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    LOC126805603 CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:7798026-7799225 [ Homo sapiens (human) ]

    Gene ID: 126805603, updated on 10-Oct-2023

    Summary

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    Gene symbol
    LOC126805603
    Gene description
    CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:7798026-7799225
    Gene type
    biological region
    Feature type(s)
    regulatory: enhancer
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 2 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on CDK7. [provided by RefSeq, Sep 2022]
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    Genomic context

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    See LOC126805603 in Genome Data Viewer
    Location:
    chromosome: 1
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (7737966..7739165)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (7269012..7270211)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene calmodulin binding transcription activator 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:7563077-7563934 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:7563935-7564790 Neighboring gene uncharacterized LOC105376691 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:7565577-7566214 Neighboring gene MPRA-validated peak35 silencer Neighboring gene MPRA-validated peak36 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:7594027-7595006 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:7598278-7598983 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:7643497-7643996 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:7646449-7647169 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:7655704-7656204 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:7668502-7669038 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:7670114-7670651 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:7669577-7670113 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:7669039-7669576 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:7672975-7673506 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:7673507-7674037 Neighboring gene MPRA-validated peak37 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:7685250-7685750 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:7695174-7696155 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:7700515-7701015 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:7702117-7703085 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:7703871-7704371 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:7710763-7711264 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:7711265-7711764 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:7717029-7717568 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:7723269-7723770 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 90 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:7729239-7730085 Neighboring gene translation initiation factor IF-2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 185 Neighboring gene MPRA-validated peak40 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:7830560-7831256 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:7831283-7831525 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 186 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 187 Neighboring gene uncharacterized LOC124903833 Neighboring gene MPRA-validated peak42 silencer Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:7886590-7887789 Neighboring gene vesicle associated membrane protein 3 Neighboring gene period circadian regulator 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_081927.1 

      Range
      101..1300
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      7737966..7739165
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      7269012..7270211
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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