| Diagnostic Value of GSTP1, RASSF1, AND RASSF2 Methylation in Serum of Prostate Cancer Patients. | Diagnostic Value of GSTP1, RASSF1, AND RASSF2 Methylation in Serum of Prostate Cancer Patients.
Aykanli E, Arisan S, Arisan ED, Yavuzsan AH. | 05/23/2024 |
| Hyperhomocysteinemia may aggravate abdominal aortic aneurysm formation by up-regulating RASSF2. | Hyperhomocysteinemia may aggravate abdominal aortic aneurysm formation by up-regulating RASSF2.
Liu Z, Feng G, Chen Y, Fan J, Liang Z, Bi J, Dai X. | 02/9/2024 |
| RASSF effectors couple diverse RAS subfamily GTPases to the Hippo pathway. | RASSF effectors couple diverse RAS subfamily GTPases to the Hippo pathway.
Dhanaraman T, Singh S, Killoran RC, Singh A, Xu X, Shifman JM, Smith MJ. | 10/30/2021 |
| The RUNX1-ETO target gene RASSF2 suppresses t(8;21) AML development and regulates Rac GTPase signaling. | The RUNX1-ETO target gene RASSF2 suppresses t(8;21) AML development and regulates Rac GTPase signaling.
Stoner SA, Liu KTH, Andrews ET, Liu M, Arimoto KI, Yan M, Davis AG, Weng S, Dow M, Xian S, DeKelver RC, Carter H, Zhang DE., Free PMC Article | 10/31/2020 |
| suggest that circRASSF2 is a central component linking circRNAs to progression of LSCC via an miR-302b-3p/IGF-1R axis | CircRASSF2 promotes laryngeal squamous cell carcinoma progression by regulating the miR-302b-3p/IGF-1R axis.
Tian L, Cao J, Jiao H, Zhang J, Ren X, Liu X, Liu M, Sun Y. | 02/29/2020 |
| RASSF2 methylation was significantly higher in gastric cancer than in noncancerous tissues; RASSF2 gene methylation was not associated with gender and was not associated with lymph node metastasis. | Association Between RASSF2 Methylation and Gastric Cancer: A PRISMA-Compliant Systematic Review and Meta-Analysis.
Zhou K, Cai C, He Y, Zhou C, Zhao S, Ding X, Duan S. | 10/19/2019 |
| Results showed that in the endometrial adenocarcinoma (OEA group) and ovarian clear cell carcinoma (OCC group) groups, the methylation degrees of the RASSF2A promoter were obviously higher than that of the other two groups. The expression level of RASSF2A mRNA in the OEA and OCC groups was lower than that of the other two groups. | Relationship between methylation status of RASSF2A gene promoter and endometriosis-associated ovarian cancer.
Xia Y, Xiong N, Huang Y. | 04/21/2018 |
| we confirmed that the RASSF2-PAR-4 axis was mainly responsible for miR-7 functions in CAFs using bioinformatics methods. Overexpression of miR-7 in CAFs led to down-regulation of RASSF2, which dramatically decreased the secretion of PAR-4 from CAFs and then enhanced the proliferation and migration of the co-cultured cancer cells. | Cancer-associated fibroblasts promote cancer cell growth through a miR-7-RASSF2-PAR-4 axis in the tumor microenvironment.
Shen Z, Qin X, Yan M, Li R, Chen G, Zhang J, Chen W., Free PMC Article | 03/10/2018 |
| Results suggest that down-regulation of RASSF2, and RASSF6 is a tumor-specific phenomenon and their inactivation through CpG island methylation may play important roles in gastric cardia carcinogenesis. | Decreased expression and frequent promoter hypermethylation of RASSF2 and RASSF6 correlate with malignant progression and poor prognosis of gastric cardia adenocarcinoma.
Guo W, Dong Z, Guo Y, Shen S, Guo X, Kuang G, Yang Z. | 05/20/2017 |
| The statistically most significant association rs4813720 correlates with RASSF2 expression and may play a significant role in childhood ALL etiology. | A childhood acute lymphoblastic leukemia genome-wide association study identifies novel sex-specific risk variants.
Singh SK, Lupo PJ, Scheurer ME, Saxena A, Kennedy AE, Ibrahimou B, Barbieri MA, Mills KI, McCauley JL, Okcu MF, Dorak MT., Free PMC Article | 02/18/2017 |
| RASSF2 may be an important molecular marker for carcinogenesis, prognosis and progression in gastric cancer | Prognostic importance of RASSF2 expression in patients with gastric cancer who had undergone radical gastrectomy.
Aydin D, Bilici A, Kayahan S, Yavuzer D, Basar M, Aliustaoglu M. | 02/4/2017 |
| RASSF2 gene is differently methylated in luminal and non-luminal tumors and is a promising suppressor gene with clinical involvement in breast cancer | Differential involvement of RASSF2 hypermethylation in breast cancer subtypes and their prognosis.
