| BOD1L mediates chromatin binding and non-canonical function of H3K4 methyltransferase SETD1A. | BOD1L mediates chromatin binding and non-canonical function of H3K4 methyltransferase SETD1A.
Hoshii T, Kikuchi S, Kujirai T, Masuda T, Ito T, Yasuda S, Matsumoto M, Rahmutulla B, Fukuyo M, Murata T, Kurumizaka H, Kaneda A., Free PMC Article | 09/9/2024 |
| SETD1A variant-associated psychosis: A systematic review of the clinical literature and description of two new cases. | SETD1A variant-associated psychosis: A systematic review of the clinical literature and description of two new cases.
Colijn MA, Carrion P, Poirier-Morency G, Rogic S, Torres I, Menon M, Lisonek M, Cook C, DeGraaf A, Thammaiah SP, Neelakant H, Willaeys V, Leonova O, White RF, Yip S, Mungall AJ, MacLeod PM, Gibson WT, Sullivan PF, Honer WG, Pavlidis P, Stowe RM. | 12/27/2023 |
| In Vivo and In Vitro Characterization of the RNA Binding Capacity of SETD1A (KMT2F). | In Vivo and In Vitro Characterization of the RNA Binding Capacity of SETD1A (KMT2F).
Amin HM, Szabo B, Abukhairan R, Zeke A, Kardos J, Schad E, Tantos A., Free PMC Article | 11/28/2023 |
| Epigenotype-genotype-phenotype correlations in SETD1A and SETD2 chromatin disorders. | Epigenotype-genotype-phenotype correlations in SETD1A and SETD2 chromatin disorders.
Lee S, Menzies L, Hay E, Ochoa E, Docquier F, Rodger F, Deshpande C, Foulds NC, Jacquemont S, Jizi K, Kiep H, Kraus A, Löhner K, Morrison PJ, Popp B, Richardson R, van Haeringen A, Martin E, Toribio A, Li F, Jones WD, Sansbury FH, Maher ER., Free PMC Article | 11/13/2023 |
| SETD1A function in leukemia is mediated through interaction with mitotic regulators BuGZ/BUB3. | SETD1A function in leukemia is mediated through interaction with mitotic regulators BuGZ/BUB3.
Perlee S, Kikuchi S, Nakadai T, Masuda T, Ohtsuki S, Matsumoto M, Rahmutulla B, Fukuyo M, Cifani P, Kentsis A, Roeder RG, Kaneda A, Hoshii T., Free PMC Article | 10/11/2023 |
| SETD1A drives stemness by reprogramming the epigenetic landscape in hepatocellular carcinoma stem cells. | SETD1A drives stemness by reprogramming the epigenetic landscape in hepatocellular carcinoma stem cells.
Chen J, Xu Z, Huang H, Tang Y, Shan H, Xiao F., Free PMC Article | 09/26/2023 |
| Molecular insight into the SETD1A/B N-terminal region and its interaction with WDR82. | Molecular insight into the SETD1A/B N-terminal region and its interaction with WDR82.
Bao S, Xu C. | 04/21/2023 |
| SETD1A regulates transcriptional pause release of heme biosynthesis genes in leukemia. | SETD1A regulates transcriptional pause release of heme biosynthesis genes in leukemia.
Hoshii T, Perlee S, Kikuchi S, Rahmutulla B, Fukuyo M, Masuda T, Ohtsuki S, Soga T, Nabet B, Kaneda A., Free PMC Article | 01/7/2023 |
| Loss-of-function variants in the schizophrenia risk gene SETD1A alter neuronal network activity in human neurons through the cAMP/PKA pathway. | Loss-of-function variants in the schizophrenia risk gene SETD1A alter neuronal network activity in human neurons through the cAMP/PKA pathway.
