| Interaction of E2F3a and CASP8AP2 Regulates Histone Expression and Chemosensitivity of Leukemic Cells. | Interaction of E2F3a and CASP8AP2 Regulates Histone Expression and Chemosensitivity of Leukemic Cells.
Jin FF, Wang CJ, Cui L, Liu FF, Wang KL, Li WJ, Li ZG., Free PMC Article | 03/27/2023 |
| CRISPRi screening identifies CASP8AP2 as an essential viability factor in lung cancer controlling tumor cell death via the AP-1 pathway. | CRISPRi screening identifies CASP8AP2 as an essential viability factor in lung cancer controlling tumor cell death via the AP-1 pathway.
Myacheva K, Walsh A, Riester M, Pelos G, Carl J, Diederichs S. | 11/19/2022 |
| Interaction between CASP8AP2 and ZEB2-CtBP2 Regulates the Expression of LEF1. | Interaction between CASP8AP2 and ZEB2-CtBP2 Regulates the Expression of LEF1.
Wang CJ, Jia MZ, Deng LP, Li WJ, Zhang Q, Zhang TJ, Li SY, Cui L, Li ZG. | 09/3/2022 |
| Knockout of the caspase 8-associated protein 2 gene improves recombinant protein expression in HEK293 cells through up-regulation of the cyclin-dependent kinase inhibitor 2A gene. | Knockout of the caspase 8-associated protein 2 gene improves recombinant protein expression in HEK293 cells through up-regulation of the cyclin-dependent kinase inhibitor 2A gene.
Abaandou L, Sharma AK, Shiloach J., Free PMC Article | 11/27/2021 |
| Low expression of CTBP2 and CASP8AP2 predicts risk of relapse in childhood B-cell precursor acute lymphoblastic leukemia: a retrospective cohort study. | Low expression of CTBP2 and CASP8AP2 predicts risk of relapse in childhood B-cell precursor acute lymphoblastic leukemia: a retrospective cohort study.
Cui L, Gao C, Wang CJ, Liu SG, Wu MY, Zhang RD, Li ZG. | 02/20/2021 |
| Structural Analysis of the SANT/Myb Domain of FLASH and YARP Proteins and Their Complex with the C-Terminal Fragment of NPAT by NMR Spectroscopy and Computer Simulations. | Structural Analysis of the SANT/Myb Domain of FLASH and YARP Proteins and Their Complex with the C-Terminal Fragment of NPAT by NMR Spectroscopy and Computer Simulations.
Bucholc K, Skrajna A, Adamska K, Yang XC, Krajewski K, Poznański J, Dadlez M, Domiński Z, Zhukov I., Free PMC Article | 02/20/2021 |
| Here, we assembled core U7 snRNP bound to FLASH from recombinant components and analyzed its appearance by electron microscopy and ability to support histone pre-mRNA processing in the presence of polyadenylation factors from nuclear extracts | Composition and processing activity of a semi-recombinant holo U7 snRNP.
Bucholc K, Aik WS, Yang XC, Wang K, Zhou ZH, Dadlez M, Marzluff WF, Tong L, Dominski Z., Free PMC Article | 03/21/2020 |
| FLASH plays two roles in 3' end processing of histone pre-mRNAs: It interacts with Lsm11 to form a docking platform for the polyadenylation factors, and it cooperates with SLBP to recruit U7 snRNP to histone pre-mRNA. | U7 snRNP is recruited to histone pre-mRNA in a FLASH-dependent manner by two separate regions of the stem-loop binding protein.
Skrajna A, Yang XC, Bucholc K, Zhang J, Hall TMT, Dadlez M, Marzluff WF, Dominski Z., Free PMC Article | 09/16/2017 |
| FLASH is required for embryogenesis, but not for cell proliferation or differentiation in embryonic stem cells. | FLASH/casp8ap2 is indispensable for early embryogenesis but dispensable for proliferation and differentiation of ES cells.
Minamida Y, Someda M, Yonehara S., Free PMC Article | 11/21/2015 |
| Our results indicate that the APAF1, BAX, and FLASH genes not only harbor frameshift mutations but also demonstrate mutational ITH, which together might play a role in the tumorigenesis of CRC with MSI-H by affecting the apoptosis of cancer cells. | Regional Bias of Intratumoral Genetic Heterogeneity of Apoptosis-Related Genes BAX, APAF1, and FLASH in Colon Cancers with High Microsatellite Instability.
Choi MR, Gwak M, Yoo NJ, Lee SH. | 08/15/2015 |
| High-quality solution NMR structures of three homeodomains from human proteins ALX4, ZHX1 and CASP8AP2 were solved. | Solution NMR structures of homeodomains from human proteins ALX4, ZHX1, and CASP8AP2 contribute to the structural coverage of the Human Cancer Protein Interaction Network.
Xu X, Pulavarti SV, Eletsky A, Huang YJ, Acton TB, Xiao R, Everett JK, Montelione GT, Szyperski T., Free PMC Article | 07/25/2015 |
| the predictive values regarding low expressions of H2AFZ and CASP8AP2 and high white blood cell count suggest that these features could help to identify more accurately patients at greater risk of relapse. | Significance of CASP8AP2 and H2AFZ expression in survival and risk of relapse in children with acute lymphoblastic leukemia.
Juárez-Velázquez R, Reyes-León A, Salas-Labadía C, Rivera-Luna R, Velasco-Hidalgo L, López-Hernández G, López-Santiago N, Paredes-Aguilera R, Domínguez-López A, Bernáldez R, Pérez-Vera P. | 06/20/2015 |
| ARS2 and CASP8AP2 expressions can precisely predict high-risk of relapse and ALL prognosis. | Low expressions of ARS2 and CASP8AP2 predict relapse and poor prognosis in pediatric acute lymphoblastic leukemia patients treated on China CCLG-ALL 2008 protocol.
