MICALL2 MICAL like 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MICALL2provided by HGNC
Official Full Name: MICAL like 2provided by HGNC
Primary source: HGNC:HGNC:29672
See related: Ensembl:ENSG00000164877 MIM:620912; AllianceGenome:HGNC:29672
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: JRAB; MICAL-L2
Summary: Enables filamin binding activity. Involved in positive regulation of protein targeting to mitochondrion. Predicted to be located in several cellular components, including bicellular tight junction; recycling endosome; and stress fiber. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in spleen (RPKM 13.4), small intestine (RPKM 10.9) and 23 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 7p22.3

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (1434359..1459470, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (1545546..1571603, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (1473995..1499106, complement)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Comprehensive Analysis of MICALL2 Reveals Its Potential Roles in EGFR Stabilization and Ovarian Cancer Cell Invasion.
Title: Comprehensive Analysis of MICALL2 Reveals Its Potential Roles in EGFR Stabilization and Ovarian Cancer Cell Invasion.
MICALL2 as a substrate of ubiquitinase TRIM21 regulates tumorigenesis of colorectal cancer.
Title: MICALL2 as a substrate of ubiquitinase TRIM21 regulates tumorigenesis of colorectal cancer.
JRAB/MICAL-L2 undergoes liquid-liquid phase separation to form tubular recycling endosomes.
Title: JRAB/MICAL-L2 undergoes liquid-liquid phase separation to form tubular recycling endosomes.
Up-regulation of MICAL-L2 is associated with gastric cancer cell migration.
Title: MICAL-L2 potentiates Cdc42-dependent EGFR stability and promotes gastric cancer cell migration.
We identified one new significant locus at 7p22.3 for the Stroop word interference time (rs11514810, P=3.42E-09 for discovery, P=0.01176 for replication and combined P=5.249E-09). Regulatory feature analysis and expression quantitative trait loci (eQTL) data showed that this locus contributes to MICALL2 expression in the human brain.
Title: A new locus regulating MICALL2 expression was identified for association with executive inhibition in children with attention deficit hyperactivity disorder.
Data indicate that MICAL-L2 may be an important regulator of epithelial-mesenchymal transition (EMT) in ovarian cancer cells.
Title: Silencing of MICAL-L2 suppresses malignancy of ovarian cancer by inducing mesenchymal-epithelial transition.
Involved in epithelial cell scattering.
Title: Involvement of Rab13 and JRAB/MICAL-L2 in epithelial cell scattering.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Clone Names

FLJ23471, FLJ41996, FLJ44858, FLJ45410, MGC46023

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables actin filament binding	ISS Inferred from Sequence or Structural Similarity more info
enables actinin binding	IEA Inferred from Electronic Annotation more info
enables filamin binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in actin filament polymerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in bicellular tight junction assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in endocytic recycling	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuron projection development	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein targeting to mitochondrion	HMP more info	PubMed
involved_in substrate adhesion-dependent cell spreading	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
colocalizes_with actin filament bundle	ISS Inferred from Sequence or Structural Similarity more info
located_in bicellular tight junction	ISS Inferred from Sequence or Structural Similarity more info
located_in cell-cell junction	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in neuron projection	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in recycling endosome	ISS Inferred from Sequence or Structural Similarity more info
colocalizes_with stress fiber	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: MICAL-like protein 2

Names: junctional Rab13-binding protein; molecule interacting with CasL-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_182924.4 → NP_891554.1 MICAL-like protein 2

See identical proteins and their annotated locations for NP_891554.1

Status: VALIDATED

Source sequence(s)

AK027124, AK074068, AY358755, BC037988, DA945802

Consensus CDS

CCDS5324.1

UniProtKB/Swiss-Prot

D3YTD2, Q7RTP4, Q7Z655, Q8IY33, Q8TEQ4, Q9H5F9

Related

ENSP00000297508.7, ENST00000297508.8

Conserved Domains (4) summary

cd09444
Location:188 → 241

LIM_Mical_like_1; This domain belongs to the LIM domain family which are found on Mical (molecule interacting with CasL) like proteins

pfam00307
Location:5 → 102

CH; Calponin homology (CH) domain

pfam12130
Location:736 → 872

DUF3585; Protein of unknown function (DUF3585)

pfam12325
Location:784 → 879

TMF_TATA_bd; TATA element modulatory factor 1 TATA binding

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000007.14 Reference GRCh38.p14 Primary Assembly

Range

1434359..1459470 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047420838.1 → XP_047276794.1 MICAL-like protein 2 isoform X3
XM_047420836.1 → XP_047276792.1 MICAL-like protein 2 isoform X1
XM_047420837.1 → XP_047276793.1 MICAL-like protein 2 isoform X2

Related

ENSP00000405415.1, ENST00000413446.5

RNA

XR_002956487.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

NC_060931.1 Alternate T2T-CHM13v2.0

Range

1545546..1571603 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054359005.1 → XP_054214980.1 MICAL-like protein 2 isoform X3
XM_054359004.1 → XP_054214979.1 MICAL-like protein 2 isoform X1

RNA

XR_008487754.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_024723.1: Suppressed sequence

Description

NM_024723.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.