Wang S, Rhijn JV, Akkouh I, Kogo N, Maas N, Bleeck A, Ortiz IS, Lewerissa E, Wu KM, Schoenmaker C, Djurovic S, van Bokhoven H, Kleefstra T, Nadif Kasri N, Schubert D., Free PMC Article | 05/14/2022 |
| Novel missense SETD1A variants in Japanese patients with schizophrenia: Resequencing and association analysis. | Novel missense SETD1A variants in Japanese patients with schizophrenia: Resequencing and association analysis.
Morikawa R, Watanabe Y, Igeta H, Arta RK, Ikeda M, Okazaki S, Hoya S, Saito T, Otsuka I, Egawa J, Tanifuji T, Iwata N, Someya T. | 05/14/2022 |
| Cell type-specific mechanism of Setd1a heterozygosity in schizophrenia pathogenesis. | Cell type-specific mechanism of Setd1a heterozygosity in schizophrenia pathogenesis.
Chen R, Liu Y, Djekidel MN, Chen W, Bhattacherjee A, Chen Z, Scolnick E, Zhang Y., Free PMC Article | 04/23/2022 |
| Elevated placental histone H3K4 methylation via upregulated histone methyltransferases SETD1A and SMYD3 in preeclampsia and its possible involvement in hypoxia-induced pathophysiological process. | Elevated placental histone H3K4 methylation via upregulated histone methyltransferases SETD1A and SMYD3 in preeclampsia and its possible involvement in hypoxia-induced pathophysiological process.
Matsui H, Iriyama T, Sayama S, Inaoka N, Suzuki K, Yoshikawa M, Ichinose M, Sone K, Kumasawa K, Nagamatsu T, Fujisawa T, Naguro I, Ichijo H, Fujii T, Osuga Y. | 03/5/2022 |
| Histone methyltransferase SETD1A participates in lung cancer progression. | Histone methyltransferase SETD1A participates in lung cancer progression.
Du M, Gong P, Zhang Y, Liu Y, Liu X, Zhang F, Wang X., Free PMC Article | 12/18/2021 |
| Characterization of SETD1A haploinsufficiency in humans and Drosophila defines a novel neurodevelopmental syndrome. | Characterization of SETD1A haploinsufficiency in humans and Drosophila defines a novel neurodevelopmental syndrome.
Kummeling J, Stremmelaar DE, Raun N, Reijnders MRF, Willemsen MH, Ruiterkamp-Versteeg M, Schepens M, Man CCO, Gilissen C, Cho MT, McWalter K, Sinnema M, Wheless JW, Simon MEH, Genetti CA, Casey AM, Terhal PA, van der Smagt JJ, van Gassen KLI, Joset P, Bahr A, Steindl K, Rauch A, Keller E, Raas-Rothschild A, Koolen DA, Agrawal PB, Hoffman TL, Powell-Hamilton NN, Thiffault I, Engleman K, Zhou D, Bodamer O, Hoefele J, Riedhammer KM, Schwaibold EMC, Tasic V, Schubert D, Top D, Pfundt R, Higgs MR, Kramer JM, Kleefstra T. | 10/16/2021 |
| The H3K4 methyltransferase SETD1A is required for proliferation of non-small cell lung cancer cells by promoting S-phase progression. | The H3K4 methyltransferase SETD1A is required for proliferation of non-small cell lung cancer cells by promoting S-phase progression.
Kang JY, Park JW, Hwang Y, Hahm JY, Park J, Park KS, Seo SB. | 09/18/2021 |
| MLL5, a histone modifying enzyme, regulates androgen receptor activity in prostate cancer cells by recruiting co-regulators, HCF1 and SET1. | MLL5, a histone modifying enzyme, regulates androgen receptor activity in prostate cancer cells by recruiting co-regulators, HCF1 and SET1.
Lee KH, Kim BC, Jeong CW, Ku JH, Kim HH, Kwak C., Free PMC Article | 08/28/2021 |
| Histone methyltransferase SETD1A interacts with HIF1alpha to enhance glycolysis and promote cancer progression in gastric cancer. | Histone methyltransferase SETD1A interacts with HIF1α to enhance glycolysis and promote cancer progression in gastric cancer.
