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    BICRAL BICRA like chromatin remodeling complex associated protein [ Homo sapiens (human) ]

    Gene ID: 23506, updated on 2-Nov-2024

    Summary

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    Official Symbol
    BICRALprovided by HGNC
    Official Full Name
    BICRA like chromatin remodeling complex associated proteinprovided by HGNC
    Primary source
    HGNC:HGNC:21111
    See related
    Ensembl:ENSG00000112624 MIM:618502; AllianceGenome:HGNC:21111
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SMARCK2; GLTSCR1L; KIAA0240
    Summary
    Predicted to be involved in positive regulation of DNA-templated transcription. Part of SWI/SNF complex. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary (RPKM 8.6), thyroid (RPKM 7.9) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See BICRAL in Genome Data Viewer
    Location:
    6p21.1
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (42746339..42868556)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (42575724..42697274)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (42714725..42836294)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ATPase H+ transporting V0 subunit c pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24566 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24567 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24568 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:42713934-42714897 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24569 Neighboring gene putative uncharacterized protein encoded by LINC00269 Neighboring gene tubulin folding cofactor C Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17207 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24570 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:42750599-42751288 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:42751289-42751978 Neighboring gene uncharacterized LOC401261 Neighboring gene MPRA-validated peak5810 silencer Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr6:42846366-42847323 and GRCh37_chr6:42847324-42848280 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24575 Neighboring gene ribosomal protein L7 like 1 Neighboring gene peroxisomal biogenesis factor 39

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A non-canonical BRD9-containing BAF chromatin remodeling complex regulates naive pluripotency in mouse embryonic stem cells. Gatchalian J, et al. Nat Commun, 2018 Dec 3. PMID 30510198, Free PMC Article
    2. Glioma tumor suppressor candidate region gene 1 (GLTSCR1) and its paralog GLTSCR1-like form SWI/SNF chromatin remodeling subcomplexes. Alpsoy A, et al. J Biol Chem, 2018 Mar 16. PMID 29374058, Free PMC Article
    3. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. Nagase T, et al. DNA Res, 1996 Oct 31. PMID 9039502
    4. Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs. Nakayama M, et al. Genome Res, 2002 Nov. PMID 12421765, Free PMC Article
    5. Spindle Assembly Checkpoint Inhibition Can Resensitize p53-Null Stem Cells to Cancer Chemotherapy. Liu C, et al. Cancer Res, 2019 May 1. PMID 30862715, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0240, DKFZp686P0250

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin remodeling NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of cell differentiation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cell population proliferation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of stem cell population maintenance NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of GBAF complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of SWI/SNF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SWI/SNF complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromatin NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    BRD4-interacting chromatin-remodeling complex-associated protein-like
    Names
    BRD4 interacting chromatin remodeling complex associated protein like
    BRD4 interacting chromatin remodelling complex associated protein like
    GLTSCR1 like
    glioma tumor suppressor candidate region gene 1 protein-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_054763.1 RefSeqGene

      Range
      40095..126599
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001318819.2 → NP_001305748.1  BRD4-interacting chromatin-remodeling complex-associated protein-like

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AL353716, AW168030, D87077
      Consensus CDS
      CCDS34451.1
      UniProtKB/Swiss-Prot
      A1L3W2, Q5TFZ3, Q6AI39, Q92514
      Conserved Domains (1) summary
      pfam15249
      Location:711 → 811
      GLTSCR1; Conserved region of unknown function on GLTSCR protein

    2. NM_001393499.1 → NP_001380428.1  BRD4-interacting chromatin-remodeling complex-associated protein-like

      Status: VALIDATED

      Source sequence(s)
      AL035587, AL353716
      Consensus CDS
      CCDS34451.1
      UniProtKB/Swiss-Prot
      A1L3W2, Q5TFZ3, Q6AI39, Q92514
      Related
      ENSP00000313933.4, ENST00000314073.10
      Conserved Domains (1) summary
      pfam15249
      Location:711 → 811
      GLTSCR1; Conserved region of unknown function on GLTSCR protein

