| TRIM14 Overexpression Induces Chemoresistance and Malignant Behaviors of Hepatocellular Carcinoma Cells by Activating the STAT3/HIF-1alpha Pathway. | TRIM14 Overexpression Induces Chemoresistance and Malignant Behaviors of Hepatocellular Carcinoma Cells by Activating the STAT3/HIF-1α Pathway.
Xu W, Zhuang L, Zhu H, Mao A, Zhou J, Wang L., Free PMC Article | 08/30/2023 |
| Circular RNA circ_0048764 promotes the development of breast cancer by regulating microRNA-1296-5p/tripartite motif containing 14 axis. | Circular RNA circ_0048764 promotes the development of breast cancer by regulating microRNA-1296-5p/tripartite motif containing 14 axis.
Xie F, Xiong Y, Yan J, Wang L, Yan W., Free PMC Article | 02/26/2022 |
| Human mesenchymal stem cells derived exosomes inhibit the growth of acute myeloid leukemia cells via regulating miR-23b-5p/TRIM14 pathway. | Human mesenchymal stem cells derived exosomes inhibit the growth of acute myeloid leukemia cells via regulating miR-23b-5p/TRIM14 pathway.
Cheng H, Ding J, Tang G, Huang A, Gao L, Yang J, Chen L., Free PMC Article | 02/26/2022 |
| miR-671-5p repressed progression of papillary thyroid carcinoma via TRIM14. | miR-671-5p repressed progression of papillary thyroid carcinoma via TRIM14.
Wang WJ, Yuan Y, Zhang D, Liu P, Liu F. | 02/19/2022 |
| Human TRIM14 protects transgenic mice from influenza A viral infection without activation of other innate immunity pathways. | Human TRIM14 protects transgenic mice from influenza A viral infection without activation of other innate immunity pathways.
Nenasheva VV, Nikitenko NA, Stepanenko EA, Makarova IV, Andreeva LE, Kovaleva GV, Lysenko AA, Tukhvatulin AI, Logunov DY, Tarantul VZ. | 01/22/2022 |
| miR-4443 targets TRIM14 to suppress metastasis and energy metabolism of papillary thyroid carcinoma (PTC) in vitro. | miR-4443 targets TRIM14 to suppress metastasis and energy metabolism of papillary thyroid carcinoma (PTC) in vitro.
Zuo XM, Sun HW, Fang H, Wu Y, Shi Q, Yu YF. | 01/15/2022 |
| Trim14 promotes autophagy and chemotherapy resistance of gastric cancer cells by regulating AMPK/mTOR pathway. | Trim14 promotes autophagy and chemotherapy resistance of gastric cancer cells by regulating AMPK/mTOR pathway.
Xiao F, Ouyang B, Zou J, Yang Y, Yi L, Yan H. | 09/4/2021 |
| TRIM14 regulates melanoma malignancy via PTEN/PI3K/AKT and STAT3 pathways. | TRIM14 regulates melanoma malignancy via PTEN/PI3K/AKT and STAT3 pathways.
Chen J, Huang L, Quan J, Xiang D., Free PMC Article | 07/24/2021 |
| TRIM14 may be a prognostic factor and oncogene in papillary thyroid carcinoma | Tripartite motif containing 14: An oncogene in papillary thyroid carcinoma.
Sun W, Wang Y, Li D, Wu Y, Ji Q, Sun T. | 08/1/2020 |
| The crystal structure of the TRIM14 PRYSPRY domain was solved, and found a positively charged surface that may mediate its partner specificity. TRIM14 PRYSPRY domain binds to acidic peptides, and the analysis of the reported partners of TRIM14 is consistent with this assumption. | The TRIM14 PRYSPRY domain mediates protein interaction via its basic interface.
Yu Y, Liang L, Jin Y, Yin Y. | 06/6/2020 |
| Knockdown of IRF-1 reduces the stimulation of TRIM14 transcription by IFN-alpha, suggesting that IRF-1 is involved in the activation of TRIM14 by IFN-I. IRF-2 has little effect on IFN-alpha-induced TRIM14 transcription but is essential for the basal transcription of TRIM14. | TRIM14 expression is regulated by IRF-1 and IRF-2.
Cui J, Xu X, Li Y, Hu X, Xie Y, Tan J, Qiao W., Free PMC Article | 03/14/2020 |
| the function of TRIM14 and NF-kappaB signalling and might | TNF-α induces apoptosis of human nucleus pulposus cells via activating the TRIM14/NF-κB signalling pathway.
Zhu H, Sun B, Shen Q. | 12/21/2019 |
| this study demonstrates that TRIM14 is a STAT1-dependent IFN-stimulated gene, and that the IFN-I-TRIM14-HBx axis shows an alternative way to understand the mechanism by which IFN-I inhibits virus replication | Identification of TRIM14 as a Type I IFN-Stimulated Gene Controlling Hepatitis B Virus Replication by Targeting HBx.
Tan G, Xu F, Song H, Yuan Y, Xiao Q, Ma F, Qin FX, Cheng G., Free PMC Article | 10/5/2019 |
| TRIM14 was upregulated in both tissues and cell lines of human breast cancer. Knockdown of TRIM14 inhibited cell proliferation but increased cell apoptosis. | TRIM14 Promotes Breast Cancer Cell Proliferation by Inhibiting Apoptosis.
Hu G, Pen W, Wang M., Free PMC Article | 04/27/2019 |
| TRIM14 promotes chemoresistance in gliomas by activating Wnt/beta-catenin signaling via stabilizing Dvl2 | TRIM14 promotes chemoresistance in gliomas by activating Wnt/β-catenin signaling via stabilizing Dvl2.
