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    RNR5 RNA, ribosomal 45S cluster 5 [ Homo sapiens (human) ]

    Gene ID: 6056, updated on 17-Aug-2024

    Summary

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    Official Symbol
    RNR5provided by HGNC
    Official Full Name
    RNA, ribosomal 45S cluster 5provided by HGNC
    Primary source
    HGNC:HGNC:10086
    See related
    MIM:180454
    Gene type
    other
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    45S ribosomal DNA (rDNA) arrays, or clusters, are present on human chromosomes 13, 14, 15, 21 and 22, designated RNR1 through RNR5, respectively. Each cluster consists of multiple 45S rDNA repeat units that vary in number among individuals and chromosomes, with total diploid copy number estimates ranging from 60 to >800 repeat units in a human genome. The 45S rDNA repeat unit encodes a 45S rRNA precursor, transcribed by RNA polymerase I, which is processed to form the 18S, 5.8S and 28S rRNAs. Gene and RefSeq, in collaboration with HGNC, currently describe one 45S rDNA cluster, and one set of 45S precursor and product rRNAs, for each of the five human chromosomes to which these loci are localized. This gene represents the 45S ribosomal DNA cluster on chromosome 22. [provided by RefSeq, Feb 2017]
    Annotation information
    not in current annotation release
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    Genomic context

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    Location:
    22p12

    Bibliography

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    Related articles in PubMed

    1. Human rDNA: evolutionary patterns within the genes and tandem arrays derived from multiple chromosomes. Gonzalez IL, et al. Genomics, 2001 May 1. PMID 11350117
    2. Nucleolar organizer regions: genomic 'dark matter' requiring illumination. McStay B. Genes Dev, 2016 Jul 15. PMID 27474438, Free PMC Article
    3. The human 18S ribosomal RNA gene: evolution and stability. Gonzalez IL, et al. Am J Hum Genet, 1986 Apr. PMID 2422931, Free PMC Article
    4. A novel strategy for constructing clustered point mutations. Haltiner M, et al. Nucleic Acids Res, 1985 Feb 11. PMID 2987803, Free PMC Article
    5. Evolutionary changes of sequences and factors that direct transcription termination of human and mouse ribsomal genes. Bartsch I, et al. Mol Cell Biol, 1987 Jul. PMID 3649563, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Other Names

    • 45S rDNA cluster 5
    • RNA, ribosomal 5
    • RNA, ribosomal cluster 5
    • Ribosomal RNA-5

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