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    CD74 CD74 molecule [ Homo sapiens (human) ]

    Gene ID: 972, updated on 2-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Potential protumor function of CD74 in clear cell renal cell carcinoma.

    Potential protumor function of CD74 in clear cell renal cell carcinoma.
    Ezaki A, Yano H, Pan C, Fujiwara Y, Anami T, Ibe Y, Motoshima T, Yatsuda J, Esumi S, Miura Y, Kamba T, Komohara Y.

    08/23/2024
    Macrophage migration inhibitory factor mediates skin aging via CD74: Insights from single-cell and bulk RNA sequencing data.

    Macrophage migration inhibitory factor mediates skin aging via CD74: Insights from single-cell and bulk RNA sequencing data.
    Wu S, Ouyang Y, Hu Y, Jiang L, Fu C, Lei L, Zhang Y, Guo H, Huang J, Chen J, Zeng Q.

    08/22/2024
    CD74 supports accumulation and function of regulatory T cells in tumors.

    CD74 supports accumulation and function of regulatory T cells in tumors.
    Bonnin E, Rodrigo Riestra M, Marziali F, Mena Osuna R, Denizeau J, Maurin M, Saez JJ, Jouve M, Bonté PE, Richer W, Nevo F, Lemoine S, Girard N, Lefevre M, Borcoman E, Vincent-Salomon A, Baulande S, Moreau HD, Sedlik C, Hivroz C, Lennon-Duménil AM, Tosello Boari J, Piaggio E., Free PMC Article

    05/23/2024
    CD74-ROS1 L2026M mutant enhances autophagy through the MEK/ERK pathway to promote invasion, metastasis and crizotinib resistance in non-small cell lung cancer cells.

    CD74-ROS1 L2026M mutant enhances autophagy through the MEK/ERK pathway to promote invasion, metastasis and crizotinib resistance in non-small cell lung cancer cells.
    Xu X, Li Y, Xu R, Meng Y, Li Z, Zuo D, Wu Y.

    03/15/2024
    Increased Expression of CD74 in Atherosclerosis Associated with Inflammatory Responses of Endothelial Cells and Macrophages.

    Increased Expression of CD74 in Atherosclerosis Associated with Inflammatory Responses of Endothelial Cells and Macrophages.
    Ke K, Wu Z, Lin J, Lin L, Huang N, Yang W.

    03/4/2024
    CD74 is associated with inflamed tumor immune microenvironment and predicts responsiveness to PD-1/CTLA-4 bispecific antibody in patients with solid tumors.

    CD74 is associated with inflamed tumor immune microenvironment and predicts responsiveness to PD-1/CTLA-4 bispecific antibody in patients with solid tumors.
    Wang J, Li X, Xiao G, Desai J, Frentzas S, Wang ZM, Xia Y, Li B., Free PMC Article

    02/4/2024
    Macrophage migration inhibitory factor receptor CD74 expression is associated with expansion and differentiation of effector T cells in COVID-19 patients.

    Macrophage migration inhibitory factor receptor CD74 expression is associated with expansion and differentiation of effector T cells in COVID-19 patients.
    Westmeier J, Brochtrup A, Paniskaki K, Karakoese Z, Werner T, Sutter K, Dolff S, Limmer A, Mittermüller D, Liu J, Zheng X, Koval T, Kaidashev I, Berger MM, Herbstreit F, Brenner T, Witzke O, Trilling M, Lu M, Yang D, Babel N, Westhoff T, Dittmer U, Zelinskyy G., Free PMC Article

    11/14/2023
    CD74 deficiency reduces trophoblast invasion and proliferation mediated by SIRT1 in preeclampsia.

    CD74 deficiency reduces trophoblast invasion and proliferation mediated by SIRT1 in preeclampsia.
    Liu Z, Pei J, Zhang X, Wang C, Tang Y, Liu H, Yu Y, Luo S, Gu W.

    11/7/2023
    CD74 Promotes a Pro-Inflammatory Tumor Microenvironment by Inducing S100A8 and S100A9 Secretion in Pancreatic Cancer.

