| Hypoxia-inducible factor 1 recruits FACT and RNF20/40 to mediate histone ubiquitination and transcriptional activation of target genes. | Hypoxia-inducible factor 1 recruits FACT and RNF20/40 to mediate histone ubiquitination and transcriptional activation of target genes.
Lyu Y, Yang Y, Talwar V, Lu H, Chen C, Salman S, Wicks EE, Huang TY, Drehmer D, Wang Y, Zuo Q, Datan E, Jackson W 3rd, Dordai D, Wang R, Semenza GL. | 05/8/2024 |
| RNF40 epigenetically modulates glycolysis to support the aggressiveness of basal-like breast cancer. | RNF40 epigenetically modulates glycolysis to support the aggressiveness of basal-like breast cancer.
Prokakis E, Jansari S, Boshnakovska A, Wiese M, Kusch K, Kramm C, Dullin C, Rehling P, Glatzel M, Pantel K, Wikman H, Johnsen SA, Gallwas J, Wegwitz F., Free PMC Article | 10/2/2023 |
| Epigenetic modification and a role for the E3 ligase RNF40 in cancer development and metastasis. | Epigenetic modification and a role for the E3 ligase RNF40 in cancer development and metastasis.
Fu J, Liao L, Balaji KS, Wei C, Kim J, Peng J., Free PMC Article | 07/31/2021 |
| The histone H2B ubiquitin ligase RNF40 is required for HER2-driven mammary tumorigenesis. | The histone H2B ubiquitin ligase RNF40 is required for HER2-driven mammary tumorigenesis.
Wegwitz F, Prokakis E, Pejkovska A, Kosinsky RL, Glatzel M, Pantel K, Wikman H, Johnsen SA., Free PMC Article | 05/15/2021 |
| The H2B ubiquitin-protein ligase RNF40 is required for somatic cell reprogramming. | The H2B ubiquitin-protein ligase RNF40 is required for somatic cell reprogramming.
Xie W, Miehe M, Laufer S, Johnsen SA., Free PMC Article | 04/3/2021 |
| The RNF20/40 complex regulates p53-dependent gene transcription and mRNA splicing. | The RNF20/40 complex regulates p53-dependent gene transcription and mRNA splicing.
Wu C, Cui Y, Liu X, Zhang F, Lu LY, Yu X., Free PMC Article | 02/13/2021 |
| Findings reveal that RNF40 is essential for maintaining tumorigenic features of colorectal cancer cells in vitro by controlling the expression of genes encoding central apoptotic regulators. | The E3 ubiquitin ligase RNF40 suppresses apoptosis in colorectal cancer cells.
Schneider D, Chua RL, Molitor N, Hamdan FH, Rettenmeier EM, Prokakis E, Mishra VK, Kari V, Wegwitz F, Johnsen SA, Kosinsky RL., Free PMC Article | 05/30/2020 |
| Cooperative physical interactions among eEF1BdeltaL, RNF20/40, and HSF1 synergistically promote expression of heat shock-responsive genes. In addition, eEF1BdeltaL is a novel ubiquitylation target of RNF20/40 and elucidating its function. This provides a molecular mechanism for the cooperative function of distinct transcription factors in heat shock-responsive gene transcription. | RNF20/40-mediated eEF1BδL monoubiquitylation stimulates transcription of heat shock-responsive genes.
In S, Kim YI, Lee JE, Kim J., Free PMC Article | 11/16/2019 |
| Our findings suggest that RNF40 plays a central role in the maintenance of tumorigenic features and inflammatory signaling by promoting nuclear NF-kappaB activity. | Loss of RNF40 Decreases NF-κB Activity in Colorectal Cancer Cells and Reduces Colitis Burden in Mice.
Kosinsky RL, Chua RL, Qui M, Saul D, Mehlich D, Ströbel P, Schildhaus HU, Wegwitz F, Faubion WA, Johnsen SA., Free PMC Article | 08/24/2019 |
| the RNF20/40 complex, a major ubiquitin ligase catalysing histone H2B monoubiquitination, interacts with the motor protein Eg5 during mitosis and participates in spindle assembly. | Ubiquitin ligase RNF20/40 facilitates spindle assembly and promotes breast carcinogenesis through stabilizing motor protein Eg5.
