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    UBAP2L ubiquitin associated protein 2 like [ Homo sapiens (human) ]

    Gene ID: 9898, updated on 3-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    UBAP2L ensures homeostasis of nuclear pore complexes at the intact nuclear envelope.

    UBAP2L ensures homeostasis of nuclear pore complexes at the intact nuclear envelope.
    Liao Y, Andronov L, Liu X, Lin J, Guerber L, Lu L, Agote-Arán A, Pangou E, Ran L, Kleiss C, Qu M, Schmucker S, Cirillo L, Zhang Z, Riveline D, Gotta M, Klaholz BP, Sumara I., Free PMC Article

    05/7/2024
    UBAP2L-dependent coupling of PLK1 localization and stability during mitosis.

    UBAP2L-dependent coupling of PLK1 localization and stability during mitosis.
    Guerber L, Vuidel A, Liao Y, Kleiss C, Grandgirard E, Sumara I, Pangou E., Free PMC Article

    06/12/2023
    UBAP2/UBAP2L regulate UV-induced ubiquitylation of RNA polymerase II and are the human orthologues of yeast Def1.

    UBAP2/UBAP2L regulate UV-induced ubiquitylation of RNA polymerase II and are the human orthologues of yeast Def1.
    Herlihy AE, Boeing S, Weems JC, Walker J, Dirac-Svejstrup AB, Lehner MH, Conaway RC, Conaway JW, Svejstrup JQ.

    06/11/2022
    Ubiquitin-associated protein 2 like (UBAP2L) enhances growth and metastasis of gastric cancer cells.

    Ubiquitin-associated protein 2 like (UBAP2L) enhances growth and metastasis of gastric cancer cells.
    Lin S, Yan Z, Tang Q, Zhang S., Free PMC Article

    02/19/2022
    Molecular Insights into the Recruiting Between UCP2 and DDX5/UBAP2L in the Metabolic Plasticity of Non-Small-Cell Lung Cancer.

    Molecular Insights into the Recruiting Between UCP2 and DDX5/UBAP2L in the Metabolic Plasticity of Non-Small-Cell Lung Cancer.
    Yang Z, Li G, Zhao Y, Zhang L, Yuan X, Meng L, Liu H, Han Y, Jia L, Zhang S.

    10/23/2021
    UBAP2L arginine methylation by PRMT1 modulates stress granule assembly.

    UBAP2L arginine methylation by PRMT1 modulates stress granule assembly.
    Huang C, Chen Y, Dai H, Zhang H, Xie M, Zhang H, Chen F, Kang X, Bai X, Chen Z., Free PMC Article

    04/3/2021
    UBAP2L Forms Distinct Cores that Act in Nucleating Stress Granules Upstream of G3BP1.

    UBAP2L Forms Distinct Cores that Act in Nucleating Stress Granules Upstream of G3BP1.
    Cirillo L, Cieren A, Barbieri S, Khong A, Schwager F, Parker R, Gotta M.

    01/16/2021
    Large-scale tethered function assays identify factors that regulate mRNA stability and translation.

    Large-scale tethered function assays identify factors that regulate mRNA stability and translation.
    Luo EC, Nathanson JL, Tan FE, Schwartz JL, Schmok JC, Shankar A, Markmiller S, Yee BA, Sathe S, Pratt GA, Scaletta DB, Ha Y, Hill DE, Aigner S, Yeo GW., Free PMC Article

    12/19/2020
    Patients with high UBAP2L expression had unfavorable prognosis and UBAP2L appears to play an important role in proliferation.

    Clinical Significance of Ubiquitin-associated Protein 2-like in Patients With Uterine Cervical Cancer.
    Yoshida K, Kajiyama H, Inami E, Tamauchi S, Ikeda Y, Yoshikawa N, Nishino K, Utsumi F, Niimi K, Suzuki S, Shibata K, Nawa A, Kikkawa F., Free PMC Article

    06/6/2020
    UBAP2L plays an oncogenic role in HCC, and knockdown of its expression significantly inhibits HCC growth and metastasis, which may be related to the regulation of PI3K/AKT and P53 signaling pathways by UBAP2L.

