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    SMARCA4 SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4 [ Homo sapiens (human) ]

    Gene ID: 6597, updated on 2-Nov-2024

    Summary

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    Official Symbol
    SMARCA4provided by HGNC
    Official Full Name
    SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4provided by HGNC
    Primary source
    HGNC:HGNC:11100
    See related
    Ensembl:ENSG00000127616 MIM:603254; AllianceGenome:HGNC:11100
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BRG1; CSS4; SNF2; SWI2; MRD16; RTPS2; BAF190; OTSC12; SNF2L4; SNF2LB; hSNF2b; BAF190A; SNF2-beta
    Summary
    The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Mutations in this gene cause rhabdoid tumor predisposition syndrome type 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
    Expression
    Ubiquitous expression in testis (RPKM 21.8), brain (RPKM 14.5) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SMARCA4 in Genome Data Viewer
    Location:
    19p13.2
    Exon count:
    40
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (10961030..11062273)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (11088037..11189277)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (11071706..11172949)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene coactivator associated arginine methyltransferase 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:11037946-11038648 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:11038649-11039349 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10095 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10096 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:11046750-11047081 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:11048011-11048510 Neighboring gene Yip1 domain family member 2 Neighboring gene translocase of inner mitochondrial membrane 29 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10097 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10098 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10099 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14000 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14001 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:11087822-11088514 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:11120526-11121026 Neighboring gene RNA, 7SL, cytoplasmic 192, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:11138820-11139320 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14002 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14003 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14004 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14005 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:11167289-11167788 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:11200393-11200988 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:11200989-11201582 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr19:11202176-11203375 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr19:11205098-11206297 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:11212882-11213520 Neighboring gene LDLR antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:11215560-11216060 Neighboring gene low density lipoprotein receptor Neighboring gene microRNA 6886

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Loss of SMARCA4 Expression Is Both Sensitive and Specific for the Diagnosis of Small Cell Carcinoma of Ovary, Hypercalcemic Type. Conlon N, et al. Am J Surg Pathol, 2016 Mar. PMID 26645725, Free PMC Article
    2. The CRISPR/Cas system inhibited the pro-oncogenic effects of alternatively spliced fibronectin extra domain A via editing the genome in salivary adenoid cystic carcinoma cells. Wang HC, et al. Oral Dis, 2015 Jul. PMID 25684411
    3. Germline SMARCA4 mutations in patients with ovarian small cell carcinoma of hypercalcemic type. Moes-Sosnowska J, et al. Orphanet J Rare Dis, 2015 Mar 15. PMID 25886974, Free PMC Article
    4. Recent updates in thoracic SMARCA4-deficient undifferentiated tumor. Nambirajan A, et al. Semin Diagn Pathol, 2021 Sep. PMID 34147303
    5. SMARCA4 (BRG1) loss of expression is a useful marker for the diagnosis of ovarian small cell carcinoma of the hypercalcemic type (ovarian rhabdoid tumor): a comprehensive analysis of 116 rare gynecologic tumors, 9 soft tissue tumors, and 9 melanomas. Karanian-Philippe M, et al. Am J Surg Pathol, 2015 Sep. PMID 26135561

