| USP3: Key deubiquitylation enzyme in human diseases. | USP3: Key deubiquitylation enzyme in human diseases.
Zhang H, Liu W, Wu Y, Chen C., Free PMC Article | 07/15/2024 |
| USP3 inhibition is Active Against Chemo-resistant Hepatocellular Carcinoma Anchorage-independent Growth via Suppressing Wnt/beta-catenin. | USP3 inhibition is Active Against Chemo-resistant Hepatocellular Carcinoma Anchorage-independent Growth via Suppressing Wnt/β-catenin.
Xu J, Gui GSW, Yang C, Zhu S, Chen Z, Ma SLB, Yang C, Bu CRL, Zhu Y, Xu W. | 06/27/2024 |
| USP3 promotes cisplatin resistance in non-small cell lung cancer cells by suppressing ACOT7-regulated ferroptosis. | USP3 promotes cisplatin resistance in non-small cell lung cancer cells by suppressing ACOT7-regulated ferroptosis.
Tao R, Liu Z, Zhang Z, Zhang Z. | 05/13/2024 |
| USP3 promotes osteosarcoma progression via deubiquitinating EPHA2 and activating the PI3K/AKT signaling pathway. | USP3 promotes osteosarcoma progression via deubiquitinating EPHA2 and activating the PI3K/AKT signaling pathway.
Li A, Wang S, Nie J, Xiao S, Xie X, Zhang Y, Tong W, Yao G, Liu N, Dan F, Shu Z, Liu J, Liu Z, Yang F., Free PMC Article | 03/29/2024 |
| CRISPR/Cas9-based genome-wide screening of the deubiquitinase subfamily identifies USP3 as a protein stabilizer of REST blocking neuronal differentiation and promotes neuroblastoma tumorigenesis. | CRISPR/Cas9-based genome-wide screening of the deubiquitinase subfamily identifies USP3 as a protein stabilizer of REST blocking neuronal differentiation and promotes neuroblastoma tumorigenesis.
Karapurkar JK, Kim MS, Colaco JC, Suresh B, Sarodaya N, Kim DH, Park CH, Hong SH, Kim KS, Ramakrishna S., Free PMC Article | 06/2/2023 |
| Deubiquitinase ubiquitin-specific protease 3 (USP3) inhibits HIV-1 replication via promoting APOBEC3G (A3G) expression in both enzyme activity-dependent and -independent manners. | Deubiquitinase ubiquitin-specific protease 3 (USP3) inhibits HIV-1 replication via promoting APOBEC3G (A3G) expression in both enzyme activity-dependent and -independent manners.
Zhao S, Zheng B, Wang L, Cui W, Jiang C, Li Z, Gao W, Zhang W., Free PMC Article | 02/11/2023 |
| USP3 promotes gastric cancer progression and metastasis by deubiquitination-dependent COL9A3/COL6A5 stabilisation. | USP3 promotes gastric cancer progression and metastasis by deubiquitination-dependent COL9A3/COL6A5 stabilisation.
Wu X, Wang H, Zhu D, Chai Y, Wang J, Dai W, Xiao Y, Tang W, Li J, Hong L, Pei M, Zhang J, Lin Z, Wang J, Li A, Liu S., Free PMC Article | 03/26/2022 |
| MicroRNA-146-5p Promotes Pulmonary Artery Endothelial Cell Proliferation under Hypoxic Conditions through Regulating USP3. | MicroRNA-146-5p Promotes Pulmonary Artery Endothelial Cell Proliferation under Hypoxic Conditions through Regulating USP3.
Zhang W, Qi Y, Wu B., Free PMC Article | 03/19/2022 |
| Protein deubiquitylase USP3 stabilizes Aurora A to promote proliferation and metastasis of esophageal squamous cell carcinoma. | Protein deubiquitylase USP3 stabilizes Aurora A to promote proliferation and metastasis of esophageal squamous cell carcinoma.