    Knockdown of Ubiquitin Associated Protein 2-Like (UBAP2L) Inhibits Growth and Metastasis of Hepatocellular Carcinoma.
    Li Q, Wang W, Hu YC, Yin TT, He J., Free PMC Article

    12/22/2018
    High UBAP2L expression is associated with breast cancer.

    UBAP2L silencing inhibits cell proliferation and G2/M phase transition in breast cancer.
    He J, Chen Y, Cai L, Li Z, Guo X., Free PMC Article

    09/1/2018
    UBAP2L was overexpressed in HCC, and patients with high UBAP2L expression had unfavorable prognosis.

    Ubiquitin Associated Protein 2-Like (UBAP2L) Overexpression in Patients with Hepatocellular Carcinoma and its Clinical Significance.
    Wang W, Zhang M, Peng Y, He J., Free PMC Article

    06/16/2018
    UBAP2L is amplified in 15% of human primary lung adenocarcinoma specimens. Such patients express higher levels of UBAP2L and show a reduction in survival when compared with those who do not have this gene amplification.

    UBAP2L is amplified in a large subset of human lung adenocarcinoma and is critical for epithelial lung cell identity and tumor metastasis.
    Aucagne R, Girard S, Mayotte N, Lehnertz B, Lopes-Paciencia S, Gendron P, Boucher G, Chagraoui J, Sauvageau G.

    11/26/2017
    UBAP2L plays a critical role in maintenance of the metastatic ability of Hepatocellular Carcinoma Cells cells via SNAIL1 Regulation and is predictive of a poor clinical outcome.

    Downregulation of UBAP2L Inhibits the Epithelial-Mesenchymal Transition via SNAIL1 Regulation in Hepatocellular Carcinoma Cells.
    Ye T, Xu J, Du L, Mo W, Liang Y, Xia J.

    06/24/2017
    These results suggest that UBAP2L has a key role in glioma cell growth, and may act as an oncogene to promote malignant glioma development.

    Downregulation of ubiquitin-associated protein 2-like with a short hairpin RNA inhibits human glioma cell growth in vitro.
    Zhao B, Zong G, Xie Y, Li J, Wang H, Bian E., Free PMC Article

    06/28/2016
    arginine residues in the RGG/RG motif of UBAP2L were directly methylated by PRMT1. RGG/RG motif of UBAP2L is essential for the proper alignment of chromosomes.

    Arginine methylation of ubiquitin-associated protein 2-like is required for the accurate distribution of chromosomes.
    Maeda M, Hasegawa H, Sugiyama M, Hyodo T, Ito S, Chen D, Asano E, Masuda A, Hasegawa Y, Hamaguchi M, Senga T.

    06/11/2016
    Knockdown of UBAP2L in prostate carcinoma inhibited cell proliferation, migration, and colony formation ability, and blocked cell cycle progression.

    Knockdown of ubiquitin associated protein 2-like inhibits the growth and migration of prostate cancer cells.
    Li D, Huang Y.

    06/6/2015
    Two different BMI1-containing PcG complexes regulate hematopoietic stem cell activity, which are distinguishable by the presence of UBAP2L.

    UBAP2L is a novel BMI1-interacting protein essential for hematopoietic stem cell activity.
    Bordeleau ME, Aucagne R, Chagraoui J, Girard S, Mayotte N, Bonneil E, Thibault P, Pabst C, Bergeron A, Barabé F, Hébert J, Sauvageau M, Boutonnet C, Meloche S, Sauvageau G., Free PMC Article

    03/7/2015
    Observational study of gene-disease association. (HuGE Navigator)See all PubMed (2) articles

    New genetic associations detected in a host response study to hepatitis B vaccine.
    Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M.

    Replication of previous genome-wide association studies of bone mineral density in premenopausal American women.
    Ichikawa S, Koller DL, Padgett LR, Lai D, Hui SL, Peacock M, Foroud T, Econs MJ.

    04/7/2010
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