    See all (739) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SMARCA4-deficient undifferentiated gastric carcinoma: a case series and literature review.
      Title: SMARCA4-deficient undifferentiated gastric carcinoma: a case series and literature review.
    2. Association between Apo B, LDL-R and PCSK9 gene polymorphisms with coronary artery diseases in Egyptians.
      Title: Association between Apo B, LDL-R and PCSK9 gene polymorphisms with coronary artery diseases in Egyptians.
    3. SMARCA4 controls state plasticity in small cell lung cancer through regulation of neuroendocrine transcription factors and REST splicing.
      Title: SMARCA4 controls state plasticity in small cell lung cancer through regulation of neuroendocrine transcription factors and REST splicing.
    4. BRG1 promotes progression of B-cell acute lymphoblastic leukemia by disrupting PPP2R1A transcription.
      Title: BRG1 promotes progression of B-cell acute lymphoblastic leukemia by disrupting PPP2R1A transcription.
    5. BRG1 promotes liver cancer cell proliferation and metastasis by enhancing mitochondrial function and ATP5A1 synthesis through TOMM40.
      Title: BRG1 promotes liver cancer cell proliferation and metastasis by enhancing mitochondrial function and ATP5A1 synthesis through TOMM40.
    6. SMARCA4 oncogenic potential via IRAK1 enhancer to activate Gankyrin and AKR1B10 in liver cancer.
      Title: SMARCA4 oncogenic potential via IRAK1 enhancer to activate Gankyrin and AKR1B10 in liver cancer.
    7. SMARCA4 deficiency and mutations are frequent in large cell lung carcinoma and are prognostically significant.
      Title: SMARCA4 deficiency and mutations are frequent in large cell lung carcinoma and are prognostically significant.
    8. Gastric SMARCA4-deficient undifferentiated tumor (SMARCA4-UT): a clinicopathological analysis of four rare cases.
      Title: Gastric SMARCA4-deficient undifferentiated tumor (SMARCA4-UT): a clinicopathological analysis of four rare cases.
    9. ATP-dependent chromatin remodeller brahma related gene 1 promotes keratinocyte migration and modulates cell Signalling during wound healing in human skin.
      Title: ATP-dependent chromatin remodeller brahma related gene 1 promotes keratinocyte migration and modulates cell Signalling during wound healing in human skin.
    10. Rare SMARCA4-deficient thoracic tumor: Insights into molecular characterization and optimal therapeutics methods.
      Title: Rare SMARCA4-deficient thoracic tumor: Insights into molecular characterization and optimal therapeutics methods.
    Submit: New GeneRIF Correction See all GeneRIFs (379)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Intellectual disability, autosomal dominant 16
    MedGen: C3553249 OMIM: 614609 GeneReviews: Not available
    		Compare labs
    Rhabdoid tumor predisposition syndrome 2
    MedGen: C2750074 OMIM: 613325 GeneReviews: Not available
    		Compare labs

    Copy number response

    Description
    Copy number response
    Haploinsufficency

    Sufficient evidence for dosage pathogenicity (Last evaluated 2024-07-24)

    ClinGen Genome Curation PagePubMed
    Triplosensitivity

    No evidence available (Last evaluated 2024-07-24)

    ClinGen Genome Curation Page

    EBI GWAS Catalog

    Description
    Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants.
    EBI GWAS Catalog
    Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.
    EBI GWAS Catalog
    Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.
    EBI GWAS Catalog
    Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants.
    EBI GWAS Catalog

    Variation

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    See Variation Viewer (GRCh37.p13)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Most of the components of the SWI2/SNF2 chromatin remodeling complex (BRG1/BRM, BAF250, BAF180, BAF170, BAF155, BAF60a, BAF53A, actin and InI) except BRM, BAF155 and BAF57, are identified to interact with HIV-1 Tat in Jurkat cell PubMed
    tat HIV-1 Tat induces phosphorylation of BRG1 and BAF155 PubMed
    tat INI-1 and BRG-1 synergize with the p300 acetyltransferase to activate the HIV promoter; this synergism depends on the acetyltransferase activity of p300 and on HIV-1 Tat amino acids Lys(50) and Lys(51), suggesting a regulation of Tat by these proteins PubMed
    tat Acetylated HIV-1 Tat binds efficiently to BRG1 and BAF200 (component of PBAF complex) and weakly to BAF250 (component of BAF complex) PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ39786

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent activity, acting on DNA IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables ATP-dependent chromatin remodeler activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA polymerase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to RNA polymerase I core promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables Tat protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclear androgen receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    contributes_to nucleosomal DNA binding HDA PubMed 
    enables nucleosome array spacer activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables p53 binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription coactivator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transcription coactivator activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables transcription coregulator binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA polymerase I preinitiation complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling HDA PubMed 
    involved_in chromatin remodeling IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chromatin remodeling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin remodeling NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in heterochromatin formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of androgen receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cell differentiation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of cell growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neural retina development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in nucleosome disassembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation by host of viral transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of T cell differentiation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell differentiation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in positive regulation of double-strand break repair NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of glucose mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of miRNA transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of myoblast differentiation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of stem cell population maintenance NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of transcription of nucleolar large rRNA by RNA polymerase I IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of G0 to G1 transition NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of G1/S transition of mitotic cell cycle NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of mitotic metaphase/anaphase transition NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of nucleotide-excision repair NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in transcription initiation-coupled chromatin remodeling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of GBAF complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of RSC-type complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of SWI/SNF complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SWI/SNF complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of bBAF complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in chromatin HDA PubMed 
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromatin NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in extracellular space HDA PubMed 
    located_in fibrillar center IDA
    Inferred from Direct Assay
    more info
    		  
    located_in kinetochore NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in membrane HDA PubMed 
    part_of nBAF complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of nBAF complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of npBAF complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of npBAF complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of npBAF complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in nuclear matrix NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of protein-containing complex HDA PubMed 

