Exosomal miRNA-92a derived from cancer-associated fibroblasts promote invasion and metastasis in breast cancer by regulating G3BP2. | Exosomal miRNA-92a derived from cancer-associated fibroblasts promote invasion and metastasis in breast cancer by regulating G3BP2. Sheng Z, Wang X, Ding X, Zheng Y, Guo A, Cui J, Ma J, Duan W, Dong H, Zhang H, Cui M, Su W, Zhang B. | 06/5/2024 |
Chemotherapy-induced exosomal circBACH1 promotes breast cancer resistance and stemness via miR-217/G3BP2 signaling pathway. | Chemotherapy-induced exosomal circBACH1 promotes breast cancer resistance and stemness via miR-217/G3BP2 signaling pathway. Xia W, Chen W, Ni C, Meng X, Wu J, Yang Q, Tang H, Yuan H, Fang S., Free PMC Article | 07/24/2023 |
USP7- and PRMT5-dependent G3BP2 stabilization drives de novo lipogenesis and tumorigenesis of HNSC. | USP7- and PRMT5-dependent G3BP2 stabilization drives de novo lipogenesis and tumorigenesis of HNSC. Wang N, Li T, Liu W, Lin J, Zhang K, Li Z, Huang Y, Shi Y, Xu M, Liu X., Free PMC Article | 03/13/2023 |
EBF1-mediated up-regulation of lncRNA FGD5-AS1 facilitates osteosarcoma progression by regulating miR-124-3p/G3BP2 axis as a ceRNA. | EBF1-mediated up-regulation of lncRNA FGD5-AS1 facilitates osteosarcoma progression by regulating miR-124-3p/G3BP2 axis as a ceRNA. Shuang O, Zhou J, Cai Z, Liao L, Wang Y, Wang W, Xu M., Free PMC Article | 07/2/2022 |
MG53 suppresses tumor progression and stress granule formation by modulating G3BP2 activity in non-small cell lung cancer. | MG53 suppresses tumor progression and stress granule formation by modulating G3BP2 activity in non-small cell lung cancer. Li H, Lin PH, Gupta P, Li X, Zhao SL, Zhou X, Li Z, Wei S, Xu L, Han R, Lu J, Tan T, Yang DH, Chen ZS, Pawlik TM, Merritt RE, Ma J., Free PMC Article | 01/29/2022 |
Genomics-guided targeting of stress granule proteins G3BP1/2 to inhibit SARS-CoV-2 propagation. | Genomics-guided targeting of stress granule proteins G3BP1/2 to inhibit SARS-CoV-2 propagation. Ali N, Prasad K, AlAsmari AF, Alharbi M, Rashid S, Kumar V., Free PMC Article | 10/23/2021 |
BAALC-AS1/G3BP2/c-Myc feedback loop promotes cell proliferation in esophageal squamous cell carcinoma. | BAALC-AS1/G3BP2/c-Myc feedback loop promotes cell proliferation in esophageal squamous cell carcinoma. Zhang H, Wang Y, Zhang W, Wu Q, Fan J, Zhan Q., Free PMC Article | 10/23/2021 |
G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling. | G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling. Prentzell MT, Rehbein U, Cadena Sandoval M, De Meulemeester AS, Baumeister R, Brohée L, Berdel B, Bockwoldt M, Carroll B, Chowdhury SR, von Deimling A, Demetriades C, Figlia G, Genomics England Research Consortium, de Araujo MEG, Heberle AM, Heiland I, Holzwarth B, Huber LA, Jaworski J, Kedra M, Kern K, Kopach A, Korolchuk VI, van 't Land-Kuper I, Macias M, Nellist M, Palm W, Pusch S, Ramos Pittol JM, Reil M, Reintjes A, Reuter F, Sampson JR, Scheldeman C, Siekierska A, Stefan E, Teleman AA, Thomas LE, Torres-Quesada O, Trump S, West HD, de Witte P, Woltering S, Yordanov TE, Zmorzynska J, Opitz CA, Thedieck K., Free PMC Article | 08/28/2021 |