    CD74 Promotes a Pro-Inflammatory Tumor Microenvironment by Inducing S100A8 and S100A9 Secretion in Pancreatic Cancer.
    Hong WC, Lee DE, Kang HW, Kim MJ, Kim M, Kim JH, Fang S, Kim HJ, Park JS., Free PMC Article

    08/31/2023
    The invariant chain CD74 protein is a cell surface binding partner of TIMP-1 in breast cancer cells.

    The invariant chain CD74 protein is a cell surface binding partner of TIMP-1 in breast cancer cells.
    Høeberg M, Noer JB, Vistesen MV, Bartels A, Bech EM, Nygård SB, Lademann U, Stenvang J, Liu S, Fuglsang AT, Brünner N, Moreira JMA., Free PMC Article

    08/4/2023
    Tumor Necrosis Factor alpha-Dependent Lung Inflammation Promotes the Progression of Lung Adenocarcinoma Originating From Alveolar Type II Cells by Upregulating MIF-CD74.

    Tumor Necrosis Factor α-Dependent Lung Inflammation Promotes the Progression of Lung Adenocarcinoma Originating From Alveolar Type II Cells by Upregulating MIF-CD74.
    Cao L, Wang X, Liu X, Meng W, Guo W, Duan C, Liang X, Kang L, Lv P, Lin Q, Zhang R, Zhang X, Shen H.

    03/22/2023
    Decreased expression of surfactant Protein-C and CD74 in alveolar epithelial cells during influenza virus A(H1N1)pdm09 and H3N2 infection.

    Decreased expression of surfactant Protein-C and CD74 in alveolar epithelial cells during influenza virus A(H1N1)pdm09 and H3N2 infection.
    Ibañez LI, Martinez VP, Iglesias AA, Bellomo CM, Alonso DO, Coelho RM, Martinez Peralta L, Periolo N.

    03/3/2023
    Macrophage Migration Inhibitory Factor (MIF) Promotes Increased Proportions of the Highly Permissive Th17-like Cell Profile during HIV Infection.

    Macrophage Migration Inhibitory Factor (MIF) Promotes Increased Proportions of the Highly Permissive Th17-like Cell Profile during HIV Infection.
    Trifone C, Baquero L, Czernikier A, Benencio P, Leng L, Laufer N, Quiroga MF, Bucala R, Ghiglione Y, Turk G., Free PMC Article

    11/12/2022
    CXCR4 and CD74 together enhance cell survival in response to macrophage migration-inhibitory factor in chronic lymphocytic leukemia.

    CXCR4 and CD74 together enhance cell survival in response to macrophage migration-inhibitory factor in chronic lymphocytic leukemia.
    Thavayogarajah T, Sinitski D, El Bounkari O, Torres-Garcia L, Lewinsky H, Harjung A, Chen HR, Panse J, Vankann L, Shachar I, Bernhagen J, Koschmieder S.

    11/12/2022
    Roles of LINC01473 and CD74 in osteoblasts in multiple myeloma bone disease.

    Roles of LINC01473 and CD74 in osteoblasts in multiple myeloma bone disease.
    Peng F, Yan S, Liu H, Liu Z, Jiang F, Cao P, Fu R., Free PMC Article

    07/2/2022
    Interplay between soluble CD74 and macrophage-migration inhibitory factor drives tumor growth and influences patient survival in melanoma.

    Interplay between soluble CD74 and macrophage-migration inhibitory factor drives tumor growth and influences patient survival in melanoma.
    Fukuda Y, Bustos MA, Cho SN, Roszik J, Ryu S, Lopez VM, Burks JK, Lee JE, Grimm EA, Hoon DSB, Ekmekcioglu S., Free PMC Article

    04/16/2022
    Absence of CD74 Isoform at 41kDa Prevents the Heterotypic Associations between CD74 and CD44 in Human Lung Adenocarcinoma-derived Cells.

