ARPC1A actin related protein 2/3 complex subunit 1A [Homo sapiens (human)] - Gene

Summary

Official Symbol: ARPC1Aprovided by HGNC
Official Full Name: actin related protein 2/3 complex subunit 1Aprovided by HGNC
Primary source: HGNC:HGNC:703
See related: Ensembl:ENSG00000241685 MIM:604220; AllianceGenome:HGNC:703
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: Arc40; SOP2L; HEL-68; SOP2Hs; HEL-S-307
Summary: This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1B. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Expression: Ubiquitous expression in thyroid (RPKM 48.9), stomach (RPKM 46.5) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 7q22.1

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (99325898..99366262)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (100564792..100605160)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (98923521..98963885)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ARPC1A is regulated by STAT3 to inhibit ferroptosis and promote prostate cancer progression.
Title: ARPC1A is regulated by STAT3 to inhibit ferroptosis and promote prostate cancer progression.
Development and validation of hub genes for lymph node metastasis in patients with prostate cancer.
Title: Development and validation of hub genes for lymph node metastasis in patients with prostate cancer.
Genome-wide association study of gene-disease association. (HuGE Navigator)
Title: Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease.
data implicate ARPC1A as a novel target for the 7q21-q22 amplification and a regulator of cell migration and invasion in pancreatic cancer
Title: Characterization of the 7q21-q22 amplicon identifies ARPC1A, a subunit of the Arp2/3 complex, as a regulator of cell migration and invasion in pancreatic cancer.
Observational study of gene-disease association. (HuGE Navigator)
Title: Lack of association between UGT1A7, UGT1A9, ARP, SPINK1 and CFTR gene polymorphisms and pancreatic cancer in Italian patients.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of actin related protein 2/3 complex, subunit 1A, 41kDa (ARPC1A) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH11961 (e-PCR)
- UniSTS:42016

D7S2721 (e-PCR)
- UniSTS:59284

SHGC-5612 (e-PCR)
- UniSTS:90086

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables actin binding	TAS Traceable Author Statement more info	PubMed
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Arp2/3 complex-mediated actin nucleation	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin cytoskeleton organization	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of Arp2/3 protein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Arp2/3 protein complex	ISS Inferred from Sequence or Structural Similarity more info
located_in actin cytoskeleton	TAS Traceable Author Statement more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in extracellular exosome	HDA more info	PubMed
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
located_in muscle cell projection membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in site of double-strand break	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: actin-related protein 2/3 complex subunit 1A

Names: SOP2-like protein; actin binding protein (Schizosaccharomyces pombe sop2-like); actin related protein 2/3 complex, subunit 1A, 41kDa; epididymis luminal protein 68; epididymis secretory protein Li 307; epididymis secretory sperm binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001190996.2 → NP_001177925.1 actin-related protein 2/3 complex subunit 1A isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks 2 nts at an alternate splice site in the 5' region, as compared to variant 1. The resulting isoform (2) is shorter and has a different N-terminus, as compared to isoform 1.

Source sequence(s)

BC006445, DA089818

UniProtKB/TrEMBL

A0A0K0K1L3, Q53GB6

Conserved Domains (3) summary

COG2319
Location:1 → 351

WD40; WD40 repeat [General function prediction only]

sd00039
Location:42 → 79

7WD40; WD40 repeat [structural motif]

cl02567
Location:32 → 274

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_006409.4 → NP_006400.2 actin-related protein 2/3 complex subunit 1A isoform 1

See identical proteins and their annotated locations for NP_006400.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

BC039594, BC054027, DA089818

Consensus CDS

CCDS5660.1

UniProtKB/Swiss-Prot

A4D276, B4DLQ7, D6W5S1, Q7Z5U8, Q86WU5, Q8IXQ0, Q92747

UniProtKB/TrEMBL

A0A0K0K1L3, Q53GB6, V9HVZ6

Related

ENSP00000262942.5, ENST00000262942.10

Conserved Domains (2) summary

sd00039
Location:11 → 50

7WD40; WD40 repeat [structural motif]

cl29593
Location:46 → 288

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...