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    PCLAF PCNA clamp associated factor [ Homo sapiens (human) ]

    Gene ID: 9768, updated on 3-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Knockdown of LINC01138 protects human chondrocytes against IL-1beta-induced damage by regulating the hsa-miR-1207-5p/KIAA0101 axis.

    Knockdown of LINC01138 protects human chondrocytes against IL-1β-induced damage by regulating the hsa-miR-1207-5p/KIAA0101 axis.
    Zhang J, Lv G., Free PMC Article

    02/4/2023
    KIAA0101 and IL2RA Were Identified as Core Genes in Hormone-Resistant Nephropathy.

    KIAA0101 and IL2RA Were Identified as Core Genes in Hormone-Resistant Nephropathy.
    Chen Y, Qian S, Chen Y, Liu K, Yin W, Luo X., Free PMC Article

    10/8/2022
    KIAA0101 in Malignant Pleural Mesothelioma: A Potential Diagnostic and Prognostic Marker.

    KIAA0101 in Malignant Pleural Mesothelioma: A Potential Diagnostic and Prognostic Marker.
    Lin P, Zhao Y, Li X, Liang Z.

    08/27/2022
    PCLAF promotes neuroblastoma G1/S cell cycle progression via the E2F1/PTTG1 axis.

    PCLAF promotes neuroblastoma G1/S cell cycle progression via the E2F1/PTTG1 axis.
    Liu X, Cai Y, Cheng C, Gu Y, Hu X, Chen K, Wu Y, Wu Z., Free PMC Article

    07/9/2022
    Circ_0005231 promotes the progression of esophageal squamous cell carcinoma via sponging miR-383-5p and regulating KIAA0101.

    Circ_0005231 promotes the progression of esophageal squamous cell carcinoma via sponging miR-383-5p and regulating KIAA0101.
    Sun Z, Zhang S, Zhang N, Wang J, Wang J, Liu J., Free PMC Article

    06/25/2022
    KIAA0101 knockdown inhibits glioma progression and glycolysis by inactivating the PI3K/AKT/mTOR pathway.

    KIAA0101 knockdown inhibits glioma progression and glycolysis by inactivating the PI3K/AKT/mTOR pathway.
    Wang K, Li J, Zhou B.

    04/16/2022
    PAF enhances cancer stem cell properties via beta-catenin signaling in hepatocellular carcinoma.

    PAF enhances cancer stem cell properties via β-catenin signaling in hepatocellular carcinoma.
    Li M, Mu XD, Song JR, Zhai PT, Cheng Y, Le Y, Li ZB., Free PMC Article

    02/19/2022
    Circular RNA TADA2A promotes proliferation and migration via modulating of miR638/KIAA0101 signal in nonsmall cell lung cancer.

    Circular RNA TADA2A promotes proliferation and migration via modulating of miR‑638/KIAA0101 signal in non‑small cell lung cancer.
    Zhang Y, Yao H, Li Y, Yang L, Zhang L, Chen J, Wang Y, Li X., Free PMC Article

    12/25/2021
    KIAA0101 as a new diagnostic and prognostic marker, and its correlation with gene regulatory networks and immune infiltrates in lung adenocarcinoma.

    KIAA0101 as a new diagnostic and prognostic marker, and its correlation with gene regulatory networks and immune infiltrates in lung adenocarcinoma.
    Hu S, Zeng W, Zhang W, Xu J, Yu D, Peng J, Wei Y., Free PMC Article

    07/24/2021
    MicroRNA216a5p suppresses esophageal squamous cell carcinoma progression by targeting KIAA0101.

    MicroRNA‑216a‑5p suppresses esophageal squamous cell carcinoma progression by targeting KIAA0101.
    Sun T, An Q, Yan R, Li K, Zhu K, Dang C, Yuan D., Free PMC Article

    07/24/2021
    PCNA-associated factor (KIAA0101/PCLAF) overexpression and gene copy number alterations in hepatocellular carcinoma tissues.

    PCNA-associated factor (KIAA0101/PCLAF) overexpression and gene copy number alterations in hepatocellular carcinoma tissues.
    Tantiwetrueangdet A, Panvichian R, Sornmayura P, Leelaudomlipi S, Macoska JA., Free PMC Article

    05/8/2021
    PAF remodels the DREAM complex to bypass cell quiescence and promote lung tumorigenesis.

    PAF remodels the DREAM complex to bypass cell quiescence and promote lung tumorigenesis.
    Kim MJ, Cervantes C, Jung YS, Zhang X, Zhang J, Lee SH, Jun S, Litovchick L, Wang W, Chen J, Fang B, Park JI, Kim MJ, Cervantes C, Jung YS, Zhang X, Zhang J, Lee SH, Jun S, Litovchick L, Wang W, Chen J, Fang B, Park JI., Free PMC Articles: PMC8052288, PMC8052288

    05/1/2021
    Synergistic effect of PAF inhibition and X-ray irradiation in non-small cell lung cancer cells.

    Synergistic effect of PAF inhibition and X-ray irradiation in non-small cell lung cancer cells.
    Chen Y, Jin Y, Ying H, Zhang P, Chen M, Hu X.

    05/1/2021
    PAF binds to the RBBP4 and inhibits the formation of the DREAM complex, which induces cell quiescence exit and cell proliferation.

