| Inhibition of ULK1/2 and KRAS[G12C] controls tumor growth in preclinical models of lung cancer. | Inhibition of ULK1/2 and KRAS(G12C) controls tumor growth in preclinical models of lung cancer.
Ghazi PC, O'Toole KT, Srinivas Boggaram S, Scherzer MT, Silvis MR, Zhang Y, Bogdan M, Smith BD, Lozano G, Flynn DL, Snyder EL, Kinsey CG, McMahon M., Free PMC Article | 09/4/2024 |
| ULK2 Is a Key Pro-Autophagy Protein That Contributes to the High Chemoresistance and Disease Relapse in FLT3-Mutated Acute Myeloid Leukemia. | ULK2 Is a Key Pro-Autophagy Protein That Contributes to the High Chemoresistance and Disease Relapse in FLT3-Mutated Acute Myeloid Leukemia.
Lai J, Yang C, Shang C, Chen W, Chu MP, Brandwein J, Lai R, Wang P., Free PMC Article | 02/6/2024 |
| An ULK1/2-PXN mechanotransduction pathway suppresses breast cancer cell migration. | An ULK1/2-PXN mechanotransduction pathway suppresses breast cancer cell migration.
Liang P, Zhang J, Wu Y, Zheng S, Xu Z, Yang S, Wang J, Ma S, Xiao L, Hu T, Jiang W, Huang C, Xing Q, Kundu M, Wang B., Free PMC Article | 11/7/2023 |
| CircARHGAP12 Triggers Mesenchymal Stromal Cell Autophagy to Facilitate its Effect on Repairing Diabetic Wounds by Sponging miR-301b-3p/ATG16L1 and miR-301b-3p/ULK2. | CircARHGAP12 Triggers Mesenchymal Stromal Cell Autophagy to Facilitate its Effect on Repairing Diabetic Wounds by Sponging miR-301b-3p/ATG16L1 and miR-301b-3p/ULK2.
Meng F, Shen F, Ling H, Jin P, Zhou D, Li Q. | 06/25/2022 |
| Methylation silencing of ULK2 via epithelial-mesenchymal transition causes transformation to poorly differentiated gastric cancers. | Methylation silencing of ULK2 via epithelial-mesenchymal transition causes transformation to poorly differentiated gastric cancers.
Motoo I, Nanjo S, Ando T, Yamashita S, Ushijima T, Yasuda I. | 03/12/2022 |
| Association between Unc-51-like autophagy activating kinase 2 gene polymorphisms and schizophrenia in the Korean population. | Association between Unc-51-like autophagy activating kinase 2 gene polymorphisms and schizophrenia in the Korean population.
Kang WS, Lee SM, Hwang D, Park HJ, Kim JW., Free PMC Article | 02/19/2022 |
| PKClambda/iota inhibition activates an ULK2-mediated interferon response to repress tumorigenesis. | PKCλ/ι inhibition activates an ULK2-mediated interferon response to repress tumorigenesis.
Linares JF, Zhang X, Martinez-Ordoñez A, Duran A, Kinoshita H, Kasashima H, Nakanishi N, Nakanishi Y, Carelli R, Cappelli L, Arias E, Yashiro M, Ohira M, Patel S, Inghirami G, Loda M, Cuervo AM, Diaz-Meco MT, Moscat J., Free PMC Article | 01/8/2022 |
| Long noncoding RNA growth arrestspecific 5 (GAS5) acts as a tumor suppressor by promoting autophagy in breast cancer. | Long non‑coding RNA growth arrest‑specific 5 (GAS5) acts as a tumor suppressor by promoting autophagy in breast cancer.
Li G, Qian L, Tang X, Chen Y, Zhao Z, Zhang C., Free PMC Article | 05/1/2021 |
| ULK complex organization in autophagy by a C-shaped FIP200 N-terminal domain dimer. | ULK complex organization in autophagy by a C-shaped FIP200 N-terminal domain dimer.
Shi X, Yokom AL, Wang C, Young LN, Youle RJ, Hurley JH., Free PMC Article | 03/20/2021 |
| Coxsackievirus infection induces a non-canonical autophagy independent of the ULK and PI3K complexes. | Coxsackievirus infection induces a non-canonical autophagy independent of the ULK and PI3K complexes.
Mohamud Y, Shi J, Tang H, Xiang P, Xue YC, Liu H, Ng CS, Luo H., Free PMC Article | 03/6/2021 |
| Copper is an essential regulator of the autophagic kinases ULK1/ULK2 to drive lung adenocarcinoma. | Copper is an essential regulator of the autophagic kinases ULK1/2 to drive lung adenocarcinoma.
Tsang T, Posimo JM, Gudiel AA, Cicchini M, Feldser DM, Brady DC., Free PMC Article | 04/25/2020 |
| The data presented here provide structural models and chemical starting points for the development of ULK1/2 dual inhibitors with improved selectivity for future exploitation of autophagy inhibition. | Conservation of structure, function and inhibitor binding in UNC-51-like kinase 1 and 2 (ULK1/2).
