| Association of poly(rC)-binding protein-2 with sideroflexin-3 through TOM20 as an iron entry pathway to mitochondria. | Association of poly(rC)-binding protein-2 with sideroflexin-3 through TOM20 as an iron entry pathway to mitochondria.
Mi D, Yanatori I, Zheng H, Kong Y, Hirayama T, Toyokuni S. | 06/5/2024 |
| AR antagonists develop drug resistance through TOMM20 autophagic degradation-promoted transformation to neuroendocrine prostate cancer. | AR antagonists develop drug resistance through TOMM20 autophagic degradation-promoted transformation to neuroendocrine prostate cancer.
Yin L, Ye Y, Zou L, Lin J, Dai Y, Fu Y, Liu Y, Peng Y, Gao Y, Fu Y, Qi X, Deng T, Zhang S, Li X., Free PMC Article | 08/16/2023 |
| Iron induces B cell pyroptosis through Tom20-Bax-caspase-gasdermin E signaling to promote inflammation post-spinal cord injury. | Iron induces B cell pyroptosis through Tom20-Bax-caspase-gasdermin E signaling to promote inflammation post-spinal cord injury.
Wu C, Wang L, Chen S, Shi L, Liu M, Tu P, Sun J, Zhao R, Zhang Y, Wang J, Pan Y, Ma Y, Guo Y., Free PMC Article | 07/25/2023 |
| TOMM20 as a Potential Prognostic Biomarker in Chordoma: Results From a High-Volume, Single-Center Study. | TOMM20 as a Potential Prognostic Biomarker in Chordoma: Results From a High-Volume, Single-Center Study.
Micaily I, Lee S, Basu Mallick A, Zhan T, O'Neill R, Gargano S, Hozack B, Thapa S, Martinez-Outschoorn U, Abraham J, Jiang W. | 05/11/2023 |
| Melatonin promoted osteogenesis of human periodontal ligament cells by regulating mitochondrial functions through the translocase of the outer mitochondrial membrane 20. | Melatonin promoted osteogenesis of human periodontal ligament cells by regulating mitochondrial functions through the translocase of the outer mitochondrial membrane 20.
Sun H, Zheng M, Liu J, Fan W, He H, Huang F. | 01/21/2023 |
| ATP13A2 modifies mitochondrial localization of overexpressed TOM20 to autolysosomal pathway. | ATP13A2 modifies mitochondrial localization of overexpressed TOM20 to autolysosomal pathway.
Hatori Y, Kanda Y, Nonaka S, Nakanishi H, Kitazawa T., Free PMC Article | 12/17/2022 |
| Structural basis of Tom20 and Tom22 cytosolic domains as the human TOM complex receptors. | Structural basis of Tom20 and Tom22 cytosolic domains as the human TOM complex receptors.
Su J, Liu D, Yang F, Zuo MQ, Li C, Dong MQ, Sun S, Sui SF., Free PMC Article | 07/2/2022 |
| Analysis of mitochondrial regulatory transcripts in publicly available datasets with validation in placentae from pre-term, post-term and fetal growth restriction pregnancies. | Analysis of mitochondrial regulatory transcripts in publicly available datasets with validation in placentae from pre-term, post-term and fetal growth restriction pregnancies.
Bartho LA, O'Callaghan JL, Fisher JJ, Cuffe JSM, Kaitu'u-Lino TJ, Hannan NJ, Clifton VL, Perkins AV. | 02/26/2022 |
| The receptor subunit Tom20 is dynamically associated with the TOM complex in mitochondria of human cells. | The receptor subunit Tom20 is dynamically associated with the TOM complex in mitochondria of human cells.
Bhagawati M, Arroum T, Webeling N, Montoro AG, Mootz HD, Busch KB., Free PMC Article | 02/12/2022 |
| TOM20-mediated transfer of Bcl2 from ER to MAM and mitochondria upon induction of apoptosis. | TOM20-mediated transfer of Bcl2 from ER to MAM and mitochondria upon induction of apoptosis.
Lalier L, Mignard V, Joalland MP, Lanoé D, Cartron PF, Manon S, Vallette FM., Free PMC Article | 09/25/2021 |
| Translocase of the outer mitochondrial membrane complex subunit 20 (TOMM20) facilitates cancer aggressiveness and therapeutic resistance in chondrosarcoma. | Translocase of the outer mitochondrial membrane complex subunit 20 (TOMM20) facilitates cancer aggressiveness and therapeutic resistance in chondrosarcoma.