    PAF remodels the DREAM complex to bypass cell quiescence and promote lung tumorigenesis.
    Kim MJ, Cervantes C, Jung YS, Zhang X, Zhang J, Lee SH, Jun S, Litovchick L, Wang W, Chen J, Fang B, Park JI, Kim MJ, Cervantes C, Jung YS, Zhang X, Zhang J, Lee SH, Jun S, Litovchick L, Wang W, Chen J, Fang B, Park JI., Free PMC Articles: PMC8052288, PMC8052288

    04/30/2021
    PAF-transactivated MYC induces stem and progenitor cell activation for intestinal tissue regeneration and tumorigenesis.

    PAF-Myc-Controlled Cell Stemness Is Required for Intestinal Regeneration and Tumorigenesis.
    Kim MJ, Xia B, Suh HN, Lee SH, Jun S, Lien EM, Zhang J, Chen K, Park JI., Free PMC Article

    04/30/2021
    PAF induced Wnt/beta-catenin signaling-mediated cell plasticity to maintain cancer cell stemness.

    PAF-Wnt signaling-induced cell plasticity is required for maintenance of breast cancer cell stemness.
    Wang X, Jung YS, Jun S, Lee S, Wang W, Schneider A, Sun Oh Y, Lin SH, Park BJ, Chen J, Keyomarsi K, Park JI., Free PMC Article

    04/30/2021
    PAF hyperactivates Wnt signaling by recruiting EZH2 to the beta-catenin transcriptional complex in a PCNA-independent manner, which promotes intestinal tumorigenesis.

    PAF and EZH2 induce Wnt/β-catenin signaling hyperactivation.
    Jung HY, Jun S, Lee M, Kim HC, Wang X, Ji H, McCrea PD, Park JI., Free PMC Article

    04/30/2021
    PAF activates MAPK signaling via LAMTOR3 upregulation.

    PAF-mediated MAPK signaling hyperactivation via LAMTOR3 induces pancreatic tumorigenesis.
    Jun S, Lee S, Kim HC, Ng C, Schneider AM, Ji H, Ying H, Wang H, DePinho RA, Park JI., Free PMC Article

    04/30/2021
    KIAA0101 and UbcH10 interact to regulate non-small cell lung cancer cell proliferation by disrupting the function of the spindle assembly checkpoint.

    KIAA0101 and UbcH10 interact to regulate non-small cell lung cancer cell proliferation by disrupting the function of the spindle assembly checkpoint.
    Lei H, Wang K, Jiang T, Lu J, Dong X, Wang F, Li Q, Zhao L., Free PMC Article

    04/24/2021
    Prognostic value and underlying mechanism of KIAA0101 in hepatocellular carcinoma: database mining and co-expression analysis.

    Prognostic value and underlying mechanism of KIAA0101 in hepatocellular carcinoma: database mining and co-expression analysis.
    Xu W, Wang X, Wu X, Yu S, Xiong J, Sang X, Zheng Y, Zhang Z., Free PMC Article

    04/24/2021
    Dysregulated NF-kappaB signal promotes the hub gene PCLAF expression to facilitate nasopharyngeal carcinoma proliferation and metastasis.

    Dysregulated NF-κB signal promotes the hub gene PCLAF expression to facilitate nasopharyngeal carcinoma proliferation and metastasis.
    Ma F, Zhi C, Wang M, Li T, Khan SA, Ma Z, Jing Z, Bo C, Zhou Q, Xia S, Huang S, Huang S, Zhang Z, Jia H, Cui X, Yao M, Ji T.

    12/26/2020
    IL-6 could induce autophagy by expressing NS5ATP9, while NS5ATP9 upregulated IL-6 levels in turn, which further induced autophagy.

    Role of IL-6-mediated expression of NS5ATP9 in autophagy of liver cancer cells.
    Lu H, Han M, Yuan X, Tursun K, Zhang Y, Li Y, Li Z, Feng S, Zhou L, Pan Z, Wang Q, Han K, Liu S, Cheng J.

    10/5/2019
    our biochemical data show that p15PAF impairs primer synthesis by pol eta-PCNA holoenzyme against both damaged and normal DNA templates. In light of our findings, we discuss the possible mechanistic roles of p15PAF in DNA replication and suppression of DNA lesion bypass.

    p15PAF binding to PCNA modulates the DNA sliding surface.
    De March M, Barrera-Vilarmau S, Crespan E, Mentegari E, Merino N, Gonzalez-Magaña A, Romano-Moreno M, Maga G, Crehuet R, Onesti S, Blanco FJ, De Biasio A., Free PMC Article

    06/29/2019
    MiR-30a-5p frequently downregulated in prostate cancer inhibits cell proliferation via targeting PCLAF

    MiR-30a-5p frequently downregulated in prostate cancer inhibits cell proliferation via targeting PCLAF.
    Zhao H, Lai X, Zhang W, Zhu H, Zhang S, Wu W, Wang S, Tang M, Deng Z, Tan J.

    05/11/2019
    Data demonstrated that NDRG1 is critical for mediating LANA to recruit PCNA onto terminal repeat (TR) of KSHV genome, and facilitates viral DNA replication and episome persistence. Findings suggest that NDRG1 plays an important role in KSHV viral genome replication, and provide new clues for understanding of KSHV persistence.

    NDRG1 facilitates the replication and persistence of Kaposi's sarcoma-associated herpesvirus by interacting with the DNA polymerase clamp PCNA.
    Zhang F, Liang D, Lin X, Zou Z, Sun R, Wang X, Liang X, Kaye KM, Lan K., Free PMC Article

    04/13/2019
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