Wu J, Chai H, Xu X, Yu J, Gu Y., Free PMC Article | 07/3/2021 |
| Mechanism for DPY30 and ASH2L intrinsically disordered regions to modulate the MLL/SET1 activity on chromatin. | Mechanism for DPY30 and ASH2L intrinsically disordered regions to modulate the MLL/SET1 activity on chromatin.
Lee YT, Ayoub A, Park SH, Sha L, Xu J, Mao F, Zheng W, Zhang Y, Cho US, Dou Y., Free PMC Article | 06/5/2021 |
| LncRNA CANT1 suppresses retinoblastoma progression by repellinghistone methyltransferase in PI3Kgamma promoter. | LncRNA CANT1 suppresses retinoblastoma progression by repellinghistone methyltransferase in PI3Kγ promoter.
Ni H, Chai P, Yu J, Xing Y, Wang S, Fan J, Ge S, Wang Y, Jia R, Fan X., Free PMC Article | 03/27/2021 |
| SETD1A augments sorafenib primary resistance via activating YAP in hepatocellular carcinoma. | SETD1A augments sorafenib primary resistance via activating YAP in hepatocellular carcinoma.
Wu J, Chai H, Li F, Ren Q, Gu Y. | 11/21/2020 |
| Results found that SETD1A is highly regulated in the poor outcome triple negative breast cancer (TNBC) cell line and may epigenetically regulate miR205 in TNBCs. | Dysregulation of non-histone molecule miR205 and LRG1 post-transcriptional de-regulation by SETD1A in triple negative breast cancer.
Mohamad Hanif EA. | 04/25/2020 |
| SETD1A, but not RBBP5 or ASH2L, was found to interact with the DNA damage repair protein RAD18. | SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.
Alsulami M, Munawar N, Dillon E, Oliviero G, Wynne K, Alsolami M, Moss C, Ó Gaora P, O'Meara F, Cotter D, Cagney G., Free PMC Article | 01/18/2020 |
| H3K4me3 levels positively correlate with WHO grade malignancy in pediatric EPNs and are associated with progression free survival in patients with posterior fossa group A EPNs (PF-EPN-A). Reduction of H3K4me3 by silencing its methyltransferase SETD1A, in primary cultured EPN cells increased cell response to chemotherapy | Global Reduction of H3K4me3 Improves Chemotherapeutic Efficacy for Pediatric Ependymomas.
Lewis R, Li YD, Hoffman L, Hashizume R, Gravohac G, Rice G, Wadhwani NR, Jie C, Pundy T, Mania-Farnell B, Mayanil CS, Soares MB, Lei T, James CD, Foreman NK, Tomita T, Xi G., Free PMC Article | 11/30/2019 |
| SETD1A is essential to maintain mitosis and proliferation and its suppression unleashes the tumor suppressive effects of senescence. | SETD1A protects from senescence through regulation of the mitotic gene expression program.
Tajima K, Matsuda S, Yae T, Drapkin BJ, Morris R, Boukhali M, Niederhoffer K, Comaills V, Dubash T, Nieman L, Guo H, Magnus NKC, Dyson N, Shioda T, Haas W, Haber DA, Maheswaran S., Free PMC Article | 08/24/2019 |
| SET1A-mediated mono-methylation at K342 is an essential regulatory mechanism for regulating YAP activity and tumorigenesis. | SET1A-Mediated Mono-Methylation at K342 Regulates YAP Activation by Blocking Its Nuclear Export and Promotes Tumorigenesis.
Fang L, Teng H, Wang Y, Liao G, Weng L, Li Y, Wang X, Jin J, Jiao C, Chen L, Peng X, Chen J, Yang Y, Fang H, Han D, Li C, Jin X, Zhang S, Liu Z, Liu M, Wei Q, Liao L, Ge X, Zhao B, Zhou D, Qin HL, Zhou J, Wang P. | 04/13/2019 |