    3. NM_015349.3 → NP_056164.1  BRD4-interacting chromatin-remodeling complex-associated protein-like

      See identical proteins and their annotated locations for NP_056164.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK093526, AL833540, AW168030, BC015724, BC047630
      Consensus CDS
      CCDS34451.1
      UniProtKB/Swiss-Prot
      A1L3W2, Q5TFZ3, Q6AI39, Q92514
      Related
      ENSP00000377723.1, ENST00000394168.1
      Conserved Domains (1) summary
      pfam15249
      Location:711 → 811
      GLTSCR1; Conserved region of unknown function on GLTSCR protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      42746339..42868556
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047418544.1 → XP_047274500.1  BRD4-interacting chromatin-remodeling complex-associated protein-like isoform X2

    2. XM_047418547.1 → XP_047274503.1  BRD4-interacting chromatin-remodeling complex-associated protein-like isoform X3

    3. XM_047418542.1 → XP_047274498.1  BRD4-interacting chromatin-remodeling complex-associated protein-like isoform X2

    4. XM_047418545.1 → XP_047274501.1  BRD4-interacting chromatin-remodeling complex-associated protein-like isoform X2

    5. XM_047418543.1 → XP_047274499.1  BRD4-interacting chromatin-remodeling complex-associated protein-like isoform X2

    6. XM_024446390.2 → XP_024302158.1  BRD4-interacting chromatin-remodeling complex-associated protein-like isoform X1

      UniProtKB/Swiss-Prot
      A1L3W2, Q5TFZ3, Q6AI39, Q92514
      Conserved Domains (1) summary
      pfam15249
      Location:711 → 811
      GLTSCR1; Conserved region of unknown function on GLTSCR protein

    RNA

    1. XR_007059228.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      42575724..42697274
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054354967.1 → XP_054210942.1  BRD4-interacting chromatin-remodeling complex-associated protein-like isoform X1

      UniProtKB/Swiss-Prot
      A1L3W2, Q5TFZ3, Q6AI39, Q92514

    2. XM_054354961.1 → XP_054210936.1  BRD4-interacting chromatin-remodeling complex-associated protein-like isoform X1

      UniProtKB/Swiss-Prot
      A1L3W2, Q5TFZ3, Q6AI39, Q92514

    3. XM_054354962.1 → XP_054210937.1  BRD4-interacting chromatin-remodeling complex-associated protein-like isoform X1

      UniProtKB/Swiss-Prot
      A1L3W2, Q5TFZ3, Q6AI39, Q92514

    4. XM_054354968.1 → XP_054210943.1  BRD4-interacting chromatin-remodeling complex-associated protein-like isoform X1

      UniProtKB/Swiss-Prot
      A1L3W2, Q5TFZ3, Q6AI39, Q92514

    5. XM_054354964.1 → XP_054210939.1  BRD4-interacting chromatin-remodeling complex-associated protein-like isoform X1

      UniProtKB/Swiss-Prot
      A1L3W2, Q5TFZ3, Q6AI39, Q92514

    6. XM_054354963.1 → XP_054210938.1  BRD4-interacting chromatin-remodeling complex-associated protein-like isoform X1

      UniProtKB/Swiss-Prot
      A1L3W2, Q5TFZ3, Q6AI39, Q92514

    7. XM_054354965.1 → XP_054210940.1  BRD4-interacting chromatin-remodeling complex-associated protein-like isoform X1

      UniProtKB/Swiss-Prot
      A1L3W2, Q5TFZ3, Q6AI39, Q92514

    8. XM_054354966.1 → XP_054210941.1  BRD4-interacting chromatin-remodeling complex-associated protein-like isoform X1

      UniProtKB/Swiss-Prot
      A1L3W2, Q5TFZ3, Q6AI39, Q92514

    RNA

    1. XR_008487286.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AI39.2 GenPept UniProtKB/Swiss-Prot:Q6AI39

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