A novel signaling pathway consisting of alpha-parvin, G3BP2, and TWIST1 regulates breast cancer progression and metastasis, this suggests that the activation of this signaling pathway is a key factor for driving the progression and poor clinical outcome of human ER-negative breast cancer. | α-Parvin promotes breast cancer progression and metastasis through interaction with G3BP2 and regulation of TWIST1 signaling. Sun Y, Ding Y, Guo C, Liu C, Ma P, Ma S, Wang Z, Liu J, Qian T, Ma L, Deng Y, Wu C. | 12/14/2019 |
These data confirm that G3BP is a ribosomal binding protein and reveal that alphaviral nsP3 uses G3BP to concentrate viral replication complexes and to recruit the translation initiation machinery, promoting the efficient translation of viral mRNAs. | Separate domains of G3BP promote efficient clustering of alphavirus replication complexes and recruitment of the translation initiation machinery. Götte B, Panas MD, Hellström K, Liu L, Samreen B, Larsson O, Ahola T, McInerney GM., Free PMC Article | 12/7/2019 |
Results found that H. pylori upregulates G3BP2 in human gastric epithelium. In addition, the level of G3BP2 expression increases with severity of gastric malignant lesions in vivo. | Carcinogenic Helicobacter pylori Strains Selectively Dysregulate the In Vivo Gastric Proteome, Which May Be Associated with Stomach Cancer Progression. Noto JM, Rose KL, Hachey AJ, Delgado AG, Romero-Gallo J, Wroblewski LE, Schneider BG, Shah SC, Cover TL, Wilson KT, Israel DA, Roa JC, Schey KL, Zavros Y, Piazuelo MB, Peek RM Jr., Free PMC Article | 11/30/2019 |
Overexpression of TRIM25 promoted prostate cancer cell proliferation and cell survival by modulating p53 nuclear export mechanism with G3BP2 interaction. | TRIM25 enhances cell growth and cell survival by modulating p53 signals via interaction with G3BP2 in prostate cancer. Takayama KI, Suzuki T, Tanaka T, Fujimura T, Takahashi S, Urano T, Ikeda K, Inoue S. | 03/16/2019 |
USP10 was expressed primarily in the cytoplasm of prostate cancer tissues. High levels of USP10 expression were strongly correlated with high levels of AR, G3BP2, and p53 in the cytoplasm. High expression of USP10 was significantly associated with poor prognosis of patients with prostate cancer. | Association of USP10 with G3BP2 Inhibits p53 Signaling and Contributes to Poor Outcome in Prostate Cancer. Takayama KI, Suzuki T, Fujimura T, Takahashi S, Inoue S. | 02/23/2019 |
High G3BP2 levels worsened prognosis in breast cancer. Cell lines with lower G3BP2 levels required substantially higher cell numbers to form tumors in NOD/SCID mice. G3BP2 regulates SART3, Nanog, and Oct-4 expression levels and may be responsible for the maintenance of subpopulations of breast cancer cells with long-term proliferative properties.G3BP2 is important in breast tumor initiation. | Stress granule-associated protein G3BP2 regulates breast tumor initiation. Gupta N, Badeaux M, Liu Y, Naxerova K, Sgroi D, Munn LL, Jain RK, Garkavtsev I., Free PMC Article | 05/12/2018 |
Translocation of p53 is regulated by androgen-dependent sumoylation mediated by the G3BP2-interacting SUMO-E3 ligase, RanBP2. G3BP2 knockdown results in reduced tumor growth and increased nuclear p53 accumulation in mouse xenograft models of prostate cancer with or without long-term androgen deprivation. | Androgen induces G3BP2 and SUMO-mediated p53 nuclear export in prostate cancer. Ashikari D, Takayama K, Tanaka T, Suzuki Y, Obinata D, Fujimura T, Urano T, Takahashi S, Inoue S. | 12/2/2017 |