Tan Z, Song L, Wu W, Zhou Y, Zhu J, Wu G, Cao L, Song J, Li J, Zhang W. | 02/23/2019 |
| Results showed that TRIM14 is increased in gastric cancer (GC) tissues and cell lines and associated with malignant features and unfavorable prognosis. Gain and lossoffunctional data confirmed that TRIM14 promotes migration, invasion and EMT progression by activating AKT signaling. TRIM14 was found to function as an oncogene in regulating EMT and metastasis of GC via AKT signaling, which was regulated by miR195. | TRIM14 promotes the migration and invasion of gastric cancer by regulating epithelial‑to‑mesenchymal transition via activation of AKT signaling regulated by miR‑195‑5p.
Wang F, Ruan L, Yang J, Zhao Q, Wei W., Free PMC Article | 12/22/2018 |
| Our findings collectively suggest that TRIM14 functions as an oncogene by upregulating the AKT signaling pathway in osteosarcoma cells, supporting its potential utility as a therapeutic target for this disease. | TRIM14 regulates cell proliferation and invasion in osteosarcoma via promotion of the AKT signaling pathway.
Xu G, Guo Y, Xu D, Wang Y, Shen Y, Wang F, Lv Y, Song F, Jiang D, Zhang Y, Lou Y, Meng Y, Yang Y, Kang Y., Free PMC Article | 11/3/2018 |
| Study shows that tripartite Motif 14 (TRIM14) is a putative tumor suppressor and regulator of innate immune response in non-small cell lung cancer. The functional data establishes a novel tumor suppressive role for TRIM14 in non-small cell lung cancer progression. | TRIM14 is a Putative Tumor Suppressor and Regulator of Innate Immune Response in Non-Small Cell Lung Cancer.
Hai J, Zhu CQ, Wang T, Organ SL, Shepherd FA, Tsao MS., Free PMC Article | 10/20/2018 |
| we identify the tripartite motif-containing protein (TRIM14) as a target of miR-195-5p. Therefore, we reason that the tumor suppressor role of miR-195-5p in oral squamous cell carcinoma is dependent on the interaction with TRIM14. | miR-195-5p Suppresses the Proliferation, Migration, and Invasion of Oral Squamous Cell Carcinoma by Targeting TRIM14.
Wang T, Ren Y, Liu R, Ma J, Shi Y, Zhang L, Bu R., Free PMC Article | 08/4/2018 |
| In searching for mechanisms how TRIM14 exerts its antiviral function we found that TRIM14 interacted with HCV encoded non-structural protein NS5A and could strongly induce its degradation dependent on the NS5A1 subdomain. Interestingly extensive domain mapping analyses revealed that NS5A degradation was mediated by the highly conserved SPRY domain of TRIM14, which might involve the K48 ubiquitination pathway | TRIM14 inhibits hepatitis C virus infection by SPRY domain-dependent targeted degradation of the viral NS5A protein.
Wang S, Chen Y, Li C, Wu Y, Guo L, Peng C, Huang Y, Cheng G, Qin FX., Free PMC Article | 05/26/2018 |
| findings define the WHIP-TRIM14-PPP6C mitochondrial signalosome required for RIG-I-mediated innate antiviral immunity. | Assembly of the WHIP-TRIM14-PPP6C Mitochondrial Complex Promotes RIG-I-Mediated Antiviral Signaling.
Tan P, He L, Cui J, Qian C, Cao X, Lin M, Zhu Q, Li Y, Xing C, Yu X, Wang HY, Wang RF. | 10/28/2017 |
| study identifies new gene-type zinc finger protein 125 (RNF125) as a negative regulator of TRIM14 in the innate antiviral immune response | The Ubiquitin Ligase RNF125 Targets Innate Immune Adaptor Protein TRIM14 for Ubiquitination and Degradation.
Jia X, Zhou H, Wu C, Wu Q, Ma S, Wei C, Cao Y, Song J, Zhong H, Zhou Z, Wang J. | 09/30/2017 |
| survival of xenograft mice was prolonged by BsAbBmi/TRIM treatment compared to either AbBmi-1 or AbTRIM-14 treatment. In conclusion, these results provided new evidence that BsAbBmi/TRIM inhibited the progression of osteosarcoma, which suggest that BsAbBmi/TRIM may be a novel anti-cancer agent for osteosarcoma therapy | Bispecific antibody suppresses osteosarcoma aggressiveness through regulation of NF-κB signaling pathway.
Yu GH, Li AM, Li X, Yang Z, Peng H. | 07/22/2017 |
| MiR-15b degrades TRIM14 in oral tongue squamous cell cancer.TRIM14 role in oral tongue squamous cell cancer resistance to cisplatin. | miR-15b inhibits cancer-initiating cell phenotypes and chemoresistance of cisplatin by targeting TRIM14 in oral tongue squamous cell cancer.
Wang X, Guo H, Yao B, Helms J. | 06/24/2017 |
| Data suggest that tripartite motif containing 14 protein (TRIM14) might play an important role in the malignant progression of tongue squamous cells carcinoma (TSCC) and in regulation of the NF_Kappa B (NF-kappaB) signaling pathway. | Overexpression of TRIM14 promotes tongue squamous cell carcinoma aggressiveness by activating the NF-κB signaling pathway.
Su X, Wang J, Chen W, Li Z, Fu X, Yang A., Free PMC Article | 01/28/2017 |