Roche ME, Lin Z, Whitaker-Menezes D, Zhan T, Szuhai K, Bovee JVMG, Abraham JA, Jiang W, Martinez-Outschoorn U, Basu-Mallick A., Free PMC Article | 01/23/2021 |
| TOM70, but not TOM20, clusters in distinct OMM foci, frequently overlapping with sites in which the endoplasmic reticulum (ER) contacts mitochondria. Functionally, TOM70 depletion specifically impairs inositol trisphosphates (IP3)-linked ER to mitochondria Ca(2+) transfer. This phenomenon is dependent on the capacity of TOM70 to interact with IP3-receptors and favor their functional recruitment close to mitochondria. | TOM70 Sustains Cell Bioenergetics by Promoting IP3R3-Mediated ER to Mitochondria Ca(2+) Transfer.
Filadi R, Leal NS, Schreiner B, Rossi A, Dentoni G, Pinho CM, Wiehager B, Cieri D, Calì T, Pizzo P, Ankarcrona M. | 07/6/2019 |
| TOMM20, MCT1, and MCT4 expression was significantly different in Hodgkin and Reed Sternberg (HRS) cells. HRS have high expression of TOMM20, while tumor associated macrophages have absent TOMM20 expression. Tumor-infiltrating lymphocytes have low TOMM20 expression. Reactive lymph nodes in contrast to cHL tumors had low TOMM20, MCT1, and MCT4 expression in lymphocytes and macrophages. | Hodgkin lymphoma: A complex metabolic ecosystem with glycolytic reprogramming of the tumor microenvironment.
Mikkilineni L, Whitaker-Menezes D, Domingo-Vidal M, Sprandio J, Avena P, Cotzia P, Dulau-Florea A, Gong J, Uppal G, Zhan T, Leiby B, Lin Z, Pro B, Sotgia F, Lisanti MP, Martinez-Outschoorn U., Free PMC Article | 12/30/2017 |
| TOMM20 and MCT1 were highly expressed in diffuse large B-cell lymphoma lymphocytes, indicating an OXPHOS phenotype, whereas non-neoplastic lymphocytes in the control samples did not express these markers. | Mitochondrial and glycolytic metabolic compartmentalization in diffuse large B-cell lymphoma.
Gooptu M, Whitaker-Menezes D, Sprandio J, Domingo-Vidal M, Lin Z, Uppal G, Gong J, Fratamico R, Leiby B, Dulau-Florea A, Caro J, Martinez-Outschoorn U., Free PMC Article | 12/30/2017 |
| Gsk3beta and Tomm20 are substrates of the SCFFbxo7/PARK15 ubiquitin ligase associated with Parkinson's disease | Gsk3β and Tomm20 are substrates of the SCFFbxo7/PARK15 ubiquitin ligase associated with Parkinson's disease.
Teixeira FR, Randle SJ, Patel SP, Mevissen TE, Zenkeviciute G, Koide T, Komander D, Laman H., Free PMC Article | 06/24/2017 |
| TOMM20 protein is highly expressed in both anaplastic thyroid cancer and papillary thyroid cancer compared to non-cancerous thyroid tissue. | Mitochondrial Metabolism as a Treatment Target in Anaplastic Thyroid Cancer.
Johnson JM, Lai SY, Cotzia P, Cognetti D, Luginbuhl A, Pribitkin EA, Zhan T, Mollaee M, Domingo-Vidal M, Chen Y, Campling B, Bar-Ad V, Birbe R, Tuluc M, Martinez Outschoorn U, Curry J., Free PMC Article | 04/30/2016 |
| Tom20 was ubiquitously distributed in the organ of Corti, allowing well-delineated visualization of inner and outer hair cells. In the inner ear of aged subjects with Meniere's disease, there was decreased expression of Tom20. | Immunocytochemical localization of the translocase of the outer mitochondrial membrane (Tom20) in the human cochlea.
Balaker AE, Ishiyama P, Lopez IA, Ishiyama G, Ishiyama A. | 07/13/2013 |
| a novel model in which Tom20 binds Tom70 to facilitate preprotein release from the chaperones by competition | Interaction between the human mitochondrial import receptors Tom20 and Tom70 in vitro suggests a chaperone displacement mechanism.
Fan AC, Kozlov G, Hoegl A, Marcellus RC, Wong MJ, Gehring K, Young JC., Free PMC Article | 11/26/2011 |
| Observational study of gene-disease association. (HuGE Navigator) | Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ., Free PMC Article | 12/5/2010 |
| Tom34 unlike Tom20 does not interact with the leader sequences of mitochondrial precursor proteins | Tom34 unlike Tom20 does not interact with the leader sequences of mitochondrial precursor proteins.
Mukhopadhyay A, Avramova LV, Weiner H. | 01/21/2010 |
| the cytosolic domains of Tom20 and Tom22 function to maintain their substrate preproteins unfolded and prevent them from aggregating on the mitochondrial surface | Mitochondrial import receptors Tom20 and Tom22 have chaperone-like activity.
Yano M, Terada K, Mori M. | 01/21/2010 |