    General protein information

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    Preferred Names
    transcription activator BRG1
    Names
    ATP-dependent helicase SMARCA4
    BRG1-associated factor 190A
    BRM/SWI2-related gene 1
    SNF2-like 4
    SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
    brahma protein-like 1
    global transcription activator homologous sequence
    homeotic gene regulator
    mitotic growth and transcription activator
    nuclear protein GRB1
    protein BRG-1
    protein brahma homolog 1
    sucrose nonfermenting-like 4

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011556.3 RefSeqGene

      Range
      5099..106342
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_878

    mRNA and Protein(s)

    1. NM_001128844.3 → NP_001122316.1  transcription activator BRG1 isoform B

      See identical proteins and their annotated locations for NP_001122316.1

      Status: REVIEWED

      Source sequence(s)
      AC006127, AC011442, AC011485
      Consensus CDS
      CCDS12253.1
      UniProtKB/Swiss-Prot
      B1A8Z4, B1A8Z5, B1A8Z6, B1A8Z7, E9PBR8, O95052, P51532, Q9HBD3
      UniProtKB/TrEMBL
      A7E2E1, B9EGQ8
      Related
      ENSP00000395654.1, ENST00000429416.8
      Conserved Domains (9) summary
      cd05516
      Location:1458 → 1564
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      smart00573
      Location:460 → 532
      HSA; domain in helicases and associated with SANT domains
      PLN03142
      Location:750 → 1232
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      COG1196
      Location:370 → 552
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam09606
      Location:42 → 222
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18062
      Location:731 → 981
      DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4
      pfam07533
      Location:612 → 654
      BRK; BRK domain
      pfam08880
      Location:171 → 205
      QLQ
      pfam14619
      Location:1323 → 1389
      SnAC; Snf2-ATP coupling, chromatin remodelling complex

    2. NM_001128845.2 → NP_001122317.1  transcription activator BRG1 isoform C

      See identical proteins and their annotated locations for NP_001122317.1

      Status: REVIEWED

      Source sequence(s)
      AC006127, AC011442, AC011485
      Consensus CDS
      CCDS45972.1
      UniProtKB/TrEMBL
      B9EGQ8
      Related
      ENSP00000496635.1, ENST00000643296.1
      Conserved Domains (9) summary
      cd05516
      Location:1428 → 1534
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      smart00592
      Location:612 → 656
      BRK; domain in transcription and CHROMO domain helicases
      smart00573
      Location:460 → 532
      HSA; domain in helicases and associated with SANT domains
      PLN03142
      Location:750 → 1232
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      COG1196
      Location:370 → 552
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam09606
      Location:42 → 222
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18062
      Location:731 → 981
      DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4
      pfam08880
      Location:171 → 205
      QLQ
      pfam14619
      Location:1289 → 1356
      SnAC; Snf2-ATP coupling, chromatin remodelling complex

    3. NM_001128846.2 → NP_001122318.1  transcription activator BRG1 isoform D

      See identical proteins and their annotated locations for NP_001122318.1

      Status: REVIEWED

      Source sequence(s)
      AC006127, AC011442, AC011485
      Consensus CDS
      CCDS45973.1
      UniProtKB/TrEMBL
      B9EGQ8
      Related
      ENSP00000464778.1, ENST00000589677.5
      Conserved Domains (9) summary
      cd05516
      Location:1428 → 1533
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      smart00592
      Location:612 → 656
      BRK; domain in transcription and CHROMO domain helicases
      smart00573
      Location:460 → 532
      HSA; domain in helicases and associated with SANT domains
      PLN03142
      Location:750 → 1232
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      COG1196
      Location:370 → 552
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam09606
      Location:42 → 222
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18062
      Location:731 → 981
      DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4
      pfam08880
      Location:171 → 205
      QLQ
      pfam14619
      Location:1289 → 1356
      SnAC; Snf2-ATP coupling, chromatin remodelling complex