Chaikuad A, Koschade SE, Stolz A, Zivkovic K, Pohl C, Shaid S, Ren H, Lambert LJ, Cosford NDP, Brandts CH, Knapp S., Free PMC Article | 12/21/2019 |
| MiRNA-26b may play a key role in cell growth and death of laryngeal carcinoma through ULK2 and the PTEN/AKT pathway. | Downregulation of miRNA-26b inhibits cancer proliferation of laryngeal carcinoma through autophagy by targeting ULK2 and inactivation of the PTEN/AKT pathway.
Wang S, Guo D, Li C. | 04/28/2018 |
| The serine/threonine kinase ULK2 binds to and phosphorylates CARMA2sh. | CARMA2sh and ULK2 control pathogen-associated molecular patterns recognition in human keratinocytes: psoriasis-linked CARMA2sh mutants escape ULK2 censorship.
Scudiero I, Mazzone P, D'Andrea LE, Ferravante A, Zotti T, Telesio G, De Rubis G, Reale C, Pizzulo M, Muralitharan S, Vito P, Stilo R., Free PMC Article | 11/4/2017 |
| ULK1/2 function as a bifurcate-signaling node that sustains glucose metabolic fluxes besides initiation of autophagy in response to nutritional deprivation. | ULK1/2 Constitute a Bifurcate Node Controlling Glucose Metabolic Fluxes in Addition to Autophagy.
Li TY, Sun Y, Liang Y, Liu Q, Shi Y, Zhang CS, Zhang C, Song L, Zhang P, Zhang X, Li X, Chen T, Huang HY, He X, Wang Y, Wu YQ, Chen S, Jiang M, Chen C, Xie C, Yang JY, Lin Y, Zhao S, Ye Z, Lin SY, Chiu DT, Lin SC. | 08/5/2017 |
| Knockdown of ULK2 expression significantly induced autophagy, EMT, and cell migration in lung cancer cell line. | Uncoordinated 51-like kinase 2 signaling pathway regulates epithelial-mesenchymal transition in A549 lung cancer cells.
Kim YH, Baek SH, Kim EK, Ha JM, Jin SY, Lee HS, Ha HK, Song SH, Kim SJ, Shin HK, Yong J, Kim DH, Kim CD, Bae SS. | 05/6/2017 |
| miR-26b was down-regulated in LNCaP, DU145, C4-2 and PC-3 cells compared to the two normal prostate cells RWPE-1 and WPMY-1 except DU145 cells. This inversely correlates with ULK2 level in the same cell lines. | MiR-26b inhibits autophagy by targeting ULK2 in prostate cancer cells.
John Clotaire DZ, Zhang B, Wei N, Gao R, Zhao F, Wang Y, Lei M, Huang W. | 08/13/2016 |
| a novel signaling pathway identified whereby starvation-induced activation of ULK leads to phosphorylation of endogenous DENND3, with subsequent activation of Rab12 and initiation of membrane trafficking events required for autophagy | Phosphorylation of the exchange factor DENND3 by ULK in response to starvation activates Rab12 and induces autophagy.
Xu J, Fotouhi M, McPherson PS., Free PMC Article | 03/12/2016 |
| Kapbeta2 interacts with ULK2 through ULK2's putative PY-NLS motif, and facilitates transport from the cytoplasm to the nucleus, depending on its Ser1027 residue phosphorylation by PKA, thereby reducing autophagic activity. | ULK2 Ser 1027 Phosphorylation by PKA Regulates Its Nuclear Localization Occurring through Karyopherin Beta 2 Recognition of a PY-NLS Motif.
Shin SH, Lee EJ, Chun J, Hyun S, Kang SS., Free PMC Article | 03/5/2016 |
| Glioblastoma and glioma cell lines had low levels of ULK2 transcripts. ULK2 promoter methylation and transcript levels showed significant negative correlation. | Methylation silencing of ULK2, an autophagy gene, is essential for astrocyte transformation and tumor growth.
Shukla S, Patric IR, Patil V, Shwetha SD, Hegde AS, Chandramouli BA, Arivazhagan A, Santosh V, Somasundaram K., Free PMC Article | 02/21/2015 |
| First identification and naming of ULK2 as an ortholog of mouse ULK2. | The protein kinase complement of the human genome.
Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S. | 12/2/2013 |
| In response to DNA damage, ULK1 and ULK2 are upregulated by p53. The upregulation of ULK1 (ULK2)/ATG13 complex by p53 is necessary for the sustained autophagy activity induced by DNA damage. | Upregulation of human autophagy-initiation kinase ULK1 by tumor suppressor p53 contributes to DNA-damage-induced cell death.
Gao W, Shen Z, Shang L, Wang X., Free PMC Article | 04/21/2012 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| The ULK-Atg13-FIP200 complexes are direct targets of mTOR and important regulators of autophagy in response to mTOR signaling. | ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery.
Jung CH, Jun CB, Ro SH, Kim YM, Otto NM, Cao J, Kundu M, Kim DH., Free PMC Article | 01/21/2010 |