamma inversion distal recombination region Neighboring gene ULK4 pseudogene 1 Neighboring gene U8 small nucleolar RNA Neighboring gene dynamin 1 pseudogene 32 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:32738857-32739358 Neighboring gene RNA, 7SL, cytoplasmic 539, pseudogene Neighboring gene uncharacterized LOC100289543 Neighboring gene uncharacterized LOC124903456 Neighboring gene uncharacterized LOC105376710 Neighboring gene golgin subfamily A member 6-like protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Golgins in the structure and dynamics of the Golgi apparatus. Barr FA, et al. Curr Opin Cell Biol, 2003 Aug. PMID 12892780
    2. A physical interaction network of dengue virus and human proteins. Khadka S, et al. Mol Cell Proteomics, 2011 Dec. PMID 21911577, Free PMC Article
    3. The golgin coiled-coil proteins of the Golgi apparatus. Munro S. Cold Spring Harb Perspect Biol, 2011 Jun 1. PMID 21436057, Free PMC Article
    4. Analysis of the DNA sequence and duplication history of human chromosome 15. Zody MC, et al. Nature, 2006 Mar 30. PMID 16572171
    5. The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch. Kawashima AT, et al. Mol Cell Biol, 2021 Feb 23. PMID 33397691, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See Variation Viewer (GRCh37.p13)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi cis cisterna IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in Golgi cisterna membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cis-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    golgin subfamily A member 8O
    Names
    Golgin subfamily A member 6-like protein 11
    Golgin subfamily A member 8O

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001277308.1 → NP_001264237.1  golgin subfamily A member 8O

      See identical proteins and their annotated locations for NP_001264237.1

      Status: VALIDATED

      Source sequence(s)
      AC135983, BQ477899, DB068178
      Consensus CDS
      CCDS59252.1
      UniProtKB/Swiss-Prot
      A6NCC3, A6NHZ1, E7ENU5
      UniProtKB/TrEMBL
      A0A0J9YX86
      Related
      ENSP00000423159.2, ENST00000509311.7
      Conserved Domains (1) summary
      pfam15070
      Location:226 → 622
      GOLGA2L5; Putative golgin subfamily A member 2-like protein 5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      32441914..32461984 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024450042.2 → XP_024305810.1  golgin subfamily A member 8O isoform X3

      Conserved Domains (1) summary
      pfam15070
      Location:75 → 471
      GOLGA2L5; Putative golgin subfamily A member 2-like protein 5

    2. XM_011521988.4 → XP_011520290.1  golgin subfamily A member 8O isoform X2

      UniProtKB/TrEMBL
      A0A0J9YX86
      Conserved Domains (1) summary
      pfam15070
      Location:226 → 599
      GOLGA2L5; Putative golgin subfamily A member 2-like protein 5

    3. XM_047433006.1 → XP_047288962.1  golgin subfamily A member 8O isoform X1

    4. XM_011521989.4 → XP_011520291.1  golgin subfamily A member 8O isoform X4

      Conserved Domains (1) summary
      pfam01496
      Location:272 → 362
      V_ATPase_I; V-type ATPase 116kDa subunit family

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_012132920.1 Reference GRCh38.p14 PATCHES

      Range
      1960410..1980238 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054331873.1 → XP_054187848.1  golgin subfamily A member 8O isoform X3

    2. XM_054331871.1 → XP_054187846.1  golgin subfamily A member 8O isoform X2

    3. XM_054331870.1 → XP_054187845.1  golgin subfamily A member 8O isoform X1

    4. XM_054331872.1 → XP_054187847.1  golgin subfamily A member 8O isoform X5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      30238452..30258301 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054378743.1 → XP_054234718.1  golgin subfamily A member 8O isoform X3

    2. XM_054378742.1 → XP_054234717.1  golgin subfamily A member 8O isoform X2

    3. XM_054378741.1 → XP_054234716.1  golgin subfamily A member 8O isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A6NCC3.3 GenPept UniProtKB/Swiss-Prot:A6NCC3

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