    4. NM_001128847.4 → NP_001122319.1  transcription activator BRG1 isoform E

      See identical proteins and their annotated locations for NP_001122319.1

      Status: REVIEWED

      Source sequence(s)
      AC006127, AC011442, AC011485
      Consensus CDS
      CCDS54217.1
      UniProtKB/TrEMBL
      B9EGQ8
      Related
      ENSP00000494676.1, ENST00000647230.1
      Conserved Domains (9) summary
      cd05516
      Location:1425 → 1531
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      smart00573
      Location:460 → 532
      HSA; domain in helicases and associated with SANT domains
      PLN03142
      Location:750 → 1232
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      COG1196
      Location:370 → 552
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam09606
      Location:42 → 222
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18062
      Location:731 → 981
      DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4
      pfam07533
      Location:612 → 654
      BRK; BRK domain
      pfam08880
      Location:171 → 205
      QLQ
      pfam14619
      Location:1290 → 1356
      SnAC; Snf2-ATP coupling, chromatin remodelling complex

    5. NM_001128848.2 → NP_001122320.1  transcription activator BRG1 isoform F

      See identical proteins and their annotated locations for NP_001122320.1

      Status: REVIEWED

      Source sequence(s)
      AC006127, AC011442, AC011485
      Consensus CDS
      CCDS54218.1
      UniProtKB/TrEMBL
      B9EGQ8
      Conserved Domains (9) summary
      cd05516
      Location:1425 → 1530
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      smart00592
      Location:612 → 656
      BRK; domain in transcription and CHROMO domain helicases
      smart00573
      Location:460 → 532
      HSA; domain in helicases and associated with SANT domains
      PLN03142
      Location:750 → 1232
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      COG1196
      Location:370 → 552
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam09606
      Location:42 → 222
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18062
      Location:731 → 981
      DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4
      pfam08880
      Location:171 → 205
      QLQ
      pfam14619
      Location:1289 → 1356
      SnAC; Snf2-ATP coupling, chromatin remodelling complex

    6. NM_001128849.3 → NP_001122321.1  transcription activator BRG1 isoform A

      See identical proteins and their annotated locations for NP_001122321.1

      Status: REVIEWED

      Source sequence(s)
      AC006127, AC011442, AC011485
      UniProtKB/TrEMBL
      B9EGQ8, Q9HBD4
      Related
      ENSP00000518564.1, ENST00000711079.1
      Conserved Domains (9) summary
      cd05516
      Location:1490 → 1596
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      smart00573
      Location:460 → 532
      HSA; domain in helicases and associated with SANT domains
      PLN03142
      Location:750 → 1232
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      COG1196
      Location:370 → 552
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam09606
      Location:42 → 222
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18062
      Location:731 → 981
      DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4
      pfam07533
      Location:612 → 654
      BRK; BRK domain
      pfam08880
      Location:171 → 205
      QLQ
      pfam14619
      Location:1323 → 1389
      SnAC; Snf2-ATP coupling, chromatin remodelling complex

    7. NM_001374457.1 → NP_001361386.1  transcription activator BRG1 isoform E

      Status: REVIEWED

      Source sequence(s)
      AC006127, AC011442, AC011485
      Consensus CDS
      CCDS54217.1
      UniProtKB/TrEMBL
      B9EGQ8
      Related
      ENSP00000495536.1, ENST00000646484.1
      Conserved Domains (9) summary
      cd05516
      Location:1425 → 1531
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      smart00573
      Location:460 → 532
      HSA; domain in helicases and associated with SANT domains
      PLN03142
      Location:750 → 1232
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      COG1196
      Location:370 → 552
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam09606
      Location:42 → 222
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18062
      Location:731 → 981
      DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4
      pfam07533
      Location:612 → 654
      BRK; BRK domain
      pfam08880
      Location:171 → 205
      QLQ
      pfam14619
      Location:1290 → 1356
      SnAC; Snf2-ATP coupling, chromatin remodelling complex

