| The Orf9b protein of SARS-CoV-2 modulates mitochondrial protein biogenesis. | The Orf9b protein of SARS-CoV-2 modulates mitochondrial protein biogenesis.
Lenhard S, Gerlich S, Khan A, Rödl S, Bökenkamp JE, Peker E, Zarges C, Faust J, Storchova Z, Räschle M, Riemer J, Herrmann JM., Free PMC Article | 09/11/2023 |
| Mitochondria shed their outer membrane in response to infection-induced stress. | Mitochondria shed their outer membrane in response to infection-induced stress.
Li X, Straub J, Medeiros TC, Mehra C, den Brave F, Peker E, Atanassov I, Stillger K, Michaelis JB, Burbridge E, Adrain C, Münch C, Riemer J, Becker T, Pernas LF. | 01/29/2022 |
| Relation between ORF8a and the mitochondrial protein TOM70 in SARS-CoV-2 infection. | Relation between ORF8a and the mitochondrial protein TOM70 in SARS-CoV-2 infection.
Zandi M, Soltani S., Free PMC Article | 01/1/2022 |
| Phosphorylation of SARS-CoV-2 Orf9b Regulates Its Targeting to Two Binding Sites in TOM70 and Recruitment of Hsp90. | Phosphorylation of SARS-CoV-2 Orf9b Regulates Its Targeting to Two Binding Sites in TOM70 and Recruitment of Hsp90.
Brandherm L, Kobaš AM, Klöhn M, Brüggemann Y, Pfaender S, Rassow J, Kreimendahl S., Free PMC Article | 09/18/2021 |
| De novo mutations in TOMM70, a receptor of the mitochondrial import translocase, cause neurological impairment. | De novo mutations in TOMM70, a receptor of the mitochondrial import translocase, cause neurological impairment.
Dutta D, Briere LC, Kanca O, Marcogliese PC, Walker MA, High FA, Vanderver A, Krier J, Carmichael N, Callahan C, Taft RJ, Simons C, Helman G, Network UD, Wangler MF, Yamamoto S, Sweetser DA, Bellen HJ., Free PMC Article | 08/14/2021 |
| Crystal structure of SARS-CoV-2 Orf9b in complex with human TOM70 suggests unusual virus-host interactions. | Crystal structure of SARS-CoV-2 Orf9b in complex with human TOM70 suggests unusual virus-host interactions.
Gao X, Zhu K, Qin B, Olieric V, Wang M, Cui S., Free PMC Article | 06/5/2021 |
| Mutations in TOMM70 lead to multi-OXPHOS deficiencies and cause severe anemia, lactic acidosis, and developmental delay. | Mutations in TOMM70 lead to multi-OXPHOS deficiencies and cause severe anemia, lactic acidosis, and developmental delay.
Wei X, Du M, Xie J, Luo T, Zhou Y, Zhang K, Li J, Chen D, Xu P, Jia M, Zhou H, Fang H, Lyu J, Yang Y. | 10/10/2020 |
| SARS-CoV-2 Orf9b suppresses type I interferon responses by targeting TOM70. | SARS-CoV-2 Orf9b suppresses type I interferon responses by targeting TOM70.
Jiang HW, Zhang HN, Meng QF, Xie J, Li Y, Chen H, Zheng YX, Wang XN, Qi H, Zhang J, Wang PH, Han ZG, Tao SC., Free PMC Article | 09/19/2020 |
| TOM70, but not TOM20, clusters in distinct OMM foci, frequently overlapping with sites in which the endoplasmic reticulum (ER) contacts mitochondria. Functionally, TOM70 depletion specifically impairs inositol trisphosphates (IP3)-linked ER to mitochondria Ca(2+) transfer. This phenomenon is dependent on the capacity of TOM70 to interact with IP3-receptors and favor their functional recruitment close to mitochondria. | TOM70 Sustains Cell Bioenergetics by Promoting IP3R3-Mediated ER to Mitochondria Ca(2+) Transfer.
Filadi R, Leal NS, Schreiner B, Rossi A, Dentoni G, Pinho CM, Wiehager B, Cieri D, Calì T, Pizzo P, Ankarcrona M. | 07/6/2019 |
| Collectively, this study characterizes a novel protein complex, Tom70/Hsp90/IRF3/Bax, that is important for Sendai virus-induced apoptosis. | Tom70 mediates Sendai virus-induced apoptosis on mitochondria.
Wei B, Cui Y, Huang Y, Liu H, Li L, Li M, Ruan KC, Zhou Q, Wang C., Free PMC Article | 05/23/2015 |
| Tom70 acts as a molecular switch that orchestrates hypertrophic stresses and mitochondrial responses to determine pathological cardiac hypertrophy. | Tom70 serves as a molecular switch to determine pathological cardiac hypertrophy.
