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    DUSP19 dual specificity phosphatase 19 [ Homo sapiens (human) ]

    Gene ID: 142679, updated on 28-Oct-2024

    Summary

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    Official Symbol
    DUSP19provided by HGNC
    Official Full Name
    dual specificity phosphatase 19provided by HGNC
    Primary source
    HGNC:HGNC:18894
    See related
    Ensembl:ENSG00000162999 MIM:611437; AllianceGenome:HGNC:18894
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SKRP1; DUSP17; LMWDSP3; TS-DSP1
    Summary
    Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP19 contains a variation of the consensus DUSP C-terminal catalytic domain, with the last serine residue replaced by alanine, and lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    mouse all
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    Genomic context

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    See DUSP19 in Genome Data Viewer
    Location:
    2q32.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (183078747..183100008)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (183567739..183589000)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (183943475..183964736)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA77 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:183934151-183934652 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr2:183935853-183936421 Neighboring gene keratin 8 pseudogene 10 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16838 Neighboring gene uncharacterized LOC124907917 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:183989221-183989989 Neighboring gene nucleoporin 35 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:184037030-184037616 Neighboring gene uncharacterized LOC124906103

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. DUSP19 mediates spinal cord injury-induced apoptosis and inflammation in mouse primary microglia cells via the NF-kB signaling pathway. Xie XK, et al. Neurol Res, 2020 Jan. PMID 31813339
    2. Crystal structure of a novel mitogen-activated protein kinase phosphatase, SKRP1. Wei CH, et al. Proteins, 2011 Nov. PMID 21989941
    3. Molecular cloning and characterization of a novel human protein phosphatase, LMW-DSP3. Cheng H, et al. Int J Biochem Cell Biol, 2003 Feb. PMID 12479873
    4. Circ_HIPK3 alleviates CoCl(2)-induced apoptotic injury in neuronal cells by depending on the regulation of the miR-222-3p/DUSP19 axis. Liu Y, et al. Biochem Biophys Res Commun, 2021 May 14. PMID 33770577
    5. PTEN regulates invasiveness in pancreatic neuroendocrine tumors through DUSP19-mediated VEGFR3 dephosphorylation. Chang TM, et al. J Biomed Sci, 2022 Nov 6. PMID 36336681, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PTEN regulates invasiveness in pancreatic neuroendocrine tumors through DUSP19-mediated VEGFR3 dephosphorylation.
      Title: PTEN regulates invasiveness in pancreatic neuroendocrine tumors through DUSP19-mediated VEGFR3 dephosphorylation.
    2. Circ_HIPK3 alleviates CoCl2-induced apoptotic injury in neuronal cells by depending on the regulation of the miR-222-3p/DUSP19 axis.
      Title: Circ_HIPK3 alleviates CoCl(2)-induced apoptotic injury in neuronal cells by depending on the regulation of the miR-222-3p/DUSP19 axis.
    3. DUSP19 mediates spinal cord injury-induced apoptosis and inflammation in mouse primary microglia cells via the NF-kB signaling pathway.
      Title: DUSP19 mediates spinal cord injury-induced apoptosis and inflammation in mouse primary microglia cells via the NF-kB signaling pathway.
    4. the activity of JNK stimulated by leptin was suppressed by DUSP19 overexpression.
      Title: DUSP19, a downstream effector of leptin, inhibits chondrocyte apoptosis via dephosphorylating JNK during osteoarthritis pathogenesis.
    5. crystal structure of SKRP1 (C150S) has been determined and refined at 1.26 A resolution (Table I). The structure reveals 142 residues (residues 65-206) of SKRP1 and three ions (two sulfates and one phosphate) at the catalytic site
      Title: Crystal structure of a novel mitogen-activated protein kinase phosphatase, SKRP1.
    6. LMW-DSP3 was expressed in the heart, lung, liver, and pancreas, and the expression level in the pancreas was highest. The LMW-DSP3 gene was located in human chromosome 2q32, and consisted of five exons spanning 21kb of human genomic DNA[LMW-DSP3]
      Title: Molecular cloning and characterization of a novel human protein phosphatase, LMW-DSP3.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC138210

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables JUN kinase phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables MAP-kinase scaffold activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables mitogen-activated protein kinase kinase kinase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein kinase inhibitor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine/serine/threonine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of JNK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of JUN kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of JNK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of JUN kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of MAPK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of JNK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    dual specificity protein phosphatase 19
    Names
    SAPK pathway-regulating phosphatase 1
    dual specificity phosphatase TS-DSP1
    low molecular weight dual specificity phosphatase 3
    protein phosphatase SKRP1
    stress-activated protein kinase pathway-regulating phosphatase 1
    NP_001135786.1
    NP_001308448.1
    NP_543152.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001142314.2 → NP_001135786.1  dual specificity protein phosphatase 19 isoform 2

      See identical proteins and their annotated locations for NP_001135786.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the mid coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
      Source sequence(s)
      AB063187, AC064871, BC035000
      Consensus CDS
      CCDS46469.1
      UniProtKB/Swiss-Prot
      Q8WTR2
      Related
      ENSP00000343905.6, ENST00000342619.10
      Conserved Domains (1) summary
      cl28904
      Location:65 → 150
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    2. NM_001321519.2 → NP_001308448.1  dual specificity protein phosphatase 19 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AB063186, AC064871, BX647818
      UniProtKB/Swiss-Prot
      Q8WTR2
      Conserved Domains (1) summary
      cl28904
      Location:65 → 96
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    3. NM_080876.4 → NP_543152.1  dual specificity protein phosphatase 19 isoform 1

      See identical proteins and their annotated locations for NP_543152.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AB063186, AC064871, BC035000
      Consensus CDS
      CCDS2289.1
      UniProtKB/Swiss-Prot
      B2RA79, Q547H4, Q8WTR2, Q8WYN4
      Related
      ENSP00000346160.4, ENST00000354221.5
      Conserved Domains (1) summary
      cd14523
      Location:65 → 201
      DSP_DUSP19; dual specificity phosphatase domain of dual specificity protein phosphatase 19

    RNA

    1. NR_135688.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AB063186, AC064871, BC143337

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      183078747..183100008
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      183567739..183589000
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8WTR2.1 GenPept UniProtKB/Swiss-Prot:Q8WTR2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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