    8. NM_001387283.1 → NP_001374212.1  transcription activator BRG1 isoform A

      Status: REVIEWED

      Source sequence(s)
      AC006127, AC011442, AC011485
      UniProtKB/TrEMBL
      B9EGQ8, Q9HBD4
      Related
      ENSP00000495368.1, ENST00000646693.2
      Conserved Domains (9) summary
      cd05516
      Location:1490 → 1596
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      smart00573
      Location:460 → 532
      HSA; domain in helicases and associated with SANT domains
      PLN03142
      Location:750 → 1232
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      COG1196
      Location:370 → 552
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam09606
      Location:42 → 222
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18062
      Location:731 → 981
      DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4
      pfam07533
      Location:612 → 654
      BRK; BRK domain
      pfam08880
      Location:171 → 205
      QLQ
      pfam14619
      Location:1323 → 1389
      SnAC; Snf2-ATP coupling, chromatin remodelling complex

    9. NM_001411150.1 → NP_001398079.1  transcription activator BRG1 isoform G

      Status: REVIEWED

      Source sequence(s)
      AC006127, AC011442, AC011485
      Consensus CDS
      CCDS92517.1
      UniProtKB/TrEMBL
      A0A2R8Y7S2
      Related
      ENSP00000494353.1, ENST00000642726.1

    10. NM_003072.5 → NP_003063.2  transcription activator BRG1 isoform B

      See identical proteins and their annotated locations for NP_003063.2

      Status: REVIEWED

      Source sequence(s)
      AC006127, AC011442, AC011485
      Consensus CDS
      CCDS12253.1
      UniProtKB/Swiss-Prot
      B1A8Z4, B1A8Z5, B1A8Z6, B1A8Z7, E9PBR8, O95052, P51532, Q9HBD3
      UniProtKB/TrEMBL
      A7E2E1, B9EGQ8
      Related
      ENSP00000343896.4, ENST00000344626.10
      Conserved Domains (9) summary
      cd05516
      Location:1458 → 1564
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      smart00573
      Location:460 → 532
      HSA; domain in helicases and associated with SANT domains
      PLN03142
      Location:750 → 1232
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      COG1196
      Location:370 → 552
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam09606
      Location:42 → 222
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18062
      Location:731 → 981
      DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4
      pfam07533
      Location:612 → 654
      BRK; BRK domain
      pfam08880
      Location:171 → 205
      QLQ
      pfam14619
      Location:1323 → 1389
      SnAC; Snf2-ATP coupling, chromatin remodelling complex

    RNA

    1. NR_164683.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC006127, AC011442, AC011485

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      10961030..11062273
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011528198.2 → XP_011526500.1  transcription activator BRG1 isoform X1

      See identical proteins and their annotated locations for XP_011526500.1

      UniProtKB/TrEMBL
      B9EGQ8, Q9HBD4
      Conserved Domains (9) summary
      cd05516
      Location:1490 → 1596
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      smart00573
      Location:460 → 532
      HSA; domain in helicases and associated with SANT domains
      PLN03142
      Location:750 → 1232
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      COG1196
      Location:370 → 552
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam09606
      Location:42 → 222
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18062
      Location:731 → 981
      DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4
      pfam07533
      Location:612 → 654
      BRK; BRK domain
      pfam08880
      Location:171 → 205
      QLQ
      pfam14619
      Location:1323 → 1389
      SnAC; Snf2-ATP coupling, chromatin remodelling complex

    2. XM_047439249.1 → XP_047295205.1  transcription activator BRG1 isoform X6

      Conserved Domains (9) summary
      cd05516
      Location:1425 → 1530
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      smart00592
      Location:612 → 656
      BRK; domain in transcription and CHROMO domain helicases
      smart00573
      Location:460 → 532
      HSA; domain in helicases and associated with SANT domains
      PLN03142
      Location:750 → 1232
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      COG1196
      Location:370 → 552
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam09606
      Location:42 → 222
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18062
      Location:731 → 981
      DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4
      pfam08880
      Location:171 → 205
      QLQ
      pfam14619
      Location:1289 → 1356
      SnAC; Snf2-ATP coupling, chromatin remodelling complex

