| RAPGEF2 mediates oligomeric Abeta-induced synaptic loss and cognitive dysfunction in the 3xTg-AD mouse model of Alzheimer's disease. | RAPGEF2 mediates oligomeric Aβ-induced synaptic loss and cognitive dysfunction in the 3xTg-AD mouse model of Alzheimer's disease.
Jang YN, Jang H, Kim GH, Noh JE, Chang KA, Lee KJ., Free PMC Article | 02/5/2022 |
| Disruption of MAGI2-RapGEF2-Rap1 signaling contributes to podocyte dysfunction in congenital nephrotic syndrome caused by mutations in MAGI2. | Disruption of MAGI2-RapGEF2-Rap1 signaling contributes to podocyte dysfunction in congenital nephrotic syndrome caused by mutations in MAGI2.
Zhu B, Cao A, Li J, Young J, Wong J, Ashraf S, Bierzynska A, Menon MC, Hou S, Sawyers C, Campbell KN, Saleem MA, He JC, Hildebrandt F, D'Agati VD, Peng W, Kaufman L., Free PMC Article | 10/24/2020 |
| Cdk5-mediated phosphorylation of RapGEF2 controls neuronal migration in the developing cerebral cortex. | Cdk5-mediated phosphorylation of RapGEF2 controls neuronal migration in the developing cerebral cortex.
Ye T, Ip JP, Fu AK, Ip NY., Free PMC Article | 11/14/2015 |
| local accumulation of PDZGEF at the apical membrane during establishment of epithelial polarity is mediated by electrostatic interactions between positively charged side chains in the PDZ domain and negatively charged phosphatidic acid. | The PDZ domain of the guanine nucleotide exchange factor PDZGEF directs binding to phosphatidic acid during brush border formation.
Consonni SV, Brouwer PM, van Slobbe ES, Bos JL., Free PMC Article | 06/20/2015 |
| SCF(FBXW11) bound, polyubiquitylated, and destabilized RAPGEF2, a guanine nucleotide exchange factor that activates the small GTPase RAP1 | Substrate trapping proteomics reveals targets of the βTrCP2/FBXW11 ubiquitin ligase.
Kim TY, Siesser PF, Rossman KL, Goldfarb D, Mackinnon K, Yan F, Yi X, MacCoss MJ, Moon RT, Der CJ, Major MB., Free PMC Article | 02/14/2015 |
| JAM-A regulates epithelial permeability via association with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and control contraction of the apical cytoskeleton. | JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA., Free PMC Article | 09/27/2014 |
| NEDD4-1 regulates cell migration and invasion through ubiquitination of CNrasGEF in vitro. | NEDD4-1 regulates migration and invasion of glioma cells through CNrasGEF ubiquitination in vitro.
Zhang H, Nie W, Zhang X, Zhang G, Li Z, Wu H, Shi Q, Chen Y, Ding Z, Zhou X, Yu R., Free PMC Article | 09/20/2014 |
| We report that in response to factors that promote cell motility, the Rap guanine exchange factor RAPGEF2 is rapidly phosphorylated by I-kappa-B-kinase-beta and casein kinase-1alpha and consequently degraded by the proteasome. | Control of epithelial cell migration and invasion by the IKKβ- and CK1α-mediated degradation of RAPGEF2.
Magliozzi R, Low TY, Weijts BG, Cheng T, Spanjaard E, Mohammed S, van Veen A, Ovaa H, de Rooij J, Zwartkruis FJ, Bos JL, de Bruin A, Heck AJ, Guardavaccaro D. | 02/15/2014 |
| Data indicate that expression of Rapgef2 in embryonic kidney 293T cells enables cAMP-Rap1-ERK signaling. | Rapgef2 connects GPCR-mediated cAMP signals to ERK activation in neuronal and endocrine cells.
Emery AC, Eiden MV, Mustafa T, Eiden LE., Free PMC Article | 01/25/2014 |
| DNA methylation shows genome-wide association of NFIX, RAPGEF2 and MSRB3 with gestational age at birth. | DNA methylation shows genome-wide association of NFIX, RAPGEF2 and MSRB3 with gestational age at birth.
Lee H, Jaffe AE, Feinberg JI, Tryggvadottir R, Brown S, Montano C, Aryee MJ, Irizarry RA, Herbstman J, Witter FR, Goldman LR, Feinberg AP, Fallin MD., Free PMC Article | 07/14/2012 |
| PDZ-GEF activates Rap1 under resting conditions to stabilize cell-cell junctions and maintain basal integrity | Epac1 and PDZ-GEF cooperate in Rap1 mediated endothelial junction control.
Pannekoek WJ, van Dijk JJ, Chan OY, Huveneers S, Linnemann JR, Spanjaard E, Brouwer PM, van der Meer AJ, Zwartkruis FJ, Rehmann H, de Rooij J, Bos JL. | 01/14/2012 |
| Data show that the interaction of PDZ-GEF1 with an internalized neurotrophin receptor transported to late endosomes induces sustained activation of both Rap1 and ERK and neurite outgrowth. | Rap1-PDZ-GEF1 interacts with a neurotrophin receptor at late endosomes, leading to sustained activation of Rap1 and ERK and neurite outgrowth.
Hisata S, Sakisaka T, Baba T, Yamada T, Aoki K, Matsuda M, Takai Y., Free PMC Article | 01/21/2010 |
| PSD-95/Dlg/ZO-1 homology (PDZ)-RhoGEF was isolated from mouse brain as a plexin-B1-specific interacting protein | The semaphorin receptor plexin-B1 signals through a direct interaction with the Rho-specific nucleotide exchange factor, LARG.
Aurandt J, Vikis HG, Gutkind JS, Ahn N, Guan KL., Free PMC Article | 01/21/2010 |
| Regulation of G protein-linked guanine nucleotide exchange factors for Rho, PDZ-RhoGEF, and LARG by tyrosine phosphorylation: evidence of a role for focal adhesion kinase | Regulation of G protein-linked guanine nucleotide exchange factors for Rho, PDZ-RhoGEF, and LARG by tyrosine phosphorylation: evidence of a role for focal adhesion kinase.
Chikumi H, Fukuhara S, Gutkind JS. | 01/21/2010 |