Perez-Janices N, Blanco-Luquin I, Torrea N, Liechtenstein T, Escors D, Cordoba A, Vicente-Garcia F, Jauregui I, De La Cruz S, Illarramendi JJ, Coca V, Berdasco M, Kochan G, Ibañez B, Lera JM, Guerrero-Setas D., Free PMC Article | 08/13/2016 |
| our results suggest that RASSF2 may function as a tumor suppressor gene | Aberrant hypermethylation of RASSF2 in tumors and peripheral blood DNA as a biomarker for malignant progression and poor prognosis of esophageal squamous cell carcinoma.
Guo W, Dong Z, Cui J, Guo Y, Shen S, Guo X, Kuang G. | 07/30/2016 |
| We conclude that EPB41L3, RASSF2 and TSP-1 genes are involved in the pathogenesis of diffuse gliomas | EPB41L3, TSP-1 and RASSF2 as new clinically relevant prognostic biomarkers in diffuse gliomas.
Perez-Janices N, Blanco-Luquin I, Tuñón MT, Barba-Ramos E, Ibáñez B, Zazpe-Cenoz I, Martinez-Aguillo M, Hernandez B, Martínez-Lopez E, Fernández AF, Mercado MR, Cabada T, Escors D, Megias D, Guerrero-Setas D., Free PMC Article | 01/23/2016 |
| Promoter hypermethylation of RASSF2A is observed in cervical cancer, while not in normal cervical tissues. | Aberrant promoter methylation and silencing of RASSF2A gene in cervical cancer.
Zhang X, Ma Y, Wu Y, Lin L, Ma X, Zhang Y. | 05/23/2015 |
| Epigenetic inactivation of RASSF2A through aberrant promoter methylation may play an important role in the pathogenesis of epithelial ovarian cancer. | Aberrant methylation of RASSF2A in tumors and plasma of patients with epithelial ovarian cancer.
Wu Y, Zhang X, Lin L, Ma XP, Ma YC, Liu PS. | 11/22/2014 |
| results suggest that both RASSF1A and RASSF2 are novel epigenetically inactivated tumor suppressor genes in Ewing sarcoma and RASSF2 methylation may have prognostic implications for ES patients | RASSF2 methylation is a strong prognostic marker in younger age patients with Ewing sarcoma.
Gharanei S, Brini AT, Vaiyapuri S, Alholle A, Dallol A, Arrigoni E, Kishida T, Hiruma T, Avigad S, Grimer R, Maher ER, Latif F., Free PMC Article | 07/12/2014 |
| our results suggest that RASSF2 potentially functions as a new tumor-suppressor gene that is inactivated through hypermethylation in cervical cancer | RASSF2 hypermethylation is present and related to shorter survival in squamous cervical cancer.
Guerrero-Setas D, Pérez-Janices N, Blanco-Fernandez L, Ojer A, Cambra K, Berdasco M, Esteller M, Maria-Ruiz S, Torrea N, Guarch R. | 03/15/2014 |
| Promoter hypermethylation of RASSF2A is observed in pancreatic ductal adenocarcinoma, while not in normal pancreatic tissue. | Aberrant methylation of RASSF2A in human pancreatic ductal adenocarcinoma and its relation to clinicopathologic features.
Zhao L, Cui Q, Lu Z, Chen J. | 06/16/2012 |
| Hypermethylation of RASSF2 gene is associated with advanced gastric cancer. | Aberrant gene methylation is a biomarker for the detection of cancer cells in peritoneal wash samples from advanced gastric cancer patients.
Hiraki M, Kitajima Y, Koga Y, Tanaka T, Nakamura J, Hashiguchi K, Noshiro H, Miyazaki K. | 01/7/2012 |
| Sp1-mediated RASSF2A gene transcription is activated by p300 through histone acetylation, and this activation plays an important role in inducing late apoptosis. | Activation of RASSF2A by p300 induces late apoptosis through histone hyperacetylation.
Liu C, Pan Y, Wang X, Lu J, Huang B, Li X. | 02/26/2011 |
| Results suggest that RASSF2 encodes a novel epigenetically inactivated candidate tumor suppressor gene in thyroid carcinogenesis. | Frequent epigenetic inactivation of RASSF2 in thyroid cancer and functional consequences.
Schagdarsurengin U, Richter AM, Hornung J, Lange C, Steinmann K, Dammann RH., Free PMC Article | 01/22/2011 |
| Aberrant methylation of the RASSF2A gene with the subsequent loss of RASSF2A expression plays an important role in the pathogenesis of hepatocellular carcinoma. | RASSF2A promoter methylation in hepatitis B virus-related hepatocellular carcinogenesis and its correlation with elevated serum alpha-fetoprotein level.
Ren J, He W, Zhang R, Li Z, Cao W, Yao J, Zhu F, Zhang T, Wu G. | 10/23/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Data show that RASSF2 forms a direct and endogenous complex with prostate apoptosis response protein 4 (PAR-4) and that this interaction is regulated by K-Ras and is essential for the full apoptotic effects of PAR-4. | The Ras effector RASSF2 controls the PAR-4 tumor suppressor.
Donninger H, Hesson L, Vos M, Beebe K, Gordon L, Sidransky D, Liu JW, Schlegel T, Payne S, Hartmann A, Latif F, Clark GJ., Free PMC Article | 06/14/2010 |