    3. XM_024451658.2 → XP_024307426.1  transcription activator BRG1 isoform X1

      UniProtKB/TrEMBL
      B9EGQ8, Q9HBD4
      Conserved Domains (9) summary
      cd05516
      Location:1490 → 1596
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      smart00573
      Location:460 → 532
      HSA; domain in helicases and associated with SANT domains
      PLN03142
      Location:750 → 1232
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      COG1196
      Location:370 → 552
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam09606
      Location:42 → 222
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18062
      Location:731 → 981
      DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4
      pfam07533
      Location:612 → 654
      BRK; BRK domain
      pfam08880
      Location:171 → 205
      QLQ
      pfam14619
      Location:1323 → 1389
      SnAC; Snf2-ATP coupling, chromatin remodelling complex

    4. XM_047439247.1 → XP_047295203.1  transcription activator BRG1 isoform X5

      Related
      ENSP00000494772.1, ENST00000646510.1

    5. XM_024451661.2 → XP_024307429.1  transcription activator BRG1 isoform X3

      UniProtKB/TrEMBL
      A0A2R8Y7S2, B9EGQ8
      Related
      ENSP00000496498.1, ENST00000642628.1
      Conserved Domains (9) summary
      cd05516
      Location:1457 → 1563
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      smart00573
      Location:460 → 532
      HSA; domain in helicases and associated with SANT domains
      PLN03142
      Location:750 → 1232
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      COG1196
      Location:370 → 552
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam09606
      Location:42 → 222
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18062
      Location:731 → 981
      DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4
      pfam07533
      Location:612 → 654
      BRK; BRK domain
      pfam08880
      Location:171 → 205
      QLQ
      pfam14619
      Location:1290 → 1356
      SnAC; Snf2-ATP coupling, chromatin remodelling complex

    6. XM_024451663.2 → XP_024307431.1  transcription activator BRG1 isoform X4

      UniProtKB/TrEMBL
      B9EGQ8
      Conserved Domains (8) summary
      cd05516
      Location:1457 → 1562
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      smart00592
      Location:612 → 656
      BRK; domain in transcription and CHROMO domain helicases
      smart00573
      Location:460 → 532
      HSA; domain in helicases and associated with SANT domains
      pfam08880
      Location:171 → 205
      QLQ; QLQ
      pfam09606
      Location:42 → 222
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam14619
      Location:1289 → 1356
      SnAC; Snf2-ATP coupling, chromatin remodelling complex
      cl25732
      Location:370 → 552
      SMC_N; RecF/RecN/SMC N terminal domain
      cl26465
      Location:750 → 1232
      SNF2_N; SNF2 family N-terminal domain

    7. XM_024451667.2 → XP_024307435.1  transcription activator BRG1 isoform X6

      UniProtKB/TrEMBL
      B9EGQ8
      Conserved Domains (9) summary
      cd05516
      Location:1425 → 1530
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      smart00592
      Location:612 → 656
      BRK; domain in transcription and CHROMO domain helicases
      smart00573
      Location:460 → 532
      HSA; domain in helicases and associated with SANT domains
      PLN03142
      Location:750 → 1232
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      COG1196
      Location:370 → 552
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam09606
      Location:42 → 222
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18062
      Location:731 → 981
      DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4
      pfam08880
      Location:171 → 205
      QLQ
      pfam14619
      Location:1289 → 1356
      SnAC; Snf2-ATP coupling, chromatin remodelling complex

    8. XM_047439244.1 → XP_047295200.1  transcription activator BRG1 isoform X2

      UniProtKB/Swiss-Prot
      B1A8Z4, B1A8Z5, B1A8Z6, B1A8Z7, E9PBR8, O95052, P51532, Q9HBD3
      UniProtKB/TrEMBL
      A7E2E1
      Related
      ENSP00000515855.1, ENST00000704344.1

    9. XM_047439246.1 → XP_047295202.1  transcription activator BRG1 isoform X4

    10. XM_047439250.1 → XP_047295206.1  transcription activator BRG1 isoform X6

      Related
      ENSP00000494463.1, ENST00000645460.1
      Conserved Domains (9) summary
      cd05516
      Location:1425 → 1530
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      smart00592
      Location:612 → 656
      BRK; domain in transcription and CHROMO domain helicases
      smart00573
      Location:460 → 532
      HSA; domain in helicases and associated with SANT domains
      PLN03142
      Location:750 → 1232
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      COG1196
      Location:370 → 552
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam09606
      Location:42 → 222
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18062
      Location:731 → 981
      DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4
      pfam08880
      Location:171 → 205
      QLQ
      pfam14619
      Location:1289 → 1356
      SnAC; Snf2-ATP coupling, chromatin remodelling complex