Duan Y, Huo D, Gao J, Wu H, Ye Z, Liu Z, Zhang K, Shan L, Zhou X, Wang Y, Su D, Ding X, Shi L, Wang Y, Shang Y, Xuan C., Free PMC Article | 09/8/2018 |
| The authors also show that the RING domains of RNF20 and RNF40 can form a stable heterodimer that is active. | Structure and Function of the RING Domains of RNF20 and RNF40, Dimeric E3 Ligases that Monoubiquitylate Histone H2B.
Foglizzo M, Middleton AJ, Day CL. | 06/24/2017 |
| Manipulation of key H2Bub1 E3 ubiquitin ligases, RNF20, RNF40 and BRCA1, in ovarian cancer cell line models modulated H2Bub1 levels, indicative of the role of these RING finger ligases in monoubiquitination of H2Bub1 in vitro | The RING finger domain E3 ubiquitin ligases BRCA1 and the RNF20/RNF40 complex in global loss of the chromatin mark histone H2B monoubiquitination (H2Bub1) in cell line models and primary high-grade serous ovarian cancer.
Dickson KA, Cole AJ, Gill AJ, Clarkson A, Gard GB, Chou A, Kennedy CJ, Henderson BR, Australian Ovarian Cancer Study (AOCS), Fereday S, Traficante N, Alsop K, Bowtell DD, deFazio A, Clifton-Bligh R, Marsh DJ. | 06/10/2017 |
| We show that Bre1 (human BRE1A/B (RNF20/40) and mouse Bre1a/b (Rnf20/40)) acts as an important suppressor of chromosomal instability | Deficiency in mammalian histone H2B ubiquitin ligase Bre1 (Rnf20/Rnf40) leads to replication stress and chromosomal instability.
Chernikova SB, Razorenova OV, Higgins JP, Sishc BJ, Nicolau M, Dorth JA, Chernikova DA, Kwok S, Brooks JD, Bailey SM, Game JC, Brown JM., Free PMC Article | 06/2/2012 |
| our results suggest that RNF20 and RNF40, either via ubiquitylation of H2B or other targets, are coupled to the proliferation of prostate cancer cells. | Histone H2B ubiquitin ligases RNF20 and RNF40 in androgen signaling and prostate cancer cell growth.
Jääskeläinen T, Makkonen H, Visakorpi T, Kim J, Roeder RG, Palvimo JJ. | 05/19/2012 |
| RNF40 cooperates with SUPT16H to induce dynamic changes in chromatin structure during DNA double-strand break repair. | The H2B ubiquitin ligase RNF40 cooperates with SUPT16H to induce dynamic changes in chromatin structure during DNA double-strand break repair.
Kari V, Shchebet A, Neumann H, Johnsen SA. | 03/24/2012 |
| Studies indicate that H2B monoubiquitylation is driven primarily by an E3 ubiquitin ligase composed of the two RING finger proteins RNF20 and RNF40. | RNF20-RNF40: A ubiquitin-driven link between gene expression and the DNA damage response.
Shiloh Y, Shema E, Moyal L, Oren M. | 12/3/2011 |
| the observed defects in the radiation response of Bre1a/b-deficient cells | Deficiency in Bre1 impairs homologous recombination repair and cell cycle checkpoint response to radiation damage in mammalian cells.
Chernikova SB, Dorth JA, Razorenova OV, Game JC, Brown JM., Free PMC Article | 11/13/2010 |
| Formation of trimeric complex UbcH6 and RNF20/40 with PAF stimulates histone 2B monoubiquitination activity in vitro | Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation.
Zhu B, Zheng Y, Pham AD, Mandal SS, Erdjument-Bromage H, Tempst P, Reinberg D. | 01/21/2010 |
| Functional Analysis of the rat counterpart | Staring, a novel E3 ubiquitin-protein ligase that targets syntaxin 1 for degradation.
Chin LS, Vavalle JP, Li L. | 09/25/2003 |