Cui L, Gao C, Zhang RD, Jiao Y, Li WJ, Zhao XX, Liu SG, Yue ZX, Zheng HY, Deng GR, Wu MY, Li ZG, Jia HT. | 03/28/2015 |
| The conserved C-terminal domain shared by FLASH, YARP, and Mute recognizes the C-terminal sequence of NPAT orthologues, thus acting as a signal targeting proteins to histone locus bodies. | A conserved interaction that is essential for the biogenesis of histone locus bodies.
Yang XC, Sabath I, Kunduru L, van Wijnen AJ, Marzluff WF, Dominski Z., Free PMC Article | 03/7/2015 |
| Data suggest that SUMO targets FLASH for proteasome-dependent degradation, which is associated with recruitment of FLASH to PML bodies. | SUMO regulates proteasome-dependent degradation of FLASH/Casp8AP2.
Vennemann A, Hofmann TG., Free PMC Article | 02/8/2014 |
| Hypermethylation of two CpG sites upstream of CASP8AP2 promoter influences gene expression and treatment outcome in childhood acute lymphoblastic leukemia. | Hypermethylation of two CpG sites upstream of CASP8AP2 promoter influences gene expression and treatment outcome in childhood acute lymphoblastic leukemia.
Li ZG, Jiao Y, Li WJ, Deng GR, Cui L, Gao C, Zhao XX, Wu MY, Jia HT. | 11/16/2013 |
| FLASH/Lsm11 complex bind a unique combination of polyadenylation factors | A complex containing the CPSF73 endonuclease and other polyadenylation factors associates with U7 snRNP and is recruited to histone pre-mRNA for 3'-end processing.
Yang XC, Sabath I, Dębski J, Kaus-Drobek M, Dadlez M, Marzluff WF, Dominski Z., Free PMC Article | 04/27/2013 |
| These data demonstrate that methylation within the Casp8AP2 promoter correlates with the development of drug resistance and might serve as a biomarker and treatment target for drug resistance in cancer cells. | Targeted Casp8AP2 methylation increases drug resistance in mesenchymal stem cells and cancer cells.
Lee KD, Pai MY, Hsu CC, Chen CC, Chen YL, Chu PY, Lee CH, Chen LT, Chang JY, Huang TH, Hsiao SH, Leu YW. | 09/8/2012 |
| FLASH knockdown in HT1080 mutant cells defective in p53 did not significantly accelerate Fas mediated apoptosis indicating that the effect was dependent on functional p53. | FLASH knockdown sensitizes cells to Fas-mediated apoptosis via down-regulation of the anti-apoptotic proteins, MCL-1 and Cflip short.
Chen S, Evans HG, Evans DR., Free PMC Article | 08/25/2012 |
| This study further defines the role CASP8AP2/FLASH plays in the regulating expression of the replication-dependent histones and shows that its LOF results in broad and reproducible effects on the transcriptome of colorectal cancer cells | Systems-wide RNAi analysis of CASP8AP2/FLASH shows transcriptional deregulation of the replication-dependent histone genes and extensive effects on the transcriptome of colorectal cancer cells.
Hummon AB, Pitt JJ, Camps J, Emons G, Skube SB, Huppi K, Jones TL, Beissbarth T, Kramer F, Grade M, Difilippantonio MJ, Ried T, Caplen NJ., Free PMC Article | 06/16/2012 |
| Data show that show that the transcription factor p73 binds to Flice-Associated Huge Protein (FLASH) and is part of the complex that regulates histone gene transcription. | FLASH is essential during early embryogenesis and cooperates with p73 to regulate histone gene transcription.
De Cola A, Bongiorno-Borbone L, Bianchi E, Barcaroli D, Carletti E, Knight RA, Di Ilio C, Melino G, Sette C, De Laurenzi V. | 03/31/2012 |
| CASP8AP2 is a promising prognostic indicator in pediatric acute lymphoblastic leukemia. | CASP8AP2 is a promising prognostic indicator in pediatric acute lymphoblastic leukemia.
Jiao Y, Cui L, Gao C, Li W, Zhao X, Liu S, Wu M, Deng G, Li Z. | 02/4/2012 |
| PIAS1 is a common partner for two cancer-related nuclear factors, c-Myb and FLASH. | PIAS1 interacts with FLASH and enhances its co-activation of c-Myb.
Alm-Kristiansen AH, Lorenzo PI, Molværsmyr AK, Matre V, Ledsaak M, Sæther T, Gabrielsen OS., Free PMC Article | 06/18/2011 |
| Critical residues in human FLASH and Lsm11 that are involved in the interaction between these two proteins, are identified. | FLASH is required for the endonucleolytic cleavage of histone pre-mRNAs but is dispensable for the 5' exonucleolytic degradation of the downstream cleavage product.
Yang XC, Xu B, Sabath I, Kunduru L, Burch BD, Marzluff WF, Dominski Z., Free PMC Article | 05/21/2011 |
| investigated the expression of three apoptosis related genes, BCL2L13, CASP8AP2, and Livin, as well as their prognostic significance, in a retrospective study of 90 pediatric ALL patients diagnosed between 1996 and 2007 in Taiwan | Expression and prognostic significance of the apoptotic genes BCL2L13, Livin, and CASP8AP2 in childhood acute lymphoblastic leukemia.
Yang YL, Lin SR, Chen JS, Lin SW, Yu SL, Chen HY, Yen CT, Lin CY, Lin JF, Lin KH, Jou ST, Hu CY, Chang SK, Lu MY, Chang HH, Chang WH, Lin KS, Lin DT. | 02/22/2010 |