    11. XM_047439243.1 → XP_047295199.1  transcription activator BRG1 isoform X1

      UniProtKB/TrEMBL
      Q9HBD4

    12. XM_006722846.3 → XP_006722909.1  transcription activator BRG1 isoform X1

      See identical proteins and their annotated locations for XP_006722909.1

      UniProtKB/TrEMBL
      B9EGQ8, Q9HBD4
      Conserved Domains (9) summary
      cd05516
      Location:1490 → 1596
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      smart00573
      Location:460 → 532
      HSA; domain in helicases and associated with SANT domains
      PLN03142
      Location:750 → 1232
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      COG1196
      Location:370 → 552
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam09606
      Location:42 → 222
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18062
      Location:731 → 981
      DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4
      pfam07533
      Location:612 → 654
      BRK; BRK domain
      pfam08880
      Location:171 → 205
      QLQ
      pfam14619
      Location:1323 → 1389
      SnAC; Snf2-ATP coupling, chromatin remodelling complex

    13. XM_047439248.1 → XP_047295204.1  transcription activator BRG1 isoform X5

      Related
      ENSP00000466963.1, ENST00000590574.6

    14. XM_047439251.1 → XP_047295207.1  transcription activator BRG1 isoform X6

      Conserved Domains (9) summary
      cd05516
      Location:1425 → 1530
      Bromo_SNF2L2; Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone ...
      smart00592
      Location:612 → 656
      BRK; domain in transcription and CHROMO domain helicases
      smart00573
      Location:460 → 532
      HSA; domain in helicases and associated with SANT domains
      PLN03142
      Location:750 → 1232
      PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
      COG1196
      Location:370 → 552
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam09606
      Location:42 → 222
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd18062
      Location:731 → 981
      DEXHc_SMARCA4; DEXH-box helicase domain of SMARCA4
      pfam08880
      Location:171 → 205
      QLQ
      pfam14619
      Location:1289 → 1356
      SnAC; Snf2-ATP coupling, chromatin remodelling complex

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      11088037..11189277
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321813.1 → XP_054177788.1  transcription activator BRG1 isoform X1

      UniProtKB/TrEMBL
      Q9HBD4

    2. XM_054321823.1 → XP_054177798.1  transcription activator BRG1 isoform X6

    3. XM_054321814.1 → XP_054177789.1  transcription activator BRG1 isoform X1

      UniProtKB/TrEMBL
      Q9HBD4

    4. XM_054321821.1 → XP_054177796.1  transcription activator BRG1 isoform X5

    5. XM_054321818.1 → XP_054177793.1  transcription activator BRG1 isoform X3

      UniProtKB/TrEMBL
      A0A2R8Y7S2

    6. XM_054321819.1 → XP_054177794.1  transcription activator BRG1 isoform X4

    7. XM_054321824.1 → XP_054177799.1  transcription activator BRG1 isoform X6

    8. XM_054321817.1 → XP_054177792.1  transcription activator BRG1 isoform X2

      UniProtKB/Swiss-Prot
      B1A8Z4, B1A8Z5, B1A8Z6, B1A8Z7, E9PBR8, O95052, P51532, Q9HBD3
      UniProtKB/TrEMBL
      A7E2E1

    9. XM_054321820.1 → XP_054177795.1  transcription activator BRG1 isoform X4

    10. XM_054321825.1 → XP_054177800.1  transcription activator BRG1 isoform X6

    11. XM_054321816.1 → XP_054177791.1  transcription activator BRG1 isoform X1

      UniProtKB/TrEMBL
      Q9HBD4

    12. XM_054321815.1 → XP_054177790.1  transcription activator BRG1 isoform X1

      UniProtKB/TrEMBL
      Q9HBD4

    13. XM_054321826.1 → XP_054177801.1  transcription activator BRG1 isoform X6

    14. XM_054321822.1 → XP_054177797.1  transcription activator BRG1 isoform X5

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P51532.2 GenPept UniProtKB/Swiss-Prot:P51532

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