| Thrombocytopenia-Absent Radius Syndrome: Descriptions of Three New Cases and a Novel Splicing Variant in RBM8A That Expands the Spectrum of Null Alleles. | Thrombocytopenia-Absent Radius Syndrome: Descriptions of Three New Cases and a Novel Splicing Variant in RBM8A That Expands the Spectrum of Null Alleles.
Monteiro C, Gonçalves A, Oliveira J, Salvado R, Tomaz J, Morais S, Lima M, Santos R., Free PMC Article | 10/22/2022 |
| RBM8A Depletion Decreases the Cisplatin Resistance and Represses the Proliferation and Metastasis of Breast Cancer Cells via AKT/mTOR Pathway. | RBM8A Depletion Decreases the Cisplatin Resistance and Represses the Proliferation and Metastasis of Breast Cancer Cells via AKT/mTOR Pathway.
Song T, Zhang H., Free PMC Article | 10/1/2022 |
| Double-Stranded RNA Structural Elements Holding the Key to Translational Regulation in Cancer: The Case of Editing in RNA-Binding Motif Protein 8A. | Double-Stranded RNA Structural Elements Holding the Key to Translational Regulation in Cancer: The Case of Editing in RNA-Binding Motif Protein 8A.
Abukar A, Wipplinger M, Hariharan A, Sun S, Ronner M, Sculco M, Okonska A, Kresoja-Rakic J, Rehrauer H, Qi W, Beusechem VWV, Felley-Bosco E., Free PMC Article | 01/8/2022 |
| TAR syndrome: Clinical and molecular characterization of a cohort of 26 patients and description of novel noncoding variants of RBM8A. | TAR syndrome: Clinical and molecular characterization of a cohort of 26 patients and description of novel noncoding variants of RBM8A.
Boussion S, Escande F, Jourdain AS, Smol T, Brunelle P, Duhamel C, Alembik Y, Attié-Bitach T, Baujat G, Bazin A, Bonnière M, Carassou P, Carles D, Devisme L, Goizet C, Goldenberg A, Grotto S, Guichet A, Jouk PS, Loeuillet L, Mechler C, Michot C, Pelluard F, Putoux A, Whalen S, Ghoumid J, Manouvrier-Hanu S, Petit F. | 11/6/2021 |
| Identification of molecular correlations of RBM8A with autophagy in Alzheimer's disease. | Identification of molecular correlations of RBM8A with autophagy in Alzheimer's disease.
Zou D, Li R, Huang X, Chen G, Liu Y, Meng Y, Wang Y, Wu Y, Mao Y., Free PMC Article | 10/24/2020 |
| These results demonstrate that data mining efficiently reveals information about RBM8A expression and potential regulatory networks in HCC, laying a foundation for further study of the role of RBM8A in carcinogenesis. | Expression and gene regulation network of RBM8A in hepatocellular carcinoma based on data mining.
Lin Y, Liang R, Qiu Y, Lv Y, Zhang J, Qin G, Yuan C, Liu Z, Li Y, Zou D, Mao Y., Free PMC Article | 04/4/2020 |
| These results reveal that the stability of Magoh and Y14 is not only dependent on the heterodimer structure, but also dependent on nuclear localization. | The stability of Magoh and Y14 depends on their heterodimer formation and nuclear localization.
Ma Q, Tatsuno T, Nakamura Y, Ishigaki Y. | 01/25/2020 |
| Findings demonstrate that Y14 nucleoplasmic localization is regulated not only by the previously reported N-terminal localization signal but also by the C-terminal serine/arginine repeat-containing region through phosphorylation and MAGOH binding to Y14. | C-terminal short arginine/serine repeat sequence-dependent regulation of Y14 (RBM8A) localization.
Tatsuno T, Ishigaki Y., Free PMC Article | 11/24/2018 |
| A direct link between Y14 and p53 expression and suggests a function for Y14 in DNA damage signaling. | Y14 governs p53 expression and modulates DNA damage sensitivity.
Lu CC, Lee CC, Tseng CT, Tarn WY., Free PMC Article | 11/17/2018 |
| Results demonstrated that RBM8A is highly expressed in hepatocellular carcinoma (HCC), and patients with lower RBM8A expression level had longer overall survival and progression free survival. Also, results indicate that RBM8A promotes invasion and metastasis via epithelial-mesenchymal transition signaling pathway. | High expression of RBM8A predicts poor patient prognosis and promotes tumor progression in hepatocellular carcinoma.
Liang R, Lin Y, Ye JZ, Yan XX, Liu ZH, Li YQ, Luo XL, Ye HH. | 04/22/2017 |
| Y14 may selectively and differentially modulate protein biosynthesis. | A Point Mutation in the Exon Junction Complex Factor Y14 Disrupts Its Function in mRNA Cap Binding and Translation Enhancement.
Chuang TW, Lee KM, Lou YC, Lu CC, Tarn WY., Free PMC Article | 10/8/2016 |
| this data suggests a novel role of RBM8a in the regulation of neurodevelopment. | A critical role of RBM8a in proliferation and differentiation of embryonic neural progenitors.
Zou D, McSweeney C, Sebastian A, Reynolds DJ, Dong F, Zhou Y, Deng D, Wang Y, Liu L, Zhu J, Zou J, Shi Y, Albert I, Mao Y., Free PMC Article | 05/14/2016 |
| Mutations of RBM8A and TBX6 are associated with disorders of the mullerian ducts. | Variations in RBM8A and TBX6 are associated with disorders of the müllerian ducts.