    Absence of CD74 Isoform at 41kDa Prevents the Heterotypic Associations between CD74 and CD44 in Human Lung Adenocarcinoma-derived Cells.
    Al Abdulmonem W, Rasheed Z, Aljohani ASM, Omran OM, Rasheed N, Alkhamiss A, A M Al Salloom A, Alhumaydhi F, Alblihed MA, Al Ssadh H, Khan MI, Fernández N.

    01/22/2022
    Identification of invariant chain CD74 as a functional receptor of tissue inhibitor of metalloproteinases-1 (TIMP-1).

    Identification of invariant chain CD74 as a functional receptor of tissue inhibitor of metalloproteinases-1 (TIMP-1).
    Schoeps B, Eckfeld C, Flüter L, Keppler S, Mishra R, Knolle P, Bayerl F, Böttcher J, Hermann CD, Häußler D, Krüger A., Free PMC Article

    11/22/2021
    CD74 promotes perineural invasion of cancer cells and mediates neuroplasticity via the AKT/EGR-1/GDNF axis in pancreatic ductal adenocarcinoma.

    CD74 promotes perineural invasion of cancer cells and mediates neuroplasticity via the AKT/EGR-1/GDNF axis in pancreatic ductal adenocarcinoma.
    Zhang JF, Tao LY, Yang MW, Xu DP, Jiang SH, Fu XL, Liu DJ, Huo YM, Liu W, Yang JY, Hua R, Lu P, Sun YW.

    10/30/2021
    PIVKA-II: A biomarker for diagnosing and monitoring patients with pancreatic adenocarcinoma.

    PIVKA-II: A biomarker for diagnosing and monitoring patients with pancreatic adenocarcinoma.
    Tartaglione S, Mancini P, Viggiani V, Chirletti P, Angeloni A, Anastasi E., Free PMC Article

    10/23/2021
    Bacterial lipopolysaccharide induces the intracellular expression of trophoblastic specific CD74 isoform in human first trimester trophoblast cells: Correlation with unsuccessful early pregnancy.

    Bacterial lipopolysaccharide induces the intracellular expression of trophoblastic specific CD74 isoform in human first trimester trophoblast cells: Correlation with unsuccessful early pregnancy.
    Al Abdulmonem W, Rasheed Z, Al Ssadh H, Alkhamiss A, Aljohani AS, Fernández N.

    09/25/2021
    CD74 and CD44 Expression on CTCs in Cancer Patients with Brain Metastasis.

    CD74 and CD44 Expression on CTCs in Cancer Patients with Brain Metastasis.
    Loreth D, Schuette M, Zinke J, Mohme M, Piffko A, Schneegans S, Stadler J, Janning M, Loges S, Joosse SA, Lamszus K, Westphal M, Müller V, Glatzel M, Matschke J, Gebhardt C, Schneider SW, Belczacka I, Volkmer B, Greinert R, Yaspo ML, Harter PN, Pantel K, Wikman H., Free PMC Article

    07/31/2021
    CD74 Signaling Links Inflammation to Intestinal Epithelial Cell Regeneration and Promotes Mucosal Healing.

    CD74 Signaling Links Inflammation to Intestinal Epithelial Cell Regeneration and Promotes Mucosal Healing.
    Farr L, Ghosh S, Jiang N, Watanabe K, Parlak M, Bucala R, Moonah S., Free PMC Article

    05/15/2021
    Association of variant on the promoter of cluster of differentiation 74 in graves disease and graves ophthalmopathy.

    Association of variant on the promoter of cluster of differentiation 74 in graves disease and graves ophthalmopathy.
    Liu YH, Shen CY, Tsai FJ., Free PMC Article

    04/3/2021
    Expression and clinical significance of CD74 and MMP-9 in colon adenocarcinomas.

    Expression and clinical significance of CD74 and MMP-9 in colon adenocarcinomas.
    Ruan P, Gu Y, Zhou H, Zhang W, Wang D, Liang J, Li C.

    02/13/2021
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