G3BP mediates the condensation of stress granules by shifting between two different states that are controlled by the phosphorylation of S149 and by binding to Caprin1 or USP10. | G3BP-Caprin1-USP10 complexes mediate stress granule condensation and associate with 40S subunits. Kedersha N, Panas MD, Achorn CA, Lyons S, Tisdale S, Hickman T, Thomas M, Lieberman J, McInerney GM, Ivanov P, Anderson P., Free PMC Article | 08/20/2016 |
FGDF peptide binds and changes conformation of the protruding N-terminal residues by providing hydrophobic interactions to a symmetry related molecule that facilitated crystallization of the G3BP2 isoform. | Crystal structure of the G3BP2 NTF2-like domain in complex with a canonical FGDF motif peptide. Kristensen O. | 04/9/2016 |
G3BP1, G3BP2 and CAPRIN1 are required for translation of interferon stimulated mRNAs and are targeted by a dengue virus non-coding RNA. | G3BP1, G3BP2 and CAPRIN1 are required for translation of interferon stimulated mRNAs and are targeted by a dengue virus non-coding RNA. Bidet K, Dadlani D, Garcia-Blanco MA., Free PMC Article | 11/7/2015 |
Reveal a TWIST1-G3BP2 mechanotransduction pathway that responds to biomechanical signals from the tumour microenvironment to drive EMT, invasion and metastasis. | Matrix stiffness drives epithelial-mesenchymal transition and tumour metastasis through a TWIST1-G3BP2 mechanotransduction pathway. Wei SC, Fattet L, Tsai JH, Guo Y, Pai VH, Majeski HE, Chen AC, Sah RL, Taylor SS, Engler AJ, Yang J., Free PMC Article | 07/25/2015 |
Stress granule components G3BP1 and G3BP2 play a proviral role early in Chikungunya virus replication. | Stress granule components G3BP1 and G3BP2 play a proviral role early in Chikungunya virus replication. Scholte FE, Tas A, Albulescu IC, Žusinaite E, Merits A, Snijder EJ, van Hemert MJ., Free PMC Article | 05/30/2015 |
both G3BP1 and G3BP2 play a role in the formation of SGs in various human cells and thereby recovery from these cellular stresses. | Both G3BP1 and G3BP2 contribute to stress granule formation. Matsuki H, Takahashi M, Higuchi M, Makokha GN, Oie M, Fujii M. | 06/29/2013 |
Data show that the nsP3/G3BP interaction also blocks stress granules (SGs) induced by other stresses than virus infection. | Sequestration of G3BP coupled with efficient translation inhibits stress granules in Semliki Forest virus infection. Panas MD, Varjak M, Lulla A, Eng KE, Merits A, Karlsson Hedestam GB, McInerney GM., Free PMC Article | 06/8/2013 |
first evidence of direct interactions between PKCalpha and G3BP2 and that PKCalpha can phosphorylate G3BP2. | PKCα binds G3BP2 and regulates stress granule formation following cellular stress. Kobayashi T, Winslow S, Sunesson L, Hellman U, Larsson C., Free PMC Article | 09/1/2012 |
We showed that just four genes, G3BP2, SCARB2, CSNK1A1 and SPRR2B, can classify patients as presence of lymph node metastasis negative or positive, with 80.0% accuracy. | Four-gene expression model predictive of lymph node metastases in oral squamous cell carcinoma. Pasini FS, Maistro S, Snitcovsky I, Barbeta LP, Rotea Mangone FR, Lehn CN, Walder F, Carvalho MB, Brentani MM, Federico MH. | 03/31/2012 |
Both G3BP1 and G3BP2 isoforms may act as negative regulators of tumor suppressor protein p53. | Modulation of p53 and MDM2 activity by novel interaction with Ras-GAP binding proteins (G3BP). Kim MM, Wiederschain D, Kennedy D, Hansen E, Yuan ZM. | 01/21/2010 |