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    Cyp3a57 cytochrome P450, family 3, subfamily a, polypeptide 57 [ Mus musculus (house mouse) ]

    Gene ID: 622127, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Cyp3a57provided by MGI
    Official Full Name
    cytochrome P450, family 3, subfamily a, polypeptide 57provided by MGI
    Primary source
    MGI:MGI:3646373
    See related
    Ensembl:ENSMUSG00000070419 AllianceGenome:MGI:3646373
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EG622127
    Summary
    Predicted to enable testosterone 16-alpha-hydroxylase activity and testosterone 6-beta-hydroxylase activity. Predicted to be involved in oxidative demethylation and steroid metabolic process. Orthologous to human CYP3A43 (cytochrome P450 family 3 subfamily A member 43). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in bladder adult (RPKM 5.6), mammary gland adult (RPKM 3.0) and 2 other tissues See more
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    Genomic context

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    See Cyp3a57 in Genome Data Viewer
    Location:
    5 G2; 5 85.17 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (145281959..145327736)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (145345149..145390926)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6398 Neighboring gene predicted gene 9710 Neighboring gene zinc finger and SCAN domain containing 25 Neighboring gene STARR-seq mESC enhancer starr_14828 Neighboring gene STARR-seq mESC enhancer starr_14829 Neighboring gene STARR-seq mESC enhancer starr_14831 Neighboring gene STARR-seq mESC enhancer starr_14833 Neighboring gene sperm motility kinase 3A pseudogene Neighboring gene cytochrome P450, family 3, subfamily a, polypeptide 16

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Trans-chromosomic mice containing a human CYP3A cluster for prediction of xenobiotic metabolism in humans. Kazuki Y, et al. Hum Mol Genet, 2013 Feb 1. PMID 23125282
    2. Knockout of cytochrome P450 3A yields new mouse models for understanding xenobiotic metabolism. van Herwaarden AE, et al. J Clin Invest, 2007 Nov. PMID 17975676, Free PMC Article
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables testosterone 16-alpha-hydroxylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables testosterone 6-beta-hydroxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables testosterone 6-beta-hydroxylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in oxidative demethylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in steroid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450, family 3, subfamily a, polypeptide 57

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100180.2 → NP_001093650.1  cytochrome P450, family 3, subfamily a, polypeptide 57

      Status: VALIDATED

      Source sequence(s)
      AC115895, AC127411
      Consensus CDS
      CCDS39388.1
      UniProtKB/TrEMBL
      D3YYZ0, Q9QXK4
      Related
      ENSMUSP00000078251.8, ENSMUST00000079268.9
      Conserved Domains (1) summary
      pfam00067
      Location:39 → 493
      p450; Cytochrome P450

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      145281959..145327736
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504852.3 → XP_006504915.1  cytochrome P450, family 3, subfamily a, polypeptide 57 isoform X2

      Conserved Domains (1) summary
      cl12078
      Location:39 → 342
      p450; Cytochrome P450

    2. XM_030254747.1 → XP_030110607.1  cytochrome P450, family 3, subfamily a, polypeptide 57 isoform X3

      Conserved Domains (1) summary
      cl12078
      Location:39 → 202
      p450; Cytochrome P450

    3. XM_006504849.4 → XP_006504912.1  cytochrome P450, family 3, subfamily a, polypeptide 57 isoform X1

      UniProtKB/TrEMBL
      Q9QXK4
      Conserved Domains (1) summary
      pfam00067
      Location:39 → 455
      p450; Cytochrome P450
    Nucleotide Protein
    Heading Accession and Version

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