Tewes AC, Rall KK, Römer T, Hucke J, Kapczuk K, Brucker S, Wieacker P, Ledig S. | 07/25/2015 |
| It was demonstrated that Rbm8a is an essential neurogenesis regulator in embryonic cortical development. | Rbm8a haploinsufficiency disrupts embryonic cortical development resulting in microcephaly.
Mao H, Pilaz LJ, McMahon JJ, Golzio C, Wu D, Shi L, Katsanis N, Silver DL., Free PMC Article | 07/25/2015 |
| Depletion of RNA-binding protein RBM8A (Y14) causes cell cycle deficiency and apoptosis in human tumor cells. | Depletion of RNA-binding protein RBM8A (Y14) causes cell cycle deficiency and apoptosis in human cells.
Ishigaki Y, Nakamura Y, Tatsuno T, Hashimoto M, Shimasaki T, Iwabuchi K, Tomosugi N. | 02/8/2014 |
| Y14 positively regulates signals for TNF-alpha-induced IL-6 production at multiple steps beyond an exon junction complex protein. | Y14 positively regulates TNF-α-induced NF-κB transcriptional activity via interacting RIP1 and TRADD beyond an exon junction complex protein.
Togi S, Shiga K, Muromoto R, Kato M, Souma Y, Sekine Y, Kon S, Oritani K, Matsuda T. | 10/19/2013 |
| Y14 mutants, which are deficient in binding to Magoh, could still be localized to the nucleus, suggesting the existence of both the nuclear import pathway and function for Y14 unaccompanied by Magoh | Specific Y14 domains mediate its nucleo-cytoplasmic shuttling and association with spliced mRNA.
Kataoka N, Diem MD, Yoshida M, Hatai C, Dobashi I, Dreyfuss G, Hagiwara M, Ohno M., Free PMC Article | 08/3/2013 |
| Data show that Y14 interacts directly with the decapping factor Dcp2 and the 5' cap structure of mRNAs via different but overlapping domains. | The RNA-binding protein Y14 inhibits mRNA decapping and modulates processing body formation.
Chuang TW, Chang WL, Lee KM, Tarn WY., Free PMC Article | 06/8/2013 |
| findings show that the two regulatory SNPs result in diminished RBM8A transcription in vitro and that Y14 expression is reduced in platelets from individuals with thrombocytopenia with absent radii (TAR) | Compound inheritance of a low-frequency regulatory SNP and a rare null mutation in exon-junction complex subunit RBM8A causes TAR syndrome.
Albers CA, Paul DS, Schulze H, Freson K, Stephens JC, Smethurst PA, Jolley JD, Cvejic A, Kostadima M, Bertone P, Breuning MH, Debili N, Deloukas P, Favier R, Fiedler J, Hobbs CM, Huang N, Hurles ME, Kiddle G, Krapels I, Nurden P, Ruivenkamp CA, Sambrook JG, Smith K, Stemple DL, Strauss G, Thys C, van Geet C, Newbury-Ecob R, Ouwehand WH, Ghevaert C., Free PMC Article | 06/2/2012 |
| Y14 provides a regulatory link between pre-mRNA splicing and snRNP biogenesis. | The exon junction complex component Y14 modulates the activity of the methylosome in biogenesis of spliceosomal small nuclear ribonucleoproteins.
Chuang TW, Peng PJ, Tarn WY., Free PMC Article | 05/21/2011 |
| These results indicate that MAGOH regulates the transcriptional activation of STAT3 by interfering complex formation between STAT3 and Y14. | The exon-junction complex proteins, Y14 and MAGOH regulate STAT3 activation.
Muromoto R, Taira N, Ikeda O, Shiga K, Kamitani S, Togi S, Kawakami S, Sekine Y, Nanbo A, Oritani K, Matsuda T. | 01/21/2010 |
| Y14 interacts with STAT3 and regulates the transcriptional activation of STAT3 by influencing the tyrosine-phosphorylation of STAT3. | An RNA biding protein, Y14 interacts with and modulates STAT3 activation.
Ohbayashi N, Taira N, Kawakami S, Togi S, Sato N, Ikeda O, Kamitani S, Muromoto R, Sekine Y, Matsuda T. | 01/21/2010 |
| Increased TAP binding correlates with increased SF2/ASF binding, but not increased REF/Aly or Y14 binding. | Efficiency of the pioneer round of translation affects the cellular site of nonsense-mediated mRNA decay.
Sato H, Hosoda N, Maquat LE. | 01/21/2010 |
| antagonistic post-translational modifications of Y14 may be involved in the remodeling of Y14-containing mRNPs | Phosphorylation of Y14 modulates its interaction with proteins involved in mRNA metabolism and influences its methylation.
Hsu IaW, Hsu M, Li C, Chuang TW, Lin RI, Tarn WY. | 01/21/2010 |
| Tethered function analysis shows that the Y14/hUpf3b interaction is essential for nonsense-mediated decay, while surprisingly the interaction between hUpf3b and hUpf2 is not. | Y14 and hUpf3b form an NMD-activating complex.
Gehring NH, Neu-Yilik G, Schell T, Hentze MW, Kulozik AE. | 01/21/2010 |