Shi K, Zhang JZ, Yang L, Li NN, Yue Y, Du XH, Zhang XZ, Lu YC, Guo D., Free PMC Article | 02/26/2022 |
| Genome-scale screening of deubiquitinase subfamily identifies USP3 as a stabilizer of Cdc25A regulating cell cycle in cancer. | Genome-scale screening of deubiquitinase subfamily identifies USP3 as a stabilizer of Cdc25A regulating cell cycle in cancer.
Das S, Chandrasekaran AP, Suresh B, Haq S, Kang JH, Lee SJ, Kim J, Kim J, Lee S, Kim HH, Kim KS, Ramakrishna S., Free PMC Article | 11/22/2021 |
| Ubiquitin-Specific Protease 3 Deubiquitinates and Stabilizes Oct4 Protein in Human Embryonic Stem Cells. | Ubiquitin-Specific Protease 3 Deubiquitinates and Stabilizes Oct4 Protein in Human Embryonic Stem Cells.
Rhie BH, Antao AM, Karapurkar JK, Kim MS, Jo WJ, Ramakrishna S, Kim KS., Free PMC Article | 06/26/2021 |
| LncRNA HOXA-AS3 promotes the malignancy of glioblastoma through regulating miR-455-5p/USP3 axis. | LncRNA HOXA-AS3 promotes the malignancy of glioblastoma through regulating miR-455-5p/USP3 axis.
Chen W, Li Q, Zhang G, Wang H, Zhu Z, Chen L., Free PMC Article | 05/8/2021 |
| An ALYREF-MYCN coactivator complex drives neuroblastoma tumorigenesis through effects on USP3 and MYCN stability. | An ALYREF-MYCN coactivator complex drives neuroblastoma tumorigenesis through effects on USP3 and MYCN stability.
Nagy Z, Seneviratne JA, Kanikevich M, Chang W, Mayoh C, Venkat P, Du Y, Jiang C, Salib A, Koach J, Carter DR, Mittra R, Liu T, Parker MW, Cheung BB, Marshall GM., Free PMC Article | 04/13/2021 |
| USP3 promotes proliferation of non-small cell lung cancer through regulating RBM4. | USP3 promotes proliferation of non-small cell lung cancer through regulating RBM4.
Liao XH, Wang Y, Zhong B, Zhu SY. | 03/20/2021 |
| Smoothened Promotes Glioblastoma Radiation Resistance Via Activating USP3-Mediated Claspin Deubiquitination. | Smoothened Promotes Glioblastoma Radiation Resistance Via Activating USP3-Mediated Claspin Deubiquitination.
Tu Y, Chen Z, Zhao P, Sun G, Bao Z, Chao H, Fan L, Li C, You Y, Qu Y, Chen Y, Ji J. | 01/23/2021 |
| Upregulation of USP3 or downregulation of miR-224-5p restored proliferation and migration by MKN-28 and MGC-803 cells after hsa_circ_0017639 silencing. Upregulation of USP3 restored MKN-28 and MGC-803 cell proliferation and migration after overexpression of miR-224-5p. | Hsa_circ_0017639 expression promotes gastric cancer proliferation and metastasis by sponging miR-224-5p and upregulating USP3.
Li B, Jin M, Cao F, Li J, Wu J, Xu L, Liu X, Shi Y, Chen W. | 07/25/2020 |
| study mechanistically links USP3 to TRAF6 in osteoarthritis development; moreover, data support the pursuit of USP3 and TRAF6 as potential targets for osteoarthritis therapies | Ubiquitin-specific protease 3 targets TRAF6 for deubiquitination and suppresses IL-1β induced chondrocyte apoptosis.
Zhou Q, Xiao Z, Zhou R, Zhou Y, Fu P, Li X, Wu Y, Wu H, Qian Q. | 07/11/2020 |
| USP3 is a new KLF5 deubiquitinase and that USP3 may represent a potential therapeutic target for breast cancer. | USP3 promotes breast cancer cell proliferation by deubiquitinating KLF5.
