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    GBP1 guanylate binding protein 1 [ Homo sapiens (human) ]

    Gene ID: 2633, updated on 3-Nov-2024

    Summary

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    Official Symbol
    GBP1provided by HGNC
    Official Full Name
    guanylate binding protein 1provided by HGNC
    Primary source
    HGNC:HGNC:4182
    See related
    Ensembl:ENSG00000117228 MIM:600411; AllianceGenome:HGNC:4182
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    hGBP1
    Summary
    Guanylate binding protein expression is induced by interferon. Guanylate binding proteins are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP) and are distinguished from the GTP-binding proteins by the presence of 2 binding motifs rather than 3. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in appendix (RPKM 60.1), lymph node (RPKM 37.4) and 24 other tissues See more
    Orthologs
    all
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    Genomic context

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    See GBP1 in Genome Data Viewer
    Location:
    1p22.2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (89052319..89065208, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (88895700..88908571, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (89518002..89530891, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904215 Neighboring gene guanylate binding protein 3 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:89487936-89489135 Neighboring gene NANOG hESC enhancer GRCh37_chr1:89496021-89496522 Neighboring gene uncharacterized LOC105378841 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1294 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:89516373-89516957 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:89521826-89523025 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1295 Neighboring gene Sharpr-MPRA regulatory region 5145 Neighboring gene prostaglandin E synthase 3 pseudogene 1 Neighboring gene uncharacterized LOC112268267 Neighboring gene guanylate binding protein 2 Neighboring gene Sharpr-MPRA regulatory region 4932

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Human GBP1 does not localize to pathogen vacuoles but restricts Toxoplasma gondii. Johnston AC, et al. Cell Microbiol, 2016 Aug. PMID 26874079, Free PMC Article
    2. hGBP1 Coordinates Chlamydia Restriction and Inflammasome Activation through Sequential GTP Hydrolysis. Xavier A, et al. Cell Rep, 2020 May 19. PMID 32433976
    3. Catalytic activity of human guanylate-binding protein 1 coupled to the release of structural restraints imposed by the C-terminal domain. Ince S, et al. FEBS J, 2021 Jan. PMID 32352209
    4. The alpha helix of the intermediate region in hGBP-1 acts as a coupler for enhanced GMP formation. Rajan S, et al. Biochim Biophys Acta Proteins Proteom, 2020 May. PMID 31954926
    5. Guanylate binding protein 1 (GBP-1) promotes cell motility and invasiveness of lung adenocarcinoma. Yamakita I, et al. Biochem Biophys Res Commun, 2019 Oct 15. PMID 31421831

    See all (124) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Guanylate-binding protein 1 inhibits Hantaan virus infection by restricting virus entry.
      Title: Guanylate-binding protein 1 inhibits Hantaan virus infection by restricting virus entry.
    2. GBP1 promotes cutaneous squamous cell carcinoma proliferation and invasion through activation of STAT3 by SP1.
      Title: GBP1 promotes cutaneous squamous cell carcinoma proliferation and invasion through activation of STAT3 by SP1.
    3. Interferon-gamma-induced GBP1 is an inhibitor of human papillomavirus 18.
      Title: Interferon-γ-induced GBP1 is an inhibitor of human papillomavirus 18.
    4. Guanylate-binding protein 1 acts as a pro-viral factor for the life cycle of hepatitis C virus.
      Title: Guanylate-binding protein 1 acts as a pro-viral factor for the life cycle of hepatitis C virus.
    5. Function and mechanism of GBP1 in the development and progression of cervical cancer.
      Title: Function and mechanism of GBP1 in the development and progression of cervical cancer.
    6. Human GBP1 facilitates the rupture of the Legionella-containing vacuole and inflammasome activation.
      Title: Human GBP1 facilitates the rupture of the Legionella-containing vacuole and inflammasome activation.
    7. BRCA1-associated RING domain-1 (BARD1) loss and GBP1 expression enhance sensitivity to DNA damage in Ewing sarcoma.
      Title: BRCA1-associated RING domain-1 (BARD1) loss and GBP1 expression enhance sensitivity to DNA damage in Ewing sarcoma.
    8. Human GBP1 Is Involved in the Repair of Damaged Phagosomes/Endolysosomes.
      Title: Human GBP1 Is Involved in the Repair of Damaged Phagosomes/Endolysosomes.
    9. Differential expression of interferon inducible protein: Guanylate binding protein (GBP1 & GBP2) in severe dengue.
      Title: Differential expression of interferon inducible protein: Guanylate binding protein (GBP1 & GBP2) in severe dengue.
    10. Guanylate Binding Protein 1 (GBP1): A Key Protein in Inflammatory Pyroptosis.
      Title: Guanylate Binding Protein 1 (GBP1): A Key Protein in Inflammatory Pyroptosis.
    Submit: New GeneRIF Correction See all GeneRIFs (90)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 downregulates the expression of interferon-inducible guanylate-binding protein 1 (GBP1) in human B cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GDP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GDP phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables Hsp90 protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables actin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cytokine binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables lipopolysaccharide binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables spectrin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to interleukin-1 IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular response to tumor necrosis factor IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular response to type II interferon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to type II interferon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cytolysis in another organism IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in defense response to bacterium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in defense response to bacterium ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in defense response to protozoan IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in defense response to virus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in innate immune response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of T cell receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of interleukin-2 production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of substrate adhesion-dependent cell spreading IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in non-canonical inflammasome complex assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of pyroptotic inflammatory response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein localization to vacuole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of calcium-mediated signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of protein localization to plasma membrane IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in symbiont cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in vesicle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in vesicle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    guanylate-binding protein 1
    Names
    GBP-1
    GTP-binding protein 1
    guanine nucleotide-binding protein 1
    guanylate binding protein 1, interferon-inducible, 67kDa
    huGBP-1
    interferon-induced guanylate-binding protein 1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002053.3 → NP_002044.2  guanylate-binding protein 1

      See identical proteins and their annotated locations for NP_002044.2

      Status: VALIDATED

      Source sequence(s)
      AK291783, BF058809, CB164272, CD676970
      Consensus CDS
      CCDS718.1
      UniProtKB/Swiss-Prot
      D3DT26, P32455, Q5T8M1
      UniProtKB/TrEMBL
      Q5D1D5
      Related
      ENSP00000359504.4, ENST00000370473.5
      Conserved Domains (3) summary
      pfam02841
      Location:284 → 580
      GBP_C; Guanylate-binding protein, C-terminal domain
      pfam02263
      Location:18 → 282
      GBP; Guanylate-binding protein, N-terminal domain
      cd16269
      Location:290 → 580
      GBP_C; Guanylate-binding protein, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      89052319..89065208 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      88895700..88908571 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32455.2 GenPept UniProtKB/Swiss-Prot:P32455

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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