Li J, Qi M, Li C, Shi D, Zhang D, Xie D, Yuan T, Feng J, Liu Y, Liang D, Xu X, Chen J, Xu L, Zhang H, Ye J, Lv F, Huang J, Peng L, Chen YH., Free PMC Article | 04/4/2015 |
| Blockade of mitochondrial protein import triggers the recruitment of PARK2, by PINK1, to the TOMM machinery. | The TOMM machinery is a molecular switch in PINK1 and PARK2/PARKIN-dependent mitochondrial clearance.
Bertolin G, Ferrando-Miguel R, Jacoupy M, Traver S, Grenier K, Greene AW, Dauphin A, Waharte F, Bayot A, Salamero J, Lombès A, Bulteau AL, Fon EA, Brice A, Corti O. | 06/21/2014 |
| PINK1 is imported into mitochondria by a unique pathway that is independent of the TOM core complex but crucially depends on the import receptor Tom70 | Tom70 is essential for PINK1 import into mitochondria.
Kato H, Lu Q, Rapaport D, Kozjak-Pavlovic V., Free PMC Article | 12/7/2013 |
| The hepatitis C virus NS3/4A protein induced Tom70 expression. | Translocase of outer mitochondrial membrane 70 induces interferon response and is impaired by hepatitis C virus NS3.
Kasama Y, Saito M, Takano T, Nishimura T, Satoh M, Wang Z, Ali SN, Harada S, Kohara M, Tsukiyama-Kohara K. | 05/5/2012 |
| a novel model in which Tom20 binds Tom70 to facilitate preprotein release from the chaperones by competition | Interaction between the human mitochondrial import receptors Tom20 and Tom70 in vitro suggests a chaperone displacement mechanism.
Fan AC, Kozlov G, Hoegl A, Marcellus RC, Wong MJ, Gehring K, Young JC., Free PMC Article | 11/26/2011 |
| used biophysical tools to study the interaction between the C-terminal domain of Hsp90 (C-Hsp90), which contains the EEVD motif that binds to TPR domains, and the cytosolic fragment of Tom70 | Stoichiometry and thermodynamics of the interaction between the C-terminus of human 90kDa heat shock protein Hsp90 and the mitochondrial translocase of outer membrane Tom70.
Gava LM, Gonçalves DC, Borges JC, Ramos CH. | 10/15/2011 |
| This study revealed a novel finding, that is, human TOM70 is linked with the hepatitis C virus NS3 protein and the apoptotic response. | Translocase of outer mitochondrial membrane 70 expression is induced by hepatitis C virus and is related to the apoptotic response.
Takano T, Kohara M, Kasama Y, Nishimura T, Saito M, Kai C, Tsukiyama-Kohara K. | 07/16/2011 |
| Tom70 as a critical adaptor linking MAVS to TBK1/IRF3, revealing that mitochondrion is evolutionarily integrated with innate immunity. | Tom70 mediates activation of interferon regulatory factor 3 on mitochondria.
Liu XY, Wei B, Shi HX, Shan YF, Wang C. | 01/1/2011 |
| Observational study of gene-disease association. (HuGE Navigator) | Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ., Free PMC Article | 12/5/2010 |
| results indicate that the Tom70 monomers are the functional form of the receptor, whereas the homodimers appear to be a minor population, and may represent an inactive state | Human mitochondrial import receptor Tom70 functions as a monomer.
Fan AC, Gava LM, Ramos CH, Young JC., Free PMC Article | 08/2/2010 |
| nuclear respiratory factor-2 binding site methylation suppresses the promoter activity of the human TOMM70 gene | In vitro methylation of nuclear respiratory factor-2 binding sites suppresses the promoter activity of the human TOMM70 gene.
Blesa JR, Hegde AA, Hernández-Yago J. | 01/21/2010 |
| S100A2 and S100A6 interact with another TPR protein Tom70 and regulate the Tom70-ligand interaction in vitro | Interactions of S100A2 and S100A6 with the tetratricopeptide repeat proteins, Hsp90/Hsp70-organizing protein and kinesin light chain.
Shimamoto S, Takata M, Tokuda M, Oohira F, Tokumitsu H, Kobayashi R., Free PMC Article | 01/21/2010 |
| The internal EELD domain facilitates mitochondrial targeting of Mcl-1 via a Tom70-dependent pathway. | An internal EELD domain facilitates mitochondrial targeting of Mcl-1 via a Tom70-dependent pathway.
Chou CH, Lee RS, Yang-Yen HF., Free PMC Article | 01/21/2010 |
| TOMM70A is ubiquitously expressed in human tissues, maps on chromosome 3q13.1-q13.2 and consists of 12 coding exons spanning over 37 kb. | Characterization of a human import component of the mitochondrial outer membrane, TOMM70A.
Edmonson AM, Mayfield DK, Vervoort V, DuPont BR, Argyropoulos G. | 01/21/2010 |
| suggests a novel active role for Hsp90 in import steps subsequent to Tom70 targeting. | Hsp90 functions in the targeting and outer membrane translocation steps of Tom70-mediated mitochondrial import.
Fan AC, Bhangoo MK, Young JC. | 01/21/2010 |