Wu Y, Qin J, Li F, Yang C, Li Z, Zhou Z, Zhang H, Li Y, Wang X, Liu R, Tao Q, Chen W, Chen C., Free PMC Article | 06/13/2020 |
| SUZ12 is indispensable for USP3-mediated oncogenic activity in gastric cancer . | Ubiquitin-specific protease 3 promotes cell migration and invasion by interacting with and deubiquitinating SUZ12 in gastric cancer.
Wu X, Liu M, Zhu H, Wang J, Dai W, Li J, Zhu D, Tang W, Xiao Y, Lin J, Zhang W, Sun Y, Zhang Y, Chen Y, Li G, Li A, Xiang L, Liu S, Wang J., Free PMC Article | 12/14/2019 |
| as a direct target of miR-224, USP3 is a potent ceRNA of SMAD4 in CRC. Decreased expression of USP3 mRNA is associated with a poor prognosis and distal metastasis of CRC, which is attributed to further suppression of SMAD4 through the release of miR-224 from the USP3 3'UTR. | Downregulated USP3 mRNA functions as a competitive endogenous RNA of SMAD4 by sponging miR-224 and promotes metastasis in colorectal cancer.
Wang Z, Yang J, Di J, Cui M, Xing J, Wu F, Wu W, Yang H, Zhang C, Yao Z, Zhang N, Jiang B, Su X., Free PMC Article | 01/12/2019 |
| Data found that USP3 was overexpressed in gastric cancer (GC) tissues and cells. USP3 overexpression can be a useful biomarker for predicting the outcomes of GC patients. Moreover, USP3 was shown to influence cell proliferation by regulating cell cycle control and metastasis-related proteins. In vivo experiments showed that USP3 promoted GC tumor growth and metastasis. | Ubiquitin-specific protease 3 overexpression promotes gastric carcinogenesis and is predictive of poor patient prognosis.
Fang CL, Lin CC, Chen HK, Hseu YC, Hung ST, Sun DP, Uen YH, Lin KY., Free PMC Article | 11/24/2018 |
| Depletion of USP3 lead to accelerated degradation of p53 in normal cells thereby enhanced cell proliferation and transformation. Reconstitution of wildtype USP3, but not the USP3 C168S mutant, restored the stability of p53 protein and inhibited cell proliferation and transformation. | USP3 stabilizes p53 protein through its deubiquitinase activity.
Fu S, Shao S, Wang L, Liu H, Hou H, Wang Y, Wang H, Huang X, Lv R. | 09/30/2017 |
| Taken together, the results suggested that USP3 is a negative regulator of ubiquitination signaling, counteracting RNF168- and RNF8-mediated ubiquitination. | USP3 counteracts RNF168 via deubiquitinating H2A and γH2AX at lysine 13 and 15.
Sharma N, Zhu Q, Wani G, He J, Wang QE, Wani AA., Free PMC Article | 09/6/2014 |
| the role of UCP3 gene in functional status and survival at old age. | UCP3 polymorphisms, hand grip performance and survival at old age: association analysis in two Danish middle aged and elderly cohorts.
Dato S, Soerensen M, Montesanto A, Lagani V, Passarino G, Christensen K, Christiansen L., Free PMC Article | 01/5/2013 |
| Observational study, meta-analysis, and genome-wide association study of gene-disease association. (HuGE Navigator) | Association of genome-wide variation with the risk of incident heart failure in adults of European and African ancestry: a prospective meta-analysis from the cohorts for heart and aging research in genomic epidemiology (CHARGE) consortium.
Smith NL, Felix JF, Morrison AC, Demissie S, Glazer NL, Loehr LR, Cupples LA, Dehghan A, Lumley T, Rosamond WD, Lieb W, Rivadeneira F, Bis JC, Folsom AR, Benjamin E, Aulchenko YS, Haritunians T, Couper D, Murabito J, Wang YA, Stricker BH, Gottdiener JS, Chang PP, Wang TJ, Rice KM, Hofman A, Heckbert SR, Fox ER, O'Donnell CJ, Uitterlinden AG, Rotter JI, Willerson JT, Levy D, van Duijn CM, Psaty BM, Witteman JC, Boerwinkle E, Vasan RS